Cancer detection and diagnostics based on a Fluorescent GLUT5 probe.
Determining the presence of cancer, as well as its type and malignancy, is a stressful process for patients that can take up to two weeks to get a diagnosis. With a new bit of technology -- a sugar-transporting biosensor - researchers at Michigan Technological University hope to reduce that timeframe down to minutes.
A team of chemists and engineers from Michigan Tech lays the groundwork vision. In the Royal Society of Chemistry's journal Chemical Communications, the team explains the basic science behind multicolor probes that enable targeting of cancer-relevant fructose transporter, delving into the image-based detection of cancer cells. In the journal it explains Biosensors applications for breast cancer detection and differentiating nonmalignant, premalignant and malignant cancer cells.
The ManCou multi colored fluorescent probe glows different colors and different intensities depending on a cancer cell's type and malignancy.
Two Michigan Tech researchers- Marina Tanasova,assistant professor of chemistry, and Smitha Rao,assistant professor of biomedical engineering made a collaboration to build a tiny fluorescent probe that seeks out the fructose transporter named GLUT5.
Cells need carbohydrates; facilitative glucose transporters (GLUTs) bring nutrients in and out of cells. When metabolic swings kick is interested from cancer development, the overall makeup of GLUTs change so that more or less GLUT's are active. Fructose transporters like GLUT5 are of particular interest because of the direct connection between fructose uptake and cancer development, which also changes as cancer progresses and becomes malignant.
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