A timely diagnosis of Alzheimer’s disease
Dementia is now the leading cause of mortality in England and Wales. And the current trajectory predicts that the number of people over 60 living with dementia in the UK is expected to double in the next 25 years to reach 2 million by 2050 ( Alzheimer's Research UK ).
Dementia is an umbrella term encompassing a range of cognitive (e.g. memory impairment) and psychological (e.g. depression, anxiety, paranoia) symptoms that arise after substantial loss of brain cells. It is a late presentation of a number of different neurodegenerative diseases such as Parkinson’s, Huntington’s and Alzheimer’s; the latter being responsible for the majority (~60-70%) of cases ( World Health Organization 2022).
Alzheimer’s is a disease close to my heart. My grandfather passed away in 1995 from what was diagnosed as probable-Alzheimer’s disease based on his symptoms. ‘Probable’, because in the 90’s definitive diagnosis was only possible at autopsy. My family still vividly remembers the painful decline of a good-humoured, intelligent and much-loved father and grandfather. Sadly, stories like this are all too abundant.
A timely diagnosis
The definition of a timely diagnosis varies, but perhaps the broadest is ‘one made at the right time for the individual patient, irrespective of the disease stage’ (Dubois 2015). Currently diagnosis is most commonly made at the dementia stage, once a person can no longer continue to live their normal life. It’s hard to imagine how this can be the ‘right time’ for patients and their families.
Due to advances in science we now have the ability to accurately identify the protein signatures of Alzheimer’s (beta-amyloid and tau) during life by scans (amyloid-PET) or analysis of cerebrospinal fluid (CSF); a simple blood test is even on the horizon. Astonishingly, these biomarkers can actually be detected decades before the symptoms of dementia become apparent. This has led researchers to conclude that Alzheimer’s is in fact a disorder of middle age rather than old age (Ritchie et al 2015). This discovery offers a range of exciting opportunities for patients, families and our NHS.
Recommended by LinkedIn
The potential benefits of an early diagnosis include:
I’m not sure what my grandfather would have made of these advances in diagnosis and if, given the opportunity, he would have wished to know his risk whilst he was still fit and healthy, after all it remains a personal choice. However, a recent survey of the UK population found that the vast majority (74%) of people would want to know their diagnosis before they had symptoms of dementia ( Alzheimer's Research UK 2019). In any event, if we are going to realise the goal of making dementia a ‘very rare condition’ ( Craig Ritchie 2022), early diagnosis will definitely have a big part to play.
Working with you to overcome barriers to growing your healthcare and MedTech business
1yThanks for sharing your story, Ashton
CEO
1yReally enjoyed reading your interesting thoughts around your grandfather and pharmaceutical R&D