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⚡Last chance to submit your abstract for the 16th edition of 'Transcription and chromatin'! ⚡ You have only a week left to work on it so you can join this must-attend meeting brining together leading experts in the field and covering all aspects of transcription 👌🏻💯 ✍🏻 Submit your abstract by 3 June! Topics: 🧬 General basal transcriptional machinery 🧬 Pol II function, pausing and the role of RNA in transcription 🧬 Chromatin modifications and transcription 🧬 Chromatin readers, writers and epigenetic regulation 🧬 Condensates, hubs and speckles 🧬 Transcription regulation during embryonic development and disease 🧬 Genome topology and three-dimensional regulation 🧬 Quantitative and theoretical approaches 🧬 Imaging of transcription and genome 📅 24 – 27 August 2024 📍 EMBL Heidelberg and Virtual ➡️ s.embl.org/trm24-01 #EMBLTranscript

The landmark Human Genome Project took 10 years of unprecedented collaboration and $3 billion in investment to complete. It has since contributed significantly to advances in medicine and genomics, improving our ability to understand our world and shape our future. Today, a single genomic lab can achieve the same feat (sequencing an entire human genome) in less than a day and for under CAD $1,000. This presents remarkable opportunities for innovation. But is Canada making the most of our advantages in this area? Learn more in a new op-ed about genomics research by Suzanne Gill, President and CEO of Genome British Columbia: https://lnkd.in/gC5UC2Nu

Nature Portfolio interviews Juozas Gordevicius, founder of VUGENE! “Lithuania has a large pool of scientific talent. Our clients include research laboratories looking at the origins, causes, treatments and diagnostics of various complex disorders, such as cancers or neurodegenerative diseases. At VUGENE, we manage large data sets, perform quality control, process raw data and do statistical analysis. It has always been my dream to do something that could be used in medical practice. Vugene is concentrating on early diagnostics. The company works a lot in the neurodegeneration field, mostly sequencing epigenomic data sets. Currently, 30 projects are running in parallel,” says Juozas Gordevičius. 👉 Learn more about how bioinformatics brought one scientist back home to Lithuania: https://lnkd.in/dYenhZ9i #VUGENE #bioinformatics #biotech #research #datascience 📷 Image credits: Asta Balciunaite Gordeviciene

Are you ready for the RNA revolution? Here's how Polaris Genomics is tapping into biology for mental health discovery. https://lnkd.in/enjUnMyn A must-read for scientific forward thinkers and health advocates from all walks, a recent NY Times article by Nobel laureate Dr. Thomas Cech discusses the growing importance of RNA in the field of biology.   This is particularly relevant for biotech companies like Polaris Genomics, leaders in this new and innovative field, creating novel platforms for research and diagnosis advancement centered on the untapped knowledge within our RNA. Dr. Cech highlights how RNA, once seen as a mere messenger molecule overshadowed by DNA, is now being recognized for its potential in fields including medicine and biotechnology. #Genomics #RNA #MentalHealth #MentalHealthResearch

At the core of the science behind Abivax is miR-124, a #microRNA that is well characterized in the scientific literature. miR-124 interacts with specific messenger RNA targets, decreasing their translation into their respective proteins. For more information about our science, visit https://lnkd.in/eKZnghcg.

#Grateful for the #opportunity to share what can happen when two distinct classes of #molecular #switches..........that were never thought to work together.....came together in a closed loop #circuit within our cells (link 👇). Upon finding that the circuit enables the highly evolved eukaryotic cells to #learn and #adapt in uncertain #environments (much like intelligent "agents" learn in #transformative #AI), we felt compelled to look further. Oh what fun it is to be able to continue to peel the proverbial onion with colleagues at UC San Diego Jacobs School of Engineering, UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and University of Michigan. Read more: https://lnkd.in/gms5EQCg #signal #transduction. #Consortium for #Cell-Inspired-Systems-Engineering (#ConCISE). UC San Diego Institute for Network Medicine (iNetMed), #Quantitative #Biology; #Biological #Intelligence; #MachineLearning; #ReinforcementLearning; Padmini Rangamani, Irina Kufareva; Geoffrey Chang; gary luker; Saptarshi Sinha; Mahitha Shree Anandachar; Celia Espinoza; Raktim Mukherjee.

🔎🧬 IRB Barcelona researchers led by Dr. Modesto Orozco develop an innovative computational model to precisely predict the position of nucleosomes in the genome👇 ✅ The approach combines Machine Learning techniques, signal transmission theory, and the physical properties of DNA. ✅ Published in NAR Nucleic Acids Research, this breakthrough opens up new opportunities to study the relationship between nucleosome architecture and gene expression regulation. Read more here ➡️ bit.ly/4dFeRsz 📌 DOI: 10.1093/nar/gkae689 Alba Sala Huerta Mireia Labrador PhD Diana Camila Buitrago Ospina Pau de Jorge Aranda Federica Battistini Isabelle Brun-Heath Modesto Orozco Universitat de Barcelona BioExcel CoE Ministerio de Ciencia, Innovación y Universidades ICERCA - Centres de Recerca de Catalunya Barcelona Institute of Science and Technology (BIST) Parc Científic de Barcelona #IRBScience #Bioinformatics #Research

Why does Alltrna need #machinelearning to unlock #tRNA biology? tRNAs are programmable molecules with a diverse biology of sequences and modifications that are key to their structure, function, and stability. There’s the potential for approximately 10^34 tRNA sequences and more than 120 natural and synthetic modifications for each nucleotide – yielding the opportunity to generate more engineered tRNA oligonucleotides than atoms in the universe What this diversity means is that there is a huge amount of flexibility in tRNA sequences without perturbing their function. Our ML-enabled platform empowers Alltrna to explore the possible sequence space to design therapeutic molecules optimized not only for biological activity, but also for tolerability, stability, manufacturability, and a host of other characteristics required in drug design. Our CEO Michelle Werner will explore this topic and more at the #RNALeaders conference in #SanDiego next month. Hear a preview of the talk here: https://lnkd.in/gPqgNu3R See the RNA Leaders conference agenda here – note new day/time for the talk: https://lnkd.in/g93QgSzv #RNA #tRNAmedicines #tRNAbiology #rarediseases #geneticmedicines #programmablemedicines #AI #machinelearning #StopCodonDisease

Exciting News! 🎉 2020 Chemistry Nobel Laureate Dr. Jennifer Doudna has revealed her top 3 book picks to understand the gene-editing revolution in The New Yorker. Among them is 'Editing Humanity', written by our very own Executive Editor of The CRISPR Journal, Kevin Davies. Check out the full article and learn why Kevin’s book is considered essential reading for understanding the promise and potential peril of CRISPR: https://hubs.li/Q02TRkcC0 #CRISPR #GeneEditing #KevinDavies #TheCRISPRJournal #Biotech #ScientificInnovation #JenniferDoudna

Salamanders Grow New Toes - https://lnkd.in/gihGfgmF Okazaki, Mar 22 (News On Japan) - Salamanders are well-known for their ability to completely regenerate lost limbs, but it has now been discovered that they can also regrow parts, such as toes, that they were not born with. https://lnkd.in/gFYgFR2V A research team led by Kenichi Suzuki, a special associate professor at the Institute for Basic Biology, investigated the regenerative capabilities of salamanders by amputating the hind legs of individuals that were genetically unable to form toes and other parts. The team continued their observations following the amputation. It was already known that salamanders can regenerate lost limbs and heal internal organs within a few months. The novelty here is that they managed to grow fully functional toes that were previously nonexistent. Suzuki believes that humans possess regenerative capabilities similar to those of salamanders. Unraveling this mechanism could not only speed up injury recovery but also pave the way for the use of artificial organs, thus holding promising applications for human medicine. Source: ANN Source