A collaboration between the Ohi and Smith labs at the LSI has revealed how two proteins of a larger complex interact to recognize and degrade viral RNA in the host cell. The findings provide the required foundation for understanding how other components interact with this core machinery to regulate its role in viral clearance. Read the study in PNAS: https://lnkd.in/eqpFMjyR
About us
The Life Sciences Institute explores biological processes, structures and functions at the finest scale to create impact on a global scale. We are a catalyst of discovery, combining cutting-edge tools, next-generation training, and inquisitive minds with diverse expertise and a shared purpose. With our multidisciplinary, collaborative approach, we bring together some of the most respected research programs in the world to push science forward with passion, energy, and urgency. From our work in chemical and structural biology to our breakthrough research in neuroscience and physiology, our ambitious pursuits lead us to ask big questions and demand bigger answers. Our next-level tools and research cores — including a high-throughput screening center, a unique natural products library and drug discovery core, and world-leading structural biology resources — advance new discoveries within the LSI and across the research enterprise of the entire university. And with a pipeline of educational programs for scientists from the high school through postdoctoral levels, we are preparing the next generation of scientific leaders.
- Website
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http://lsi.umich.edu
External link for U-M Life Sciences Institute
- Industry
- Research Services
- Company size
- 201-500 employees
- Headquarters
- Ann Arbor, Michigan
- Founded
- 1999
- Specialties
- basic science, biology, chemistry, natural products, and research
Updates
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A new study from Jun Wu’s lab at the LSI indicates that cross-organ communication between fat tissue and liver tissue can activate protective mechanisms against liver damage from alcohol consumption. The research, conducted in mice, provides new insights into the role of thermogenic fat in alcoholic liver disease. Read the study: https://lnkd.in/eT69Wpwk
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U-M Life Sciences Institute reposted this
The University of Michigan reported a record $2.04 billion in research volume during FY ‘24, a 9.9% increase compared to FY ’23. For more than a decade, U-M has ranked among the nation’s leading public universities in terms of research volume. Learn more about the innovative work accomplished by U-M researchers during FY ‘24: myumi.ch/pkEMz
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With new funding from the Milken Institute's Inaugural Kissick Family Foundation FTD Grant, Shyamal Mosalaganti and Sami Barmada will use advanced structural biology techniques to uncover new structural details of irregular proteins and determine how they malfunction in the brain to cause frontotemporal dementia.
Inaugural Kissick Family Foundation FTD Grant Program Awardees and Projects | Milken Institute
milkeninstitute.org
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In November 2023, the FDA approved the first therapeutic for a rare blood disorder called TTP. The research at the foundation of this treatment started in the lab of U-M physician scientist David Ginsburg. See the Innovation Partnerships 2024 Impact Report for more information on how a basic science question ultimately led to this approved treatment.
We are excited to share Innovation Partnerships’ Fiscal Year 2024 Impact Report! This year’s report highlights inspiring success stories from across the University of Michigan. Discover incredible startups and projects and learn about impactful researchers, including the 2024 Distinguished University Innovator of the Year, Kevin R. Ward, MD. Plus, celebrate another record-breaking year for research commercialization. Get the full story and read the report here: https://myumi.ch/5yXXA
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Scientists in the Mosalaganti lab have determined the structure of hSIDT1, a human protein involved in glucose tolerance, insulin secretion, tumor development and immune system activation. The research arose from a project supported by the LSI's Klatskin-Sutker Discovery fund, which encourages innovative, early-stage research that has potential to positively impact human health.
Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain
life-science-alliance.org
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Researchers from Peng Li's lab at the LSI have mapped the neural circuit that produces coughs in mice. Their study — featured on the cover of Nature Neuroscience — resolves the question of not only how mice cough, but whether they even exhibit this behavior.
Nature Neuroscience - A neural circuit for coughing
nature.com
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A team of LSI researchers has visualized the final step of a biological assembly line that produces macrolides, an important class of antibiotics commonly used to treat a range of bacterial infections such as pneumonia, tonsilitis and sexually transmitted infections. The discovery opens the door to tinkering with the machinery to build better antibiotics.
New view of a biological antibiotic assembly line reveals how machinery could be exploited to build better antibiotics
lsi.umich.edu