Oxalate containing foods cause thyroid issues.

How Oxalates Affect Thyroid Health

Preliminary research has linked oxalate buildup to thyroid disease.

While oxalate buildup has been predominantly tied to kidney stone formation, a study of thyroid autopsies found that 79 percent of adults had oxalate crystals in their thyroid glands, with prevalence increasing with age.

Interestingly, people with Hashimoto's had a lower incidence of oxalate crystals, especially in the parts of their thyroid gland that were inflamed!

This led the scientists to conclude that oxalates may play a role in contributing to Hashimoto's, potentially causing inflammation that may trigger the autoimmune response that, in turn, results in the destruction of the oxalate crystals and the surrounding thyroid tissue. In some cases, giant cell reactions were found around the crystals, suggesting an ongoing immune response.

Some believe that an oxalate-free diet is the only path to freedom from these symptoms, but I have found that in many cases, oxalates may need to be reduced in the short term and that there are underlying issues that can be addressed to resolve oxalate sensitivity!

Thus, for those of us with thyroid disease, it is important to recognize the role of oxalates and how we can address them.

What Are Oxalates?

Oxalates are naturally occurring molecules that are found in certain foods, and are also a waste product made by our bodies and excreted through our kidneys.

Oxalates form salts in the body by combining with calcium, after we consume foods that have a high oxalate content. When our body can't process the calcium-oxalate compounds, they crystallize and lodge in our organs, causing inflammation, which can turn into painful kidney stones and lead to other inflammatory symptoms of oxalate buildup in the body, such as joint pain, pain with urination/bowel movements, and even inflammation of the thyroid gland.

The top common foods with the highest oxalate content per serving include rhubarb, rice bran, buckwheat, almonds, miso soup, wheat berries, corn, potatoes, navy beans, beets, cocoa powder, and raspberries.

Primary and Secondary Hyperoxaluria

Oxalates are usually excreted from the body via urine.

A healthy range of oxalate excretion sits between 10-40 mg per day. Hyperoxaluria, or increased oxalate excretion, occurs when an individual excretes more than 40-45 mg of oxalates in a 24-hour window. It can contribute to the formation of kidney stones as well as other symptoms.

There are two different types of hyperoxaluria: primary hyperoxaluria and secondary hyperoxaluria.

Primary hyperoxaluria occurs when there is an inherited or genetic defect in the function of the enzymes that carry out oxalate metabolism. It is a rare genetic and metabolic disorder. (Within primary hyperoxaluria, there are three subtypes: types I, II, and III, each of which has a genetic defect in a different enzyme along the oxalate metabolism pathway.)

Secondary hyperoxaluria occurs due to non-genetic factors. Within secondary hyperoxaluria, there are two additional subtypes: dietary hyperoxaluria (caused by increased consumption of oxalate-containing foods) and enteric hyperoxaluria (caused by changes in the intestinal microbiome).

Secondary hyperoxaluria is more common in those with Hashimoto's, as this autoimmune condition is often associated with changes in the gut (intestinal) microbiome, and many people following thyroid-healing diets may consume a high amount of fruits/veggies that are high in oxalates.

How Do Oxalates Impact Thyroid Health?

Hyperoxaluria can indicate high levels of oxalates or oxalic (oxalate) buildup within the body.

As mentioned earlier, while oxalate buildup has been predominantly tied to kidney stone formation, a study of thyroid autopsies found that 79 percent of adults had oxalate crystals in their thyroid glands, with prevalence increasing with age. Interestingly, people with Hashimoto's had a lower incidence of oxalate crystals, especially in the parts of their thyroid gland that were inflamed!

This led the scientists to conclude that oxalates may play a role in contributing to Hashimoto's, potentially causing inflammation that may trigger the autoimmune response that, in turn, results in the destruction of the oxalate crystals and the surrounding thyroid tissue. In some cases, giant cell reactions were found around the crystals, suggesting an ongoing immune response.

A 2000 case report featured four people with a rare genetic disorder that resulted in oxalate buildup as well as the development of hypothyroidism. This report highlighted the role of oxalates in causing damage to the thyroid gland, and thus, hypothyroidism.

To complicate things further, a 2006 study reported that a person had developed excess oxalates due to hypothyroidism that was induced by amiodarone (one of the most thyroid toxic drugs)!

As such, it's important to look into identifying any potential underlying oxalate issues.

What Are the Symptoms of Oxalate Sensitivity?

Oxalate buildup or sensitivity should be suspected if you have any of the following symptoms (in addition to a thyroid condition like Hashimoto's or Graves’):

Joint pain

Pain in the body

Burning with urination

Interstitial cystitis

Burning with bowel movements

Leaky gut

Depression

Kidney stones

Root Causes of Oxalate Sensitivity

Oxalate sensitivity can be caused by various factors that result in the improper breakdown of oxalates in the body, such as a rare genetic disorder, any issues that affect the small intestine such as small intestinal bacterial overgrowth (SIBO) or small intestinal fungal overgrowth (SIFO), other kinds of gut dysbiosis (which can result from past antibiotic use), gastric surgery, Crohn's disease, and short bowel syndrome.

People with a low intake of calcium (such as those following a dairy-free diet, which is otherwise beneficial in Hashimoto's) may also have exacerbated oxalate issues. This is because calcium in our foods can reduce our absorption of oxalates.

As mentioned previously, changes in the intestinal microbiome can lead to secondary hyperoxaluria. Gut microbiome imbalances can result in a deficiency in the probiotic bacteria Oxalobacter formigenes, which has an enzyme known as "oxalyl-CoA decarboxylase" that breaks down oxalate. As such, a deficiency in Oxalobacter formigenes has also been connected with oxalate sensitivity.

The use of two specific antibiotics, erythromycin, and azithromycin (the popular "Z-pack"), is especially likely to cause a depletion of this bacteria. A 2011 study found that while 59 percent of people in the general population had a measurable level of Oxalobacter formigenes on stool tests, only 18 percent of past azithromycin users, and 26 percent of past erythromycin users, had this bacteria in their stools. In contrast, about 40 percent of Amoxicillin antibiotic users had the beneficial bacteria on stool tests.

Lastly, fungi (yeast and/or mold) overgrowth anywhere in the body can be a root cause of oxalate buildup, as certain kinds of fungi, such as Candida or Aspergillus, produce oxalates in a process called biomineralization. When there is an overgrowth of yeast or fungus, the excess amounts of oxalates that are emitted can lead to oxalate buildup and contribute to the symptoms mentioned above. In my experience, eliminating these pathogenic growths can eliminate or reduce oxalate issues.

How to Test for Oxalate Issues

In some cases, oxalates can cause kidney stones. From a conventional medicine standpoint, if you are currently passing kidney stones, the stones can be tested by your doctor to see if they contain calcium oxalate.

However, when looking through the lens of functional and root cause medicine (and whether you are currently passing kidney stones or not), I recommend a urine metabolite test.

While some individuals recommend a trial of a low oxalate diet to determine if oxalates are indeed causing your symptoms, a low oxalate diet can — in some cases — cause "oxalate dumping" (where too many oxalates try to leave your body all at once). This can increase symptoms. Additionally, an elimination diet will not find the root cause of the oxalate issues.

The Conventional Approach to Correcting Oxalate Buildup

The conventional approach to correcting oxalate buildup includes a combination of medications or prescription vitamins, some dietary changes, as well as corrective procedures, depending on the amount of buildup present and the cause.

If there is some buildup, but no kidney stones have formed yet, a prescription dose of vitamin B6 or potassium citrate is usually recommended. Thiazide diuretics are also recommended to help flush oxalates out of the kidneys. These prescription medications/vitamins can be especially helpful in the case of secondary hyperoxaluria.

For rare cases of type I primary hyperoxaluria, the FDA recently approved subcutaneous injections of a new drug, Oxlumo (lumasiran), as a potential treatment option. Oxlumo aims to target the genetic defects in primary hyperoxaluria that contribute to increased oxalate excretion and buildup.

The conventional approach also recommends dietary changes such as increasing water intake to flush out oxalates, as well as focusing on low oxalate foods.

If there is an excess amount of oxalates that have started to form kidney stones, there are two options. The first and least invasive option is to increase fluid intake to help the stones pass on their own. However, in some cases, a corrective procedure may be needed, so the second option consists of more invasive procedures, such as:

Shockwave lithotripsy, in which shock waves are sent through the water to break the stones apart in the affected area.

Ureteroscopy, in which a ureteroscope is inserted through the urethra to the ureter to either break the stones apart or retrieve and remove them.

Percutaneous nephrolithotomy, which is used as a last resort if the options above do not work. During this procedure, an incision is made in the back to access the kidneys directly and suction out the stones.

The Root Cause Approach to Correcting Oxalate Buildup

As mentioned earlier, while logic may suggest that we should limit all foods that contain oxalates, it's actually not ideal or realistic to stop them all at once. This is because in theory, stopping our intake of all oxalates can lead to a period of "oxalate dumping" and cause unpleasant symptoms.

That said, functional medicine lab tests are not available to everyone, so I want to share more about trialing the Low Oxalate Diet.

Low Oxalate Diet

It may be helpful to start with taking an inventory of your actual oxalate intake. The average diet contains 250 mg of oxalates per day, and if you are eating a significant amount above that, this can lead to oxalate symptoms simply because you are eating much more than you can break down. (That said, there can be more complicated, genetic reasons for the poor breakdown, such as primary hyperoxaluria, and more simple ones, such as B6 deficiency or yeast overgrowth.)

In the case of my client, who was "doing everything right", but continued to struggle with pain and urinary issues, we found that she had a yeast overgrowth in her body (through the OAT test). She had been eating a very high oxalate diet that included almond milk smoothies with spinach and chard, as well as a lot of beets.

Additionally, she had a poor sleep and poor dream recall, which are potential symptoms of B6 deficiency.

Addressing her yeast overgrowth, adding B6, and modifying her diet resolved her pain and urinary issues, as well as helped her sleep better.

In order to modify one's diet, it's helpful to be aware of common foods with the highest levels of oxalates, as well as foods with lower oxalate levels.

The foods with the highest oxalate content per serving (around 50 mg/serving or higher) include:

Dark leafy greens: spinach, kale, chard

Root vegetables: white/sweet potatoes, parsnips, beets, rutabaga

Other vegetables: carrots, celery, green peppers, Brussel sprouts

Fruit: oranges, avocados, kiwi, tomatoes, raspberries

Dried fruit: figs, dates

Nuts/seeds: almonds, walnuts, cashews, pumpkin, tahini

Grains: brown rice, buckwheat, wheat

Beverages: carrot juice, tomato juice, rice milk

Soy products

Legumes: navy beans, fava beans, lentils, refried beans, red kidney beans

Other: cocoa powder, stevia

The other foods that are commonly eaten on a Paleo diet and that have an oxalate content above 50 mg per serving include baked potatoes, beets, cocoa powder, and okra. Raspberries come in close, at 48 mg per serving!

There are also some foods that have an ultra-high oxalate content. However, we use them sparingly (like black pepper). These foods are usually not as much of a concern unless you are using more than 1 tsp at a time (that's a lot of pepper!).

Foods with moderate levels of oxalates (i.e., ranging between those found in high and low oxalate foods) include:

Fruits: apples, apricots, berries (except raspberries), peaches, grapefruit, plums

Grains: white rice

Nuts/seeds: sunflower seeds, pecans

Foods with low oxalate levels (less than 50 mg/serving) include:

Meats

Dairy: all dairy products (although dairy is not recommended for those with Hashimoto's)

Fruits: melons, mangoes, grapes, coconut

Vegetables: broccoli, cauliflower, cabbage, lettuce, mushrooms, onions, red peppers, cucumbers

Condiments: mustard, vinegar, mayonnaise

Sweeteners: honey, maple syrup

Beverages: herbal teas, apple juice, water, cider

As mentioned above, a standard diet takes in about 250 mg of oxalates per day. However, some people may choose to eat a low oxalate diet to prevent oxalate buildup. Consuming under 100 mg is recommended, but under 50 mg is ideal unless your doctor suggests otherwise.

In general, a helpful recommendation may be to start by eating moderate oxalate foods for one week (reduce your intake to less than 100 mg of oxalates per day). Let the body adjust, and then go to low oxalate foods (less than 50 mg of oxalates per day). When a higher oxalate food is consumed, it should be rotated to avoid over-concentration of oxalates and sensitivities to that food.

Once a person feels better, it's easy to slowly let high oxalate foods creep back in. These foods should always be rotated. If symptoms return, it's important to reduce oxalate intake immediately, to avoid possible stone formation.

Additional ways to support healing with oxalate sensitivities include:

Drinking plenty of fluids, mainly water, as this will help prevent kidney stones. Water will help dilute the substances found in urine, and therefore help prevent stones.

Adding a few slices of lemon to your water will not only flavor it, but will also help stop the formation of stones. This is because lemons contain citrate, which prevents oxalate buildup by binding to calcium.

Nutrients and Supplements

Probiotics and Enzymes

As mentioned previously, a deficiency in Oxalobacter formigenes can contribute to oxalate sensitivity. It is thus no surprise that a 1999 study by Sidhu and colleagues, demonstrated that supplementing with Oxalobacter formigenes, which acts as both a probiotic and enzyme, can help break down oxalates.

While Oxalobacter formigenes has the most studies behind it with respect to breaking down oxalates, lactic acid probiotics, Bifidobacterium lactis, Enterococcus faecali, and Eubacterium lentum also contain oxalyl-CoA decarboxylase and may help with breaking down oxalates.

Oxabact and Oxazyme are probiotic treatments that have both been clinically tested to significantly reduce oxalates by directly providing the probiotic O. formigenes (Oxabact) and by providing the enzyme that breaks down oxalates (Oxazyme). These enzymes are currently undergoing testing for efficacy and are available through clinical trials. They are currently in the third phase of testing and are one step closer to becoming available to the general public through pharmacies specializing in "orphan drugs" (as explained below).

That said, in researching this article, I was pleased to see that the probiotics and supplements I most commonly recommend can help with oxalate issues as well!

Addressing Gut Dysbiosis

As mentioned earlier, gut dysbiosis, especially yeast overgrowth, as well as SIBO and mold toxicity, can contribute to oxalate excess. One of the steps to correcting oxalate buildup is addressing this dysbiosis.

First things first, I recommend screening for yeast through the Great Plains Organic Acids Test. If this test does not find any yeast, mold, or bacterial abnormalities, I would then recommend testing for SIBO specifically, as SIBO is present in 50 percent of people with hypothyroidism, and addressing any dysbiosis is a necessary part of one's plan to overcome oxalate sensitivity.

I also recommend the GI-MAP stool test, which allows you to fully map and determine what microorganisms and/or pathogens are in your gut. This is a direct approach to determine whether there is a yeast/mold overgrowth or other gut dysbiosis present.

In the case that there is, removing triggering foods (such as high carbohydrates foods, to address Candida) and taking probiotics such as S. Boulardii by Rootcology, may promote a healthy gut. For more information, I encourage you to read my comprehensive articles on addressing Candida and mold toxicity.

The Takeaway

Oxalates are substances that are found to be particularly high in some foods. In excess amounts, oxalates can build up, leading to inflammation and the progression of autoimmune conditions, such as Hashimoto's.

Symptoms of oxalate buildup or sensitivity can range from joint pain to depression or kidney stones. Because the symptoms can be vague and overlap with other conditions, testing for oxalate buildup and/or sensitivity is important.

If there is buildup, there are steps you can take to reduce it and improve your health! These steps can include addressing your gut health, reducing oxalate-rich foods in your diet, increasing your water intake, and supplementing with B6, calcium, conjugated bile acids, and/or probiotics.

Most of my clients see a big reduction in their pain and other symptoms, once they start implementing these changes.

I hope that this information helps you improve your health!

God bless y’all 😊

Dr. Serge

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