GRAVIOLA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Graviola (Annona muricata) is a small tree native to tropical regions. It makes edible fruit and has been used traditionally for parasite infections.

Graviola contains chemicals that might help fight against cancer, as well as bacteria, viruses, and parasites.

People use graviola for human papilloma virus (HPV), bacterial infections, cancer, and many other conditions, but there is no good scientific evidence to support these uses. It also might be unsafe.

Uses & Effectiveness

We currently have no information for GRAVIOLA overview.

Side Effects

When taken by mouth: Graviola is possibly unsafe. Taking larger amounts of the fruit or regularly drinking tea made from the leaves has been linked to movement disorders similar to Parkinson disease.

Special Precautions and Warnings

Pregnancy and breast-feeding: Do not use graviola. It is possibly unsafe when taken by mouth.

Parkinson disease: Graviola might make the symptoms of Parkinson disease worse.

Interactions

Moderate Interaction

Be cautious with this combination

Carbamazepine (Tegretol) interacts with GRAVIOLA
Graviola may reduce how much carbamazepine is in the body. Taking graviola with carbamazepine might decrease the effects of this medication.

Dosing

There isn't enough reliable information to know what an appropriate dose of graviola might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Champy, P., Hoglinger, G. U., Feger, J., Gleye, C., Hocquemiller, R., Laurens, A., Guerineau, V., Laprevote, O., Medja, F., Lombes, A., Michel, P. P., Lannuzel, A., Hirsch, E. C., and Ruberg, M. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J.Neurochem. 2004;88(1):63-69. View abstract.

Lannuzel, A., Hoglinger, G. U., Champy, P., Michel, P. P., Hirsch, E. C., and Ruberg, M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? J.Neural Transm.Suppl 2006;(70):153-157. View abstract.

Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. View abstract.

Atlas RO, Lemus J, Reed J 3rd, Atkins D, Alger LS. Second trimester abortion using prostaglandin E2 suppositories with or without intracervical Laminaria japonica: a randomized study. Obstet Gynecol. 1998 Sep;92(3):398-402 View abstract.

Bonneau N, Le Ven J, Schmitz-Afonso I, et al. Annonaceous acetogenins as environmental neurotoxins: Human exposure from edible Annona fruits. Planta Med. 2012;78:PH25. Abstract only.

Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. View abstract.

Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. View abstract.

dos Santos AF, Sant'Ana AE. Molluscicidal properties of some species of Annona. Phytomedicine 2001;8:115-20.. View abstract.

Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835-48. View abstract.

Hansra DM, Silva O, Mehta A, Ahn E. Patient with metastatic breast cancer achieves stable disease for 5 years on graviola and xeloda after progressing on multiple lines of therapy. Adv Breast Cancer Res. 2014;3:84-7.

Indrawati L, Ascobat P, Bela B, Abdullah M, Surono IS. The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pac J Clin Nutr. 2017;26(4):606-12.View abstract.

Jaramillo MC, Arango GJ, Gonzalez MC, et al. Cytotoxicity and antileishmanial activity of Annona muricata pericarp. Fitoterapia 2000;71:183-6. View abstract.

La Vignera S, Basile L, Aversa A, et al. The Use of Ellagic Acid and Annona Muricata Improves Semen Quality in Men with High-Risk Papillomavirus Infection. J Clin Med 2022;11(16):4691. View abstract.

Lannuzel A, Michel PP, Caparros-Lefebvre D, et al. Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord 2002;17:84-90. View abstract.

Le Donne M, Lentini M, Alibrandi A, et al. Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial. J Funct Food 2017;35:549-54.

Moghadamtousi SZ, Fadaeinasab M, Nikzad S, Mohan G, Ali HM, Kadir HA. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities. Int J Mol Sci. 2015 Jul 10;16(7):15625-58. doi: 10.3390/ijms160715625. View abstract.

Moscato GMF, Galanti F, Criscuolo AA, et al. A retrospective study on two cohorts of immunocompetent women treated with nonavalent HPV vaccine vs. Ellagic acid complex: outcome of the evolution of persistent cervical HPV infection. Eur Rev Med Pharmacol Sci 2022;26(15):5509-5519. View abstract.

Oberlies NH, Chang CJ, McLaughlin JL. Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. J Med Chem 1997;40:2102-6. View abstract.

Padma P, Pramod NP, Thyagarajan SP, Khosa RL. Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus. J Ethnopharmacol 1998;61:81-3. View abstract.

Raveloson Ravaomanarivo LH, Andrianiaina Razafindraleva H, Raharimalala FN, Rasoahantaveloniaina B, Ravelonandro PH, Mavingui P. Efficacy of seed extracts of Annona squamosa and Annona muricata (Annonaceae) for the control of Aedes albopictus and Culex quinquefasciatus (Culicidae). Asian Pac J Trop Biomed. 2014;4(10):798-806.

Roman G. Tropical myeloneuropathies revisited. Curr Opin Neurol 1998;11:539-44. View abstract.

Serretta V, Berardinis E, Simonato A, et al. A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis. Urologia. 2021 Jun 2:3915603211022285. View abstract.

Sokpe A, Mensah MLK, Koffuor GA, et al. Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products. Evid Based Complement Alternat Med. 2020 Dec 10;2020:8833828. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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