MAITAKE MUSHROOM: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Maitake (Grifola frondose) is a type of mushroom. It forms large clumps on tree stumps and tree roots. It was first used in Asian traditional medicine.

Maitake mushroom grows in forests in Asia, Europe, and eastern North America. It contains chemicals that might help fight tumors, stimulate the immune system, and lower blood sugar levels.

People use maitake mushroom for enlarged ovaries with cysts, diabetes, and many other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using maitake mushroom for COVID-19.

Uses & Effectiveness

We currently have no information for MAITAKE MUSHROOM overview.

Side Effects

When taken by mouth: Maitake mushroom is possibly safe for most people. But there isn't much information about potential side effects. Some people have reported nausea after taking maitake mushroom.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if maitake mushroom is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Surgery: Maitake mushroom might affect blood sugar levels, making blood sugar control difficult during and after surgery. Stop using maitake mushroom at least 2 weeks before a scheduled surgery.

Interactions

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with MAITAKE MUSHROOM
Maitake mushroom might lower blood sugar levels. Taking maitake mushroom along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Warfarin (Coumadin) interacts with MAITAKE MUSHROOM
Maitake mushroom might increase the blood thinning effects of warfarin and potentially increase the chance of bleeding. Your healthcare provider may need to monitor you more often if you take maitake mushroom along with warfarin. The dose of your warfarin medication may need to be changed.
Medications for high blood pressure (Antihypertensive drugs) interacts with MAITAKE MUSHROOM
Maitake mushroom might lower blood pressure. Taking maitake mushroom along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Dosing

An extract of maitake mushroom has most often been used by adults in a dose of 1-1.5 grams by mouth daily for up to 2 years. There isn't enough reliable information to know what an appropriate dose of maitake mushroom in other forms might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Adachi, K., Nanba, H., Otsuka, M., and Kuroda, H. Blood pressure-lowering activity present in the fruit body of Grifola frondosa (maitake). I. Chem.Pharm.Bull.(Tokyo) 1988;36(3):1000-1006. View abstract.

Adachi, Y., Ohno, N., and Yadomae, T. Activation of murine kupffer cells by administration with gel-forming (1-->3)-beta-D-glucan from Grifola frondosa. Biol Pharm Bull 1998;21(3):278-283. View abstract.

Adachi, Y., Okazaki, M., Ohno, N., and Yadomae, T. Enhancement of cytokine production by macrophages stimulated with (1-- >3)-beta-D-glucan, grifolan (GRN), isolated from Grifola frondosa. Biol Pharm Bull 1994;17(12):1554-1560. View abstract.

Bae, J. T., Sim, G. S., Lee, D. H., Lee, B. C., Pyo, H. B., Choe, T. B., and Yun, J. W. Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiol.Lett 10-15-2005;251(2):347-354. View abstract.

Chang, R. Functional properties of edible mushrooms. Nutr Rev 1996;54(11 Pt 2):S91-S93. View abstract.

Cui, F. J., Li, Y., Xu, Y. Y., Liu, Z. Q., Huang, D. M., Zhang, Z. C., and Tao, W. Y. Induction of apoptosis in SGC-7901 cells by polysaccharide-peptide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Toxicol In Vitro 2007;21(3):417-427. View abstract.

Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J.Cancer Res.Clin.Oncol. 2009;135(9):1215-1221. View abstract.

Fukushima, M., Ohashi, T., Fujiwara, Y., Sonoyama, K., and Nakano, M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood.) 2001;226(8):758-765. View abstract.

Fullerton, S. A., Samadi, A. A., Tortorelis, D. G., Choudhury, M. S., Mallouh, C., Tazaki, H., and Konno, S. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol Urol 2000;4(1):7-13. View abstract.

Gu, C. Q., Li, J. W., Chao, F., Jin, M., Wang, X. W., and Shen, Z. Q. Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa. Antiviral Res 2007;75(3):250-257. View abstract.

Gu, C. Q., Li, J., and Chao, F. H. Inhibition of hepatitis B virus by D-fraction from Grifola frondosa: synergistic effect of combination with interferon-alpha in HepG2 2.2.15. Antiviral Res 2006;72(2):162-165. View abstract.

Hong, L., Xun, M., and Wutong, W. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. J Pharm Pharmacol 2007;59(4):575-582. View abstract.

Horio, H. and Ohtsuru, M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol.(Tokyo) 2001;47(1):57-63. View abstract.

Inoue, A., Kodama, N., and Nanba, H. Effect of maitake (grifolafrondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull 2002;25(4):536-540. View abstract.

Ishibashi, K., Miura, N. N., Adachi, Y., Ohno, N., and Yadomae, T. Relationship between solubility of grifolan, a fungal 1,3-beta-D- glucan, and production of tumor necrosis factor by macrophages in vitro. Biosci Biotechnol Biochem 2001;65(9):1993-2000. View abstract.

Kidd, P. M. The use of mushroom glucans and proteoglycans in cancer treatment. Altern.Med Rev. 2000;5(1):4-27. View abstract.

Kodama, N., Komuta, K., and Nanba, H. Can maitake MD-fraction aid cancer patients? Altern.Med Rev 2002;7(3):236-239. View abstract.

Kurashige, S., Akuzawa, Y., and Endo, F. Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N- butanolnitrosoamine. Immunopharmacol.Immunotoxicol. 1997;19(2):175-183. View abstract.

Li, X., Rong, J., Wu, M., and Zeng, X. [Anti-tumor effect of polysaccharide from Grifola frondosa and its influence on immunological function]. Zhong.Yao Cai. 2003;26(1):31-32. View abstract.

Lin, J. T. and Liu, W. H. o-Orsellinaldehyde from the submerged culture of the edible mushroom Grifola frondosa exhibits selective cytotoxic effect against Hep 3B cells through apoptosis. J Agric Food Chem 10-4-2006;54(20):7564-7569. View abstract.

Manohar, V., Talpur, N. A., Echard, B. W., Lieberman, S., and Preuss, H. G. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes.Metab 2002;4(1):43-48. View abstract.

Matsui, K., Kodama, N., and Nanba, H. Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis. Cancer Lett 10-30-2001;172(2):193-198. View abstract.

Mayell, M. Maitake extracts and their therapeutic potential. Altern Med Rev 2001;6(1):48-60. View abstract.

Miura, N. N., Ohno, N., Aketagawa, J., Tamura, H., Tanaka, S., and Yadomae, T. Blood clearance of (1-->3)-beta-D-glucan in MRL lpr/lpr mice. FEMS Immunol Med Microbiol 1996;13(1):51-57. View abstract.

Nanba, H. Maitake D-fraction: Healing and preventing potentials for cancer. Townsend Letter for Doctors & Patients 1996;151/152:84-85.

Ohno, N., Egawa, Y., Hashimoto, T., Adachi, Y., and Yadomae, T. Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice. Biol Pharm Bull 1996;19(4):608-612. View abstract.

Okazaki, M., Adachi, Y., Ohno, N., and Yadomae, T. Structure-activity relationship of (1-->3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro. Biol Pharm Bull 1995;18(10):1320-1327. View abstract.

Preuss, H. G., Echard, B., Bagchi, D., Perricone, N. V., and Zhuang, C. Enhanced insulin-hypoglycemic activity in rats consuming a specific glycoprotein extracted from maitake mushroom. Mol.Cell Biochem 2007;306(1-2):105-113. View abstract.

Sanzen, I., Imanishi, N., Takamatsu, N., Konosu, S., Mantani, N., Terasawa, K., Tazawa, K., Odaira, Y., Watanabe, M., Takeyama, M., and Ochiai, H. Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7. J Exp Clin Cancer Res 2001;20(4):591-597. View abstract.

Sliva, D. Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini.Rev.Med Chem. 2004;4(8):873-879. View abstract.

Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern.Med.Rev. 2006;11(2):128-150. View abstract.

Suzuki, I., Hashimoto, K., Oikawa, S., Sato, K., Osawa, M., and Yadomae, T. Antitumor and immunomodulating activities of a beta-glucan obtained from liquid-cultured Grifola frondosa. Chem Pharm Bull (Tokyo) 1989;37(2):410-413. View abstract.

Suzuki, I., Itani, T., Ohno, N., Oikawa, S., Sato, K., Miyazaki, T., and Yadomae, T. Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa. J Pharmacobiodyn. 1984;7(7):492-500. View abstract.

Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. View abstract.

Tanaka, H., Tsunematsu, K., Nakamura, N., Suzuki, K., Tanaka, N., Takeya, I., Saikai, T., and Abe, S. Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol. Intern.Med. 2004;43(8):737-740. View abstract.

Wu, M. J., Cheng, T. L., Cheng, S. Y., Lian, T. W., Wang, L., and Chiou, S. Y. Immunomodulatory properties of Grifola frondosa in submerged culture. J Agric.Food Chem 4-19-2006;54(8):2906-2914. View abstract.

Yang, B. K., Gu, Y. A., Jeong, Y. T., Jeong, H., and Song, C. H. Chemical characteristics and immuno-modulating activities of exo-biopolymers produced by Grifola frondosa during submerged fermentation process. Int J Biol Macromol. 8-1-2007;41(3):227-233. View abstract.

Yang, D., Li, S., Wang, H., Li, X., Liu, S., Han, W., Hao, J., and Zhang, H. [Prevention of postoperative recurrence of bladder cancer: a clinical study]. Zhonghua Wai Ke.Za Zhi. 1999;37(8):464-465. View abstract.

Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull (Tokyo) 1987;35:262-70. View abstract.

Aguilera-Braico DM, Balogh GA. CD3? immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice. BMC Res Notes 2022;15(1):307. View abstract.

Aoki H, Hanayama M, Mori K, Sato R. Grifola frondosa (Maitake) extract activates PPARd and improves glucose intolerance in high-fat diet-induced obese mice. Biosci Biotechnol Biochem. 2018;82(9):1550-1559. View abstract.

Borchers AT, Stern JS, Hackman RM, et al. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 1999;221:281-293. View abstract.

Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med 2010;16:1295-9. View abstract.

Han C, Cui B. Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation. Inflammation 2012;35(4):1269-75. View abstract.

Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. View abstract.

Hu Q, Xie B. Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial. Acta Biochim Pol 2022;69(3):625-632. View abstract.

Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. View abstract.

Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. View abstract.

Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. View abstract.

Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull 1994;17:1106-10. View abstract.

Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Alt Ther Health Med 1996;2:62-6. View abstract.

Nanba H, Kubo K. Effect of Maitake D-fraction on cancer prevention. Ann N Y Acad Sci 1997;833:204-7. View abstract.

Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann N Y Acad Sci 1995;768:243-5. View abstract.

Pan YY, Zeng F, Guo WL, et al. Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats. Food Funct. 2018;9(12):6268-6278. View abstract.

Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is licensed from Therapeutic Research Center, LLC. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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MAITAKE MUSHROOM - Uses, Side Effects, and More

Overview

Uses & Effectiveness

Side Effects

Special Precautions and Warnings

Interactions

Moderate Interaction

Medications for diabetes (Antidiabetes drugs) interacts with MAITAKE MUSHROOM

Warfarin (Coumadin) interacts with MAITAKE MUSHROOM

Medications for high blood pressure (Antihypertensive drugs) interacts with MAITAKE MUSHROOM

Dosing

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