Spotlight on Keto Research: Dec 6th 2024
Could ketogenic diets transform mental health care? Could a keto lifestyle ease the burden of type 1 diabetes management? Do intermittent fasting and fasting-mimicking diets shape metabolic health differently? This week’s Spotlight on Keto Research tackles these intriguing questions and more. Dive into the latest science below!
📌 Anderson et al. The Ketogenic Diet as a Transdiagnostic Treatment for Neuropsychiatric Disorders: Mechanisms and Clinical Outcomes
The ketogenic diet may provide a promising non-pharmacological option for mental health disorders by addressing underlying metabolic issues like mitochondrial dysfunction, oxidative stress, and glucose hypometabolism. This review highlights evidence from clinical trials and case reports showing its potential to improve symptoms in conditions such as schizophrenia, bipolar disorder, depression, and Alzheimer’s disease.
📌 Winje et al. Case report: Ketogenic diet alleviated anxiety and depression associated with insulin-dependent diabetes management
A ketogenic diet may help alleviate mental health challenges associated with living with type 1 diabetes. This case report details the experience of a 39-year-old woman who improved her glycemic control and mental health by adopting a ketogenic diet alongside insulin pump therapy. The approach significantly increased her time in range, reduced HbA1c, and eased diabetes distress, emphasizing the potential of ketogenic therapy in individualized diabetes care.
📌 Tilg et al. Adipokines: masterminds of metabolic inflammation
Adipokines, such as adiponectin and leptin, are signaling molecules released by adipose tissue and play a central role in driving metabolic inflammation. This review summarises how adipokines contribute to insulin resistance, liver disease, and cardiovascular complications by mediating immune responses and inter-organ communication. Additionally, it highlights the influence of diet, exercise, and gut health in shaping metabolic inflammation and their potential role in mitigating its effects.
📌 Michenthaler et al. Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
Intermittent fasting (IF) and fasting-mimicking diets (FMD) activated distinct systemic responses in mice, with short-term FMD driving more pronounced changes in blood markers and slightly greater weight loss. Both regimens activated similar transcriptional pathways, particularly PPARα signaling, although repeated FMD cycles attenuated responses related to fatty acid oxidation and ketogenesis. These findings provide valuable insights into the unique mechanisms of IF and FMD.
📌 Venditti et al. Rapid modulation of interscapular brown adipose tissue mitochondrial activity by ketosis induced by 1,3-butanediol administration to rats
β-hydroxybutyrate (BHB) may enhance brown adipose tissue (BAT) thermogenesis by modulating mitochondrial function. In this study the administration of the ketone precursor 1,3-butanediol (BD) in rats significantly elevated BHB levels, resulting in both rapid and sustained increases in mitochondrial activity and protein modifications in BAT. These findings highlight BHB's role as a signaling molecule, offering promising implications for targeting BAT in metabolic health interventions.
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