TITLE:
Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4-Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation
AUTHORS:
Khalid Hussain, Deepak Wadhwa
KEYWORDS:
Dihydropyridines, Iodobenzene Diacetate, Ultrasonic, Microwave, One-Pot, Formylpyrazoles
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.3,
September
11,
2014
ABSTRACT: A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.