Happy to share our latest publication led by our PhD student James Johnston and Hyunsu Jeon at ND Chemical and Biomolecular Engineering in Biomaterials Science – recognized as an Emerging Investigator article! Small extracellular vesicles (sEVs) are emerging as nanocarriers in drug delivery, but scaling their production for clinical applications remains a challenge. In our new work, we tackle this problem with a novel 3D culture platform that significantly boosts sEV production. 💡 Key innovation: We developed a piezoelectric nanofibrous scaffold (PES), coupled with acoustic stimulation, to mimic a natural 3D microenvironment. This platform led to a 15.7-fold increase in sEV production per cell, with particle size and protein composition consistent with standard methods. 🔬 How it works: 3D cell culture + acoustic stimulation synergize to activate key pathways involved in sEV production. Cell morphology shifts in 3D lead to cytoskeleton redistribution and enhanced intracellular vesicle trafficking. Many thanks to our collaborators who contributed to this work, and to Biomaterials Science for recognizing us with the Emerging Investigator honor. Read more: https://lnkd.in/ghXcMr2v #DrugDelivery #Biomaterials #ExtracellularVesicles #3DCellCulture #EmergingInvestigator #ScientificInnovation #Biotech #BiomedicalScience
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Excited to learn that Hematene (2D Hematite) like non-van der Waals 2D Materials are getting more attention! 🔥 Our review article on non-van der Waals 2D materials, which was published in Materials Today, has been referenced in a recent perspective article published in Science Magazine 👇 https://lnkd.in/eAQbCEi4
Accelerating 2D materials discovery
science.org
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Excited to share some fantastic news! Our paper titled "Highly Ordered Nanoassemblies of Janus Spherocylindrical Nanoparticles Adhering to Lipid Vesicles" has been published in ACS Nano, one of the most prestigious journals in nanotechnology! As the first author, I am incredibly proud of this achievement and grateful for the hard work of our team. This research opens up exciting possibilities in the field, offering insights into highly ordered nanostructures, induced via self-assembly. Special thanks to my co-authors for their dedication and expertise. Looking forward to the impact this work will have on advancing nanotechnology. Read the full paper here: https://lnkd.in/eRHrhvm4 #Nanotechnology #AppliedPhysics #ACSNano
Highly Ordered Nanoassemblies of Janus Spherocylindrical Nanoparticles Adhering to Lipid Vesicles
pubs.acs.org
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It gives me immense joy to share the news of our recent publication: Selective Segregation of Thermo-Responsive Microgels via Microfluidic Technology. This paper is especially dear to me as it was one of my last projects during my PhD, which is now brought to fruition by my colleagues/dearest friends. I thank them deeply for their continued support and faith in this work. Shout out to Marek Bekir and Daniela Vasquez! The paper talks about an elegant solution of selectively segregating similar sized microgels of different charges using a combined effect of pressure-driven microfluidic flow and precise temperature control. Read more about how thermo-responsive mirogels undergo a volume phase transition change during heating, causing them to shrink and correspondingly changing their drift along a pressure driven shear flow, allowing for their selective control and segregation: https://lnkd.in/eSB6-qCi
Selective Segregation of Thermo‐Responsive Microgels via Microfluidic Technology
onlinelibrary.wiley.com
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Bio-Inspired Bonding: 🌊🦐 Researchers have unlocked the secret of chitosan, a natural polymer sourced from shellfish, to create hydrogels that embrace each other instantly and with unwavering tenacity. These sticky wonders hold promise for medical applications, tissue engineering, and beyond. 🌟💧 #BiomedicalBreakthroughs #NatureKnowsBest #BioMaterials #AdhesiveInnovation #NatureInspired #ScienceProgress #SmartMaterials #Bioengineering #linkedin #dailypost
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This excellent paper by Perez-Potti et. al. describes studies on in depth characterization of the biomolecular coronas of polymer coated inorganic nanoparticles with differential centrifugal sedimetation. Quoting from the abstract: "Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularly for small-sized functional nanoparticles of 5 nm diameter or smaller, where current particle sizing techniques struggle to provide the required sensitivity and accuracy. There is a clear need for the development of new reliable characterisation approaches for the physico-chemical characterisation of nanoparticles with significant accuracy, particularly for the analysis of the particles in the presence of complex biological fluids. Herein, we show that the Differential Centrifugal Sedimentation can be utilised as a high-precision tool for the reliable characterisation of functional nanoparticles of different materials. We report a method to correlate the sedimentation shift with the polymer and biomolecule adsorption on the nanoparticle surface, validating the developed core–shell model. We also highlight its limit when measuring nanoparticles of smaller size and the need to use several complementary methods when characterising nanoparticle corona complexes."
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#cbt #academicpublishing A quest for revisiting analysis of #polycaprolactone #crystallinity. Authors: Bronwin Dargaville and Dietmar W. Hutmacher. Published in Cell Press Trends in Chemistry. Read more: https://lnkd.in/gcWyyDPW This opinion proposes the need and benefits of revisiting both theory and methods to generate critical reference data for the quantification of polymer crystallinity, outlining a case study for polycaprolactone (PCL), the most widely used #biodegradable polymer in biomedical and environmental research and products. No recent studies have been published in this direction, with the trend over the past 20 years being toward advanced applications of polymers, to the detriment of fundamental study. This opinion addresses strategies for the re-evaluation of the standard melting enthalpy reference data for PCL. This enquiry is intended to challenge current acceptance of a long-held mindset and is expected to facilitate the generation of the most accurate and up-to-date information for use in the pursuit of answers to our generation’s most pressing scientific questions. More publications from our Centre: https://lnkd.in/gwVZR7eR #medicalmanufacturing #biomedical #medicalengineering #medicalinnovation #medicalresearch #medical #roboticsurgery #3dbioprinting #tissueengineering #biomechanics #collaboration #qut
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🔬 Unveiling Dopant Distribution in Conjugated Polymers! 🔬 BioPACIFIC MIP researchers are utilizing resonant soft X-ray scattering (P-RSoXS) to explore how dopants and counterions distribute within crystalline and amorphous domains of poly(3-hexylthiophene) (P3HT). Key findings: - Insights into dopant orientation and structural interactions. - A computational framework to simulate soft X-ray scattering. - A pathway to optimize charge transport in doped polymers. This research advances our understanding of semiconducting materials and their potential in electronic applications! 📖 Read the full paper: https://bit.ly/49EecHe Congrats Phong Nguyen, Devon Callan, Evan Plunkett, Max Gruschka Nima Alizadeh, Matthew Landsman, Gregory Su, Eliot Gann, Christopher Bates, Dean DeLongchamp, Michael Chabinyc #PolymerScience #MaterialsInnovation #BioPACIFICMIP #ConjugatedPolymers #Research
Resonant Soft X-ray Scattering Reveals the Distribution of Dopants in Semicrystalline Conjugated Polymers
pubs.acs.org
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🌟 Check out our latest publication: "Liquid Crystalline Collagen Assemblies as Substrates for Directed Alignment of human Schwann cells," co-authored with Luis Carlos Pinzon Herrera, Saja Alshafeay, Leonard A. Harris, Jorge Almodovar, and Karthik Nayani. Peripheral nerve injuries impact over 20 million people in the U.S., costing $150 billion annually. While nerve guidance conduits (NGCs) are promising, they face challenges in guiding cells across larger nerve gaps, limiting effectiveness in extensive repairs. Our research tackles this by using liquid crystalline (LC) collagen to create large-scale, aligned domains that mimic the native extracellular matrix. This platform allows for human Schwann cells alignment and growth, a breakthrough in nerve repair biomaterials. We developed centimeter-scale aligned scaffolds with directional cues at concentrations well below the LC forming concentration, opening new avenues for scalable, impactful NGCs. Thank you to my co-authors and everyone involved! 🔗 https://lnkd.in/gBptGfA4 #NerveRegeneration #Biomaterials #TissueEngineering #HealthcareInnovation
Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells
pubs.rsc.org
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Nano-imprinted polymeric nanoparticles immobilized on Miniaturized SPR sensor for virus detection. Miniaturization of SPR comes with several challenges, and largely dependent on user's experience and expertise. A detailed methodology is presented in this article to use portable SPR.
📣Highly-Cited Paper #Article #recommendation Synthesis of Molecularly Imprinted Polymer Nanoparticles for SARS-CoV-2 Virus Detection Using Surface Plasmon Resonance by Aabha Bajaj, Jakob Trimpert, Ibrahim Abdulhalim, and Zeynep Altintas. 👉https://lnkd.in/eNE_ANn6 MDPI, Technical University of Berlin, Ben-Gurion University of the Negev, Freie Universität Berlin, Kiel University #molecular #imprinting #polymer #surface #plasmon #resonance #pointofcare #virus #diagnostics #chemical #biosensors #sensing #chemosensors This article belongs to the Special Issue Advances in the Manufacture of Sensors Based on Molecularly Imprinted Polymers: https://lnkd.in/dStxXJt
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New publication from Cluster Members Chantal Barwig, Annabelle Sonn, ANKIT MISHRA, Eva Blasco, Christine Selhuber-Unkel, Alumnus Tobias S., as well as Sadaf Pashapour! 🙌 In this study, the scientist introduces a new method for equipping microfluidic chips with thermoresponsive hydrogels using two-photon polymerization direct laser writing, allowing the transformation of static microfluidic channels into reconfigurable dynamic microfluidic systems. Microfluidic tools aim to integrate several laboratory steps into a single device. They allow the study and manipulation of various chemical and biological processes, while using the unique behavior of fluids and flows at small scales. As a result, they are widely used in lab-on-chip devices, drug delivery systems, or miniaturized cell cultures. However, microfluidic devices often have limited flexibility and are typically designed for single functions. They lack the flexibility and real-time adaptability needed to manipulate fluids and molecules within the microfluidic framework. This new approach addresses some of these challenges and offers great flexibility and a high degree of freedom to fabricate dynamic microfluidic devices with great adaptability to experimental conditions in real time. 👉https://lnkd.in/e5sNYqSs #3DPrinting #Microfluidic #DLW #Hydrogels #publication
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Scientist
2moAmazing work 🙂 Vesicles tend to have lower encapsulation efficiency compared to Lnps, thus enhancing number of vesicles delivered is a welcome change 👍 insightful direction for the field 😊