Vitamin B6

The effect of vitamin B6 deficiency on cytotoxic immune responses of T cells, antibodies, and natural killer cells, and phagocytosis by macrophages

By C Ha, L T Miller, and N I Kerkvliet

In a study conducted on 5-week-old female C57B1/6 mice, the effect on vitamin B6 on cytotoxic immune responses of T cells, cytotoxic antibody production, natural killer (NK) cells, and macrophage phagocytosis was evaluated. The mice were fed 20% casein diet with pyridoxine added at 7, 1, 0.1, or 0 mg/kg diet. In the experiment, animals fed 0 or 0.1 mg PN diet demonstrated significantly reduced primary splenic and peritoneal T-cell-mediated cytotoxicity (CMC), as well as against P815 tumor cells. Several things were not affected by the level of vitamin B6 intake including phagocytosis of SRBC by macrophages, complement-dependent antibody-meditated cytotoxicity against P815 cells, and native and interferon-induced NK cell activities against YAC cells. For the maintenance of normal T-cell function in vivo, these findings indicate that vitamin B6 is a vital nutrient. 

Citation:

C, Ha, L. T. Miller, and N. I. Kerkvliet. "The Effect of Vitamin B6 Deficiency on Cytotoxic Immune Responses of T Cells, Antibodies, and Natural Killer Cells, and Phagocytosis by Macrophages." Cellular Immunology. Accessed August 24, 2021. https://pubmed.ncbi.nlm.nih.gov/6608998/.