CISSUS QUADRANGULARIS: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Cissus quadrangularis is a vine that grows in Africa and parts of Asia. Traditionally, its plant parts are dried and made into powder to use as medicine.

Cissus quadrangularis might have antioxidant, pain-relieving, and anti-inflammatory effects. It might also help stimulate bone growth.

People use Cissus quadrangularis for obesity, fractures, joint pain, low bone mass, and many other conditions, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness

Possibly Effective for

Obesity. Taking Cissus quadrangularis extract by mouth, alone or with other ingredients, seems to help reduce body weight in people who are overweight or obese.

There is interest in using Cissus quadrangularis for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Cissus quadrangularis is possibly safe when used for up to 10 weeks. It's usually well-tolerated. Side effects might include headache, diarrhea, and insomnia.

Special Precautions and Warnings

When taken by mouth: Cissus quadrangularis is possibly safe when used for up to 10 weeks. It's usually well-tolerated. Side effects might include headache, diarrhea, and insomnia.

Pregnancy and breast-feeding: There isn't enough reliable information to know if Cissus quadrangularis is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Surgery: Cissus quadrangularis might lower blood sugar levels and could interfere with blood sugar control during and after surgical procedures. Stop using Cissus quadrangularis at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with CISSUS QUADRANGULARIS
Cissus quadrangularis might lower blood sugar levels. Taking Cissus quadrangularis along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Dosing

Cissus quadrangularis extract has most often been used by adults in doses of 300 mg by mouth daily for up to 10 weeks. Powdered whole herb and dried stem products have also been used. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

REFERENCES:

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Bhujade, A. M., Talmale, S., Kumar, N., Gupta, G., Reddanna, P., Das, S. K., and Patil, M. B. Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators. J Ethnopharmacol. 6-14-2012;141(3):989-996. View abstract.

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Chidambaram, J. and Carani, Venkatraman A. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet. Food Chem Toxicol. 2010;48(8-9):2021-2029. View abstract.

Chopra, S. S., Patel, M. R., and Awadhiya, R. P. Studies of Cissus quadrangularis in experimental fracture repair : a histopathological study. Indian J Med Res 1976;64(9):1365-1368. View abstract.

Chopra, S. S., Patel, M. R., Gupta, L. P., and Datta, I. C. Studies on Cissus quadrangularis in experimental fracture repair: effect on chemical parameters in blood. Indian J Med Res 1975;63(6):824-828. View abstract.

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Jainu M, Shyamala Devi CS. In Vitro and In Vivo Evaluation of Free-Radical Scavenging Potential of Cissus quadrangularis. Pharmaceutical Biology 2005;43(9):773-779.

Jainu, M. and Devi, C. S. Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer-a comparative study with sucralfate. J Med Food 2004;7(3):372-376. View abstract.

Jainu, M. and Mohan, K. V. Protective role of ascorbic acid isolated from Cissus quadrangularis on NSAID induced toxicity through immunomodulating response and growth factors expression. Int.Immunopharmacol. 12-20-2008;8(13-14):1721-1727. View abstract.

Jainu, M. and Shyamala Devi, C. S. Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis. J Herb.Pharmacother. 2005;5(3):33-42. View abstract.

Jainu, M., Mohan, K. V., and Devi, C. S. Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats. J Ethnopharmacol. 4-6-2006;104(3):302-305. View abstract.

Jainu, M., Vijaimohan, K., and Kannan, K. Cissus quadrangularis L. extract attenuates chronic ulcer by possible involvement of polyamines and proliferating cell nuclear antigen. Pharmacogn.Mag. 2010;6(23):225-233. View abstract.

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Muthusami, S., Senthilkumar, K., Vignesh, C., Ilangovan, R., Stanley, J., Selvamurugan, N., and Srinivasan, N. Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. J Cell Biochem 2011;112(4):1035-1045. View abstract.

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Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai. 2010;93(12):1360-1367. View abstract.

Parisuthiman, D., Singhatanadgit, W., Dechatiwongse, T., and Koontongkaew, S. Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts. In Vitro Cell Dev.Biol.Anim 2009;45(3-4):194-200. View abstract.

Potu, B. K., Bhat, K. M., Rao, M. S., Nampurath, G. K., Chamallamudi, M. R., Nayak, S. R., and Muttigi, M. S. Petroleum ether extract of Cissus quadrangularis (Linn.) enhances bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis. Clinics.(Sao Paulo) 2009;64(10):993-998. View abstract.

Potu, B. K., Nampurath, G. K., Rao, M. S., and Bhat, K. M. Effect of Cissus quadrangularis Linn on the development of osteopenia induced by ovariectomy in rats. Clin Ter. 2011;162(4):307-312. View abstract.

Potu, B. K., Rao, M. S., Kutty, N. G., Bhat, K. M., Chamallamudi, M. R., and Nayak, S. R. Petroleum ether extract of Cissus quadrangularis (LINN) stimulates the growth of fetal bone during intra uterine developmental period: a morphometric analysis. Clinics.(Sao Paulo) 2008;63(6):815-820. View abstract.

Potu, B. K., Rao, M. S., Nampurath, G. K., Chamallamudi, M. R., Nayak, S. R., and Thomas, H. Anti-osteoporotic activity of the petroleum ether extract of Cissus quadrangularis Linn. in ovariectomized Wistar rats. Chang Gung.Med J 2010;33(3):252-257. View abstract.

Potu, B. K., Rao, M. S., Nampurath, G. K., Chamallamudi, M. R., Prasad, K., Nayak, S. R., Dharmavarapu, P. K., Kedage, V., and Bhat, K. M. Evidence-based assessment of antiosteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. on ovariectomy-induced osteoporosis. Ups.J Med Sci 2009;114(3):140-148. View abstract.

PRASAD, G. C. and UDUPA, K. N. EFFECT OF CISSUS QUADRANGULARIS ON THE HEALING OF CORTISONE TREATED FRACTURES. Indian J Med Res 1963;51:667-676. View abstract.

Shah, U. M., Patel, S. M., Patel, P. H., Hingorani, L., and Jadhav, R. B. Development and Validation of a Simple Isocratic HPLC Method for Simultaneous Estimation of Phytosterols in Cissus quadrangularis. Indian J Pharm.Sci 2010;72(6):753-758. View abstract.

Shanthi G, Vijay kanth G Hitesh L Ganesan M. Antiulcerogenic activities of the methanolic extract of Cissus quadrangularis in wistar. Internet Journal of Toxicology 2010;7(2)

Shirwaikar, A., Khan, S., and Malini, S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. J Ethnopharmacol. 2003;89(2-3):245-250. View abstract.

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Srisook, K., Palachot, M., Mongkol, N., Srisook, E., and Sarapusit, S. Anti-inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-kappaB activation. J Ethnopharmacol. 2-16-2011;133(3):1008-1014. View abstract.

Thawani VR, Kimmatkar N Hingorani LL Khiyani RM. Effect of herbal combination containing cissus quadrangularis in fracture healing. The Antiseptic 2002;99(9):345-347.

UDUPA, K. N. and PRASAD, G. BIOMECHANICAL AND CALCIUM-45 STUDIES ON THE EFFECT OF CISSUS QUADRANGULARIS IN FRACTURE REPAIR. Indian J Med Res 1964;52:480-487. View abstract.

UDUPA, K. N. and PRASAD, G. C. FURTHER STUDIES ON THE EFFECT OF CISSUS QUADRANGULARIS IN ACCELERATING FRACTURE HEALING. Indian J Med Res 1964;52:26-35. View abstract.

UDUPA, K. N., ARNIKAR, H. J., and SINGH, L. M. Experimental studies of the use of 'cissus quadrangularis' in healing of fractures. II. Indian J Med Sci 1961;15:551-557. View abstract.

Viswanatha Swamy, A. H., Kulkarni, R. V., Thippeswamy, A. H., Koti, B. C., and Gore, A. Evaluation of hepatoprotective activity of Cissus quadrangularis stem extract against isoniazid-induced liver damage in rats. Indian J Pharmacol. 2010;42(6):397-400. View abstract.

Bah S, Jager AK, Adsersen A, et al. Antiplasmodial and GABA(A)-benzodiazepine receptor binding activities of five plants used in traditional medicine in Mali, West Africa. J Ethnopharmacol 2007;110:451-7. View abstract.

Barakat SEM, Adam SEI, Maglad MA, Wasfi IA. Effects of Cissus quadrangularis on goats and sheep in Sudan. Rev Elev Med Vet Pays Trop 1985;38:185-94. View abstract.

Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;101:154115. View abstract.

Bloomer RJ, Farney TM, McCarthy CG, Lee SR. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study. Phys Sportsmed 2013;41(3):29-35. View abstract.

Brahmkshatriya HR, Shah KA, Ananthkumar GB, Brahmkshatriya MH. Clinical evaluation of Cissus quandrangularis as osteogenic agent in maxillofacial fracture: a pilot study. Ayu 2015;36(2):169-73. View abstract.

Dhatrak S, Thawani V, Gharpure K, et al. Effect of herbal combination in low bone mass density patients. International Journal of Drug Discovery and Technology 2011;2(1):9-14.

Jadhav AN, Rafiq M, Devanathan R, et al. Ketosteroid standardized Cissus quadrangularis L. extract and its anabolic activity: time to look beyond ketosteroid? Pharmacogn Man 2016;12(Suppl 2):S213-7. View abstract.

Jainu M, Devi CS. Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage. Chem Biol Interact 2006;161:262-70. View abstract.

Jainu M, Mohan KV, Devi CSS. Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res 2006;123:799-806. View abstract.

Kuate D, Nash RJ, Bartholomew B, Penkova Y. The use of Cissus quadrangularis (CQR-300) in the management of components of metabolic syndrome in overweight and obese participants. Nat Prod Commun 2015;10(7):1281-6. View abstract.

Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106. View abstract.

Niwatananun K, Niwatananun W, Piyamongkol S, et al. Clinical pilot study of rectal suppository containing combined extract of Cissus quadrangularis Linn. and Acmella paniculata (Wall ex. DC.) R. K. Jansen in acute hemorrhoids. Evid Based Complement Alternat Med 2021;2021:5605323. View abstract.

Oben J, Enyegue DM, Fomekong G, et al. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis 2007;6:4. View abstract.

Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24. View abstract.

Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12. View abstract.

Panthong A, Supraditaporn W, Kanjanapothi D, et al. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. J Ethnopharmacol 2007;110:264-70. View abstract.

Pg G, Chugh A, Chaudhry K, et al. Comparison of Teriparatide and Combination of Cissus Quadrangularis and Dalbergia Sissoo on Bone Healing Against the Control Group in Maxillofacial Fractures: A Randomized Open-label Control Trial. Craniomaxillofac Trauma Reconstr 2023;16(1):23-33. View abstract.

Sawangjit R, Puttarak P, Saokaew S, Chaiyakunapruk N. Efficacy and safety of Cissus quadrangularis L. in clinical use: a systematic review and meta-analysis of randomized controlled trials. Phytother Res 2017;31(4):555-67. View abstract.

Siddaram A, Neetu J, Uttam N, et al. Management of colle's fracture by Asthishrangularis (Cissus quadrangularis Linn): a clinical study. Int Research J Pharmacy 2012;3(10):164-8.

Singh G, Rawat P, Maurya R. Constituents of Cissus quadrangularis. Nat Prod Res 2007;21:522-8. View abstract.

Singh N, Singh V, Singh RK, et al. Osteogenic potential of Cissus quadrangularis assessed with osteopontin expression. Natl J Maxillofac Surg 2013;4(1):52-6. View abstract.

Stohs SJ, Ray SD. A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts. Phytother Res 2013;27(8):1107-14. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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