With New Linker Technology, a New Approach to High-throughput Purification

With PurePep solutions, laboratories can work with purified peptides at any scale and throughput.

Access to purified peptides is one key element that can ensure trusted results—or cause complications. While peptide purification has always remained a critical process in drug screening, new PurePep® technology now allows a faster, more intuitive purification method for simple and complex peptides.  

Methods of the past, including conventional chromatographic purification, can take up valuable time and resources, which slows down the entire development process. Alternatively, the use of crude peptides compromises assay reliability. Both of these traditional methods continue to be bottlenecks in early-stage development. 

Orthogonal peptide purification with catch-and-release 

The orthogonal PEC purification technology easily removes peptide-related co- and close-eluting impurities that can cause false results through a catch-and-release methodology (Figure 1). This technology is available in our first universally applicable purification kits.   

Streamline and reduce costs in your laboratory during peptide purification for screenings 

Designed to overcome the limitations of conventional chromatography, PEC offers the best-in-class universally applicable parallel purification in a 96-well plate format. The parallel setup significantly reduces the cost of operation by more than 80% due to significantly reduced hands-on time (5 hours total per plate).  

By leveraging PEC technology in 96-well plates, researchers can achieve an average purity boost of 28% across multiple peptides using a simple, one-size-fits-all protocol.  

Trust high-quality, reliable assays featuring PEC-grade peptides 

PEC-grade peptides deliver reliable results in high-value preclinical research, as evidenced by Alphascreen® assays to study protein-protein interactions, shown by renowned research groups and published in peer-reviewed papers (S. Putta et al., Structure 2022, 30, p. 1) 

Webinar highlights

Watch the on-demand webinar to learn more about parallel peptide purification for faster and more reliable results:

• Get an understanding of peptide purity and how it affects assay reliability
• Gain an overview of current methods for parallel peptide purification
• Understand the basics of solvent-saving catch-and-release purification chemistry
• Learn how catch-and-release purification works in parallel, demonstrated for simple to complex peptides and peptide libraries

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