CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIAL INFECTION IN INTENSIVE CARE UNIT PATIENTS: ANTIBIOTIC RESISTANCE ANALYSIS & PREDICTIVE MODEL DEVELOPMENT

The excessive utilization of carbapenem antibiotics has resulted in a rise in infections caused by carbapenem-resistant gram-negative bacteria (CR-GNB), which poses a significant public health hazard. These infections are prevalent in intensive care units (ICUs) because of invasive procedures, low immunity, and severe illnesses. 

Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa are the most commonly responsible organisms for these infections. Treatment options are limited due to the strong resistance of these bacteria. Predictive models for CR-GNB infections in ICU patients have yielded inconsistent outcomes, making it crucial to identify risk factors and establish a reliable predictive model for personalized treatments. The study retrospectively examined data from ICU patients to establish a scientific basis for clinical treatment and preventive measures against CR-GNB infections. 

In summary, this study investigated antibiotic resistance in CR-GNB. A nomogram for predicting the risk of CR-GNB infection in ICU patients was developed and validated using independent factors. These findings could aid in personalized treatment and the implementation of effective control measures to reduce the risk of CR-GNB infection, especially in ICU settings.

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