TITLE:
Quantification of Steroid Receptors Gene Expression in Breast Cancer Patients: Possible Correlation with Serum Level of Adipocytokines
AUTHORS:
Rana Jahanban Esfahlan, Nosratollah Zarghami, Μohammad Rahmati-Yamchi, Amir Monfaredan, Samira Valiyari, Ali Jahanban Esfahlan, Raziallah Jafari Jozani, Morteza Gojazadeh, Fereidoun Mamaghani, Majid Mobasseri
KEYWORDS:
Obesity, Breast Cancer, Steroid Receptors, Adipocytokines
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.2 No.5,
December
31,
2011
ABSTRACT: Background: While the role of adipocyte-derived hormones in breast cancer pathogenesis well studied, it is speculated that there is a crosstalk between adipocytokines and Esterogen receptor(ER) signaling. To test this hypothesis we evaluate the possible correlation between serum levels of adipocytokins with steroid hormone receptors gene expression in breast cancer patients. Methods: In this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI 0.05). In case of leptin, we observed a positive correlation between leptin and ERα and PR mRNA. (r = 0.553, n = 64, p