Chemical Biology #RSCChemBio

📢Issue 2 of Natural Product Reports is now online! Check out the articles in this month's issue here🔽 The #OpenAccess review providing the front cover comes from Hendrik Luesch & colleagues at the University of Florida discussing the progress in the discovery and development of anticancer agents from marine cyanobacteria 🔓https://lnkd.in/d8xS6HKW Also seen in this issue: A review on enzymatic ester bond formation strategies in fungal macrolide skeletons by Yi Zou et al. from Southwest University, part of the journal's Emerging Investigator collection 🔗https://lnkd.in/eWXGQxrC This #OpenAccess review from Julie Talbert & Steven Townsend at Vanderbilt University highlighting the current knowledge about the major classes of macromolecules in human milk and their potential role in infant health and wellness 🔓https://lnkd.in/et2FCRea A review on the chemical ecology and physiological functions of type I polyketide natural products by Kira J. Weissman & co. from the Universite de Lorraine 🔗https://lnkd.in/e2eijtsW The first Hot Off the Press article of 2025 from Robert Hill & Andrew Sutherland at the University of Glasgow on their selection of 32 recent papers covering the latest research in bioorganic chemistry and novel natural products 🔥https://lnkd.in/enHMVtmD This review providing an update on the chemistry and biology of natural stilbenes by Lanzhen Zhang, Yue Liu, Shuangcheng Ma & colleagues from the Beijing University of Chinese Medicine 🔗https://lnkd.in/e-JEumeY The latest iteration of the journal's annual Marine Natural Product review from Anthony (Tony) Carroll et al. at Griffith University, The University of Auckland, National Cancer Institute (NCI), Victoria University of Wellington & The University of Waikato covering the 2023 literature for marine natural products 🔓https://lnkd.in/evshNqB2

Our companion journal Chemical Science is delighted to launch the first Lectureship associated with the journal as part of our 15th year anniversary in 2025! This year, the Chemical Science editorial team are looking for researchers in the field of imaging, biosensing and diagnostics. https://lnkd.in/eatrbetG   The Chemical Science Lectureship will celebrate leading, independent researchers at all career stages and who have made innovations in their field within the last five years. The annual lectureship is focusing on a subject area that aligns with the next Chemical Science symposium, rotating each year to cover the diversity of topics published in the journal. Researchers must be independent and have published in Chemical Science within the last 5 years. There are no requirements to have received a PhD within a set period for this Lectureship; candidates will be considered for contributions within the past five years.   The winner will present their lectureship at the next Chemical Science symposium in November 2025 in a special Lectureship session, with associated travel costs included as part of the prize. They will also be invited to join the Chemical Science Advisory Board. Details about how to nominate are here: https://lnkd.in/eatrbetG   Nominations are open until the 1st of March 2025

Don't miss this study by Angela Wagner, Olivia Lanier, Ani Savk and Nicholas Peppas on polybasic nanogels for intracellular co-delivery of paclitaxel and carboplatin: a novel approach to ovarian cancer therapy. You can read their RSC Pharmaceutics publication for free: https://lnkd.in/eujT9Ag6

🚨Advance Article alert🚨 In this study, Yana Cen et al., reveal the biochemical characterization and inhibitor discovery of the Pf Sir2A enzyme, a key player in malaria progression. 🔗 Read the full article here: https://lnkd.in/eWrnMsb8 #DrugDiscovery #RSCChemicalBiology

Chemical Science is delighted to launch the first Lectureship associated with the journal as part of our 15th year anniversary in 2025! This year, we are looking for researchers in the field of imaging, biosensing and diagnostics. https://lnkd.in/eatrbetG The Chemical Science Lectureship will celebrate leading, independent researchers at all career stages and who have made innovations in their field within the last five years. The annual lectureship is focusing on a subject area that aligns with the next Chemical Science symposium, rotating each year to cover the diversity of topics published in the journal. Researchers must be independent and have published in Chemical Science within the last 5 years. There are no requirements to have received a PhD within a set period for this Lectureship; candidates will be considered for contributions within the past five years. The winner will present their lectureship at the next Chemical Science symposium in November 2025 in a special Lectureship session, with associated travel costs included as part of the prize. They will also be invited to join the Chemical Science Advisory Board. Details about how to nominate are here: https://lnkd.in/eatrbetG Nominations are open until the 1st of March 2025 and we look forward to receiving your nominations!

The Chemical biology symposium 2025 is just a few months away, and the poster abstract deadline is quickly approaching – submit your work and drive the conversation amongst peers and leading scientists 👨🔬 Submit your work by 3 March: rsc.li/cbs2025

📢Natural Product Reports is delighted to announce that the 41st iteration of the journal's annual Marine Natural Products review has been published #OpenAccess! The first Marine Natural Products review was published during the first year of the journal's existence in 1984 and has continued to be written annually since then. These reviews are comprehensive examinations of the marine natural product field covering the literature published each year in the area and have served to highlight the most important research trends in the community. This year's article covers the 2023 literature with an emphasis on the 1220 new compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, the submerged parts of mangroves and other intertidal plants. Pertinent reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, are also included. An analysis of the progress in the study of prokaryote involvement in macro-invertebrate marine natural product production is discussed. A big thank you to all the authors: Anthony (Tony) Carroll, Brent Copp, Tanja Grkovic, Robert Keyzers & Michele Prinsep 🔓Read the full article here🔽 https://lnkd.in/evshNqB2

📣New research published in RSC Chemical Biology by Jessie Zhang et al., from the The University of Texas at Austin uncovers how RPRD1B’s direct interaction with phosphorylated RNA polymerase II regulates polyadenylation of key cell cycle genes. 🔗 Dive into the full article: https://lnkd.in/e2wgtdyy #CancerResearch #RNAbiology #Polyadenylation #RSCChemicalBiolog

RSC Medicinal Chemistry issue 2 is out now! Be sure to read the work behind this month's covers and more in this issue👇 On the front cover is Eufrânio N. da Silva Júnior, John Bower and colleagues from Universidade Federal de Minas Gerais and University of Liverpool on the application of naphthoquinonyne chemistry for the synthesis of new compounds with potent trypanocidal activities, take a look👀⬇ 🔗 https://lnkd.in/eSh7cJGV This month's inside front cover features work by Vipan Kumar and colleagues from Guru Nanak Dev University, Amritsar on the synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials, read it here👏 🔗 https://lnkd.in/e_-b6Cd7 Also in this issue... An update on Target 2035 from Cheryl Arrowsmith, Stefan Knapp and colleagues covering the efforts of the EUbOPEN project which is contributing to the goals of #Target2035 (Target 2035)💡 🔗 https://lnkd.in/eRCwk-m8 A Review article by Dr. Avijit Kumar Das from Christ University, Bangalore on the advances in detecting non-steroidal anti-inflammatory drugs (NSAIDs) using molecular receptors and nanostructured assemblies, check it out⬇ 🔗 https://lnkd.in/eBRCxm74 🔓Don't miss this #OpenAccess Review by Fabricio Ramírez-Cortés and Petra Menova from University of Chemistry and Technology in Prague (UCT Prague) on the potential of asialoglycoprotein receptor (ASGPR)-mediated targeting in advancing liver-specific treatments👀 🔗 https://lnkd.in/eXq9pP7f 🔓Check out recent #OpenAccess research by Xiaoyu Zhang and colleagues from Northwestern University on exploiting the DCAF16–SPIN4 interaction to identify DCAF16 ligands for PROTAC development🔥 🔗 https://lnkd.in/e4Ux6ySU 🔓Be sure to ready #OpenAccess work by Carlo Santini, Valentina Gandin and colleagues from University of Camerino and Università degli Studi di Padova on the anticancer potential of Cu(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands ❗ 🔗 https://lnkd.in/eUugkytP Read recent work by Ruirui Wang, Chunyan Hu, Zewei Mao & co from Yunnan University of Chinese Medicine on the synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole 🔗 https://lnkd.in/enXWe_XR Enjoyed reading these articles? Check out the full issue, here: 📰https://lnkd.in/eis3R4Mb #RSCMedChem

Join us in London in April 2025 at the 𝑺𝒕𝒓𝒖𝒄𝒕𝒖𝒓𝒂𝒍 𝒂𝒏𝒅 𝒇𝒖𝒏𝒄𝒕𝒊𝒐𝒏𝒂𝒍 𝒂𝒔𝒚𝒎𝒎𝒆𝒕𝒓𝒚 𝒐𝒇 𝒑𝒍𝒂𝒔𝒎𝒂 𝒎𝒆𝒎𝒃𝒓𝒂𝒏𝒆𝒔 𝑭𝒂𝒓𝒂𝒅𝒂𝒚 𝑫𝒊𝒔𝒄𝒖𝒔𝒔𝒊𝒐𝒏 ❇ 📅Early bird registration deadline: 12 March 2025 🔗https://lnkd.in/eXpZK6zw This Discussion will explore the various facets of membrane asymmetry, bringing together experts in membrane physical chemistry, membrane biophysics, and membrane physiology. 𝗦𝗽𝗲𝗮𝗸𝗲𝗿𝘀: • Felix Goni, University of Basque Country, Spain • Markus Deserno, Carnegie Mellon University, United States • Erwin London, Stony Brook University, United States • Gerald W. Feigenson, Cornell University, United States •Heiko Heerklotz, University of Freiburg, Germany •Neha Kamat, Northwestern University, United States •Kandice Levental, University of Virginia , United States •Sylvie Roke, EPFL, Switzerland Royal Society of Chemistry #FDPLASMA