Bacteria Breakthrough: Fusobacterium Shows Promise in Fighting Head and Neck Cancer

Researchers at Guy's and St Thomas' and King's College London have made a groundbreaking discovery in the ongoing fight against head and neck cancer. Their study, published in Cancer Communications, reveals that a common oral bacteria, Fusobacterium, may actually help destroy cancer cells and improve patient outcomes.

Contrary to its perceived role in promoting bowel cancer, Fusobacterium is believed to bring about a protective effect in head and neck squamous cell carcinoma (HNSCC). Consequently, patients with higher levels of this bacteria in their tumors have consistently shown better prognosis and survival rates. In laboratory tests, Fusobacterium was found to reduce the number of viable cancer cells by 70-99% in cell cultures.

This study, funded by Guy's Cancer Charity and Cancer Research UK, is indeed a significant step forward in understanding the intricate relationship between the microbiome and cancer. The study authors believe that the said bacteria have the potential to ‘melt head and neck cancer cells’ and are they are now focused on translating this knowledge into improved treatments for patients.

While further research is needed for a more conclusive validation, this discovery has opened up new possibilities for developing safe treatments with fewer side effects for head and neck cancer patients. Going forward, Fusobacterium could serve as a key biomarker to predict treatment efficacy and help guide personalized treatment strategies.

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