What Is Paroxysmal Nocturnal Dyspnea (PND)?

Medically Reviewed by Sabrina Felson, MD on September 26, 2024
3 min read

You go to sleep. After a few hours, you wake up breathless and feeling like you’re suffocating. You sit upright and gasp for breath, and the feeling vanishes. If you’ve had this experience, you may have paroxysmal nocturnal dyspnea, or PND; a condition that is often connected to heart failure.

Paroxysmal means that the symptoms come on quickly and pass just as quickly. Nocturnal means that symptoms occur at night, and dyspnea is the medical term for breathing difficulties.

PND is a feeling of suffocation when you’re not engaging in any strenuous activity ⁠— like when you’re sleeping ⁠— and it is a classic sign of heart failure and you should be evaluated. However, dyspnea is not always related to the heart, so talk to your doctor to get an appropriate and accurate diagnosis.

Some patients may experience bronchospasm, or a narrowing and obstruction of the respiratory airway similar to asthma.

You don’t always feel relief immediately after you sit upright. Your body can take half an hour, or more, to normalize.

Other symptoms include:

  • Suddenly waking up with a cough or wheezing
  • Having a faster than usual heart rate
  • Feeling the need to open the window to get more air
  • Sleep anxiety
  • Insomnia
  • A tendency to want to sleep in a chair

Other signs of heart failure include leg swelling, shortness of breath when walking, and weight gain.

‌PND is caused by heart failure, specifically failure of the left-sided large of the heart. When this happens, it is unable to pump as much blood as the right ventricle, which is functioning normally. As a result, you experience pulmonary congestion, a condition in which fluid fills the lungs.

The condition occurs in patients with left and right ventricular heart failure and increased pulmonary fluid pressure. People with medical factors that can cause airway resistance, such as asthma, COPD, and congestive heart failure, are at risk.

It is also thought that decreased responsiveness in the part of your brain responsible for respiration during sleep is a contributing factor. PND episodes are also associated with the normally occurring decrease in your heart’s fight-or-flight response that happens when you fall asleep.

Other causes include:

  • Respiratory muscle dysfunction
  • Decreased respiratory muscle strength
  • Decreased endurance
  • Reduced blood flow through the heart
  • Increased carbon dioxide production
  • Complications from high blood pressure

It’s believed that fluid accumulation in the lining of the airways causes the shortness of breath during an episode of PND.‌‌‌

Although the causes are well understood, the exact factors that trigger a PND episode are still unknown.

‌‌‌What it’s like to have PND

PND can be a terrifying condition. Patients report that, during episodes, they felt that they were going to die. If you’ve never previously experienced symptoms of heart failure, it can be made even worse, because you don’t know what’s happening in the moment. And, of course, you experience sleep loss.

Make a point of keeping track of your symptoms and the ways that they affect your life. You may want to start keeping a diary with details of PND attacks and how you manage your symptoms.

Your doctor may run tests to establish the cause of your PND. Your doctor will likely start their work up with blood tests and an echocardiogram. Additional studies may subsequently be needed to make a diagnosis. 

You might receive a chest CT scan, chest X-rays, a heart MRI, or other diagnostic tests.

In many cases, PND is a symptom of worsening heart failure. Your doctor may prescribe common treatments for heart failure, like diuretics, which are medications that make you pee more to help get rid of more salt and water.

If, in rare cases, you have severe heart failure and your doctor can’t find a treatment option for you, you may need a heart transplant.

Lifestyle changes that improve heart health may be helpful. Some good heart-healthy habits are.

  • Quitting smoking
  • Eating a low-fat diet that contains lots of fruits, whole grains, vegetables, and lean proteins, while cutting back on your total salt intake
  • Limiting your alcohol consumption
  • Getting regular exercise
  • Managing your stress