"Eicosapentaenoic Acid Induces Anti-inflammatory transcriptomic landscape in T cells implicating a Pathway Independent of Triglyceride Lowering in ..
John Nelson MD,FACC,FNLA,FASNC
Director at California Cardiovascular Institute
Tremendous article by Nathalie A. Reilly et al.Performed RNA and ATAC-sequencing on non-activated CD4+T cells exposed to EPA,OA(Oleic Acid),PA(Palmitic Acid) or control after 48 hours.Non activated CD4+T cells were obtained from buffy coats of anonymous blood bank donors
"We find that EPA-exposed CD4+T cells downregulate immune response related genes such as HLA-DRA,CD69, and IL2RA while upregulating genes involved in oxidative stress prevention ,such as NQO1"
NQO1 (NAD(P)quinone oxidoreductase-1)is an important anti-oxidant and is regulated transcriptionally by Nrf2 and was shown to be upregulated in an elegant study by Samuel C.R.Sherratt etal(JAHA.2024,13:e034076)
It is important to remember that the immune response plays an important role in the development of atherosclerosis and as pointed out in this study that the " majority of immune cells in atherosclerotic plaque are T cells of which 1/2 are CD4+."
A tremendous amount of wonderful new information expanding our knowledge of EPA's transcriptomic effects on immune cells in this study and my hat is off to all the authors.
The pleiotropic landscape of EPA's myriad of non-lipid effects continues to increase at an amazing rate from when Dr.Viet Le and I published our Guest Editorial in Lipid Spin in 2017 "Eicosapentaenoic Acid:Pleiotropic Extraordinaire? "
Director of Preventive Cardiology at HCNT and CEO Iatros Synergy Corp
3wJohn, thank you for sharing this study. From a preventive cardiology perspective, the findings reinforce EPA’s role in modulating inflammation and oxidative stress, key drivers of atherosclerosis. The downregulation of immune-related genes and upregulation of Nrf2-regulated antioxidant pathways like NQO1 align with the cardiovascular benefits seen in studies like REDUCE-IT highlighting EPA’s potential beyond lipid lowering, emphasizing its impact on plaque stabilization and immune modulation, which are critical in preventing cardiovascular events! Stephen