ABCs Of ADCs

Back-to-back episodes of the Business of Biotech found us talking ADCs with two biotech builders on opposite ends of the continuum last month. On episode 203, Mythic Therapeutics, Inc. CSO Brian Fiske , Ph.D. painted the picture of his company’s early efforts, focusing on Mythic’s buildout as it develops an ADC pipeline. The following week, Daiichi Sankyo , Inc. CEO Ken Keller offered the story of a mature and well-resourced company’s pivot into the space back when ADCs weren’t yet cool again – a pivot that helped incite the modality’s resurgence. Lots of valuable lessons from both perspectives – check those episodes out here.

I’m not getting off the ADC train anytime soon. I’ll host an ADC-development-focused Bioprocess Online Live digital event on July 9 featuring my friend Joe Daccache, Ph.D. , who knows more about the ADC market than anyone and thinks they’ll be more impactful than cell therapy, as well as Vincerx Pharma VP of Medical Affairs Amy Johnson , Ph.D. and Mythic Therapeutics, Inc. ’s own COO Sandra Poole . For those not familiar, Bioprocess Online Live is kinda like the Business of Biotech, but live, interactive, and a bit more technical. If you’re developing ADCs, or interested in developing them, or just curious about their impact, you ought to join us. You can register here.

In the meantime, here’s a roundup of some recent Business of Biotechy content from my colleagues at Life Science Connect that you probably shouldn’t miss.

By the way – I love feedback and respond to all of it. Tell me what you’re picking, what you’re panning, and what you’d like to hear on the Business of Biotech next. Thanks for listening!

Matthew Pillar , Business of Biotech host and chief editor, Bioprocess Online

Biotech Beat

Will QMM Hinder CDMO Capacity?

CDMO capacity continues to thwart biotech progress, as the biotech builders we talk with are still lamenting wait times of, in some cases, 12-24 months. Louis Garguilo over at Outsourced Pharma talked with Moderna regulatory pro Jason Kerr for this piece on the Quality Management Maturity movement, which could at once help sponsors assess CDMO reliability while exacerbating demand for select, well-ranking CDMOs. READ NOW →

More Than Cheesesteak

This column from Cell & Gene’s  Erin Harris reminded me of a recent Business of Biotech episode featuring Intellia Therapeutics, Inc. 's John Leonard , where we discussed the elements prerequisite to building a true biotech hub. Philly’s got ‘em in spades, and this interview with some of the folks responsible for its growth offers the goods on why Philadelphia isn’t just a great place for cheesesteak — it’s the cell & gene therapy city to watch. READ NOW →

Biotech Needs More Sportsmanship

Regeneron is spearheading a sportsmanlike effort to make progress in digital biomarkers, hallmarked by a recent conference on the topic that invited all comers — even competitive biopharma companies. Our own Dan Schell at Clinical Leader caught up with conference chair Rinol Alaj , who rationalized it this way: “we can compete on a drug, but not how to measure that mechanism.” Read about the Digital Biomarker Summit and why it pulled cutthroat competition into the same venue. READ NOW →

A CDMO For Your mRNA

How’s that headline for alphabet soup? My friend and colleague Anna Rose Welch , editorial and community director at Advancing RNA. and I will be collaborating on more RNA-focused episodes of the Business of Biotech (like this one with Orna Therapeutics Tom Barnes , Ph.D.). Anna Rose keeps her finger on the pulse of the burgeoning RNA space, as evidenced by this piece that offers advice on making mRNA-specific CDMO selections. READ NOW →

Quotes Of The Month

“I think, at a high level, your job as a very early stage entrepreneur who's just starting out is to take bad ideas seriously.”

― Brian Fiske , Ph.D., CSO, Mythic Therapeutics, Inc. , Episode 203

“All of a sudden I was not just the junior marketer with a sales background I became the guy that came up with this insight and, with that came a completely different level of confidence.”

― Ken Keller , President & CEO, Daiichi Sankyo , Episode 204

“You can’t succeed without talent… and you do need to have a solid scientific hypothesis to build upon. We're not going to launch a company unless we can find both.”

― Jonathan Behr , Ph.D., Partner, SV Health Investors' Dementia Discovery Fund (DDF) , Episode 205

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