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Nagoya is the fastest in Shinkansen in Osaka, 50 minutes, 6,560 yen, free seat. However, the Shinkansen only goes to Shin-Osaka. It takes about 10 minutes to transfer to JR Osaka. It takes about 10 minutes. From 6:00 in the morning to 19 in the evening, there is a class every 10 minutes. There is no problem in the round-trip.