Cryptobiotix

🔬  Promising preclinical alleviation of dysbiosis in non-breastfed infants with Cow’s Milk Protein Allergy (CMPA) 🔬   📢 We are thrilled to announce our latest publication in gut microbiome research, in collaboration with Nestlé Health Science published in Beneficial Microbes.   🌐 Contributing to applied research with the potential to improve the quality of life of infants made this study particularly rewarding. We utilised the predictive, ex vivo SIFR technology to evaluate the potential of HMOs-lactose combinations to address dysbiosis in CMPA infants. Leveraging the high throughput of this validated methodology, 12 donors were included to map interpersonal differences.   📊 Key findings for lactose addition to HMO formulae: - stronger SCFA production - stimulation of HMO-utilising Bifidobacteriaceae and reduction in Clostridiaceae - stronger production of health-related metabolites pertaining to gut-brain axis, immune health, and gut motility   📈  We are happy to share those promising results, that will need to be confirmed in clinical trials.   🤝🏼 Thank you to all authors for your contribution: Pieter Van den Abbeele, Ralf Heine, Michiel Van de Vliet, Laurent Favre, Hanne Tytgat, Norbert Sprenger, Stef Deyaert, Aurélien Baudot and Sophie Nutten. Read the full study here: https://lnkd.in/eC_nt34Q #GutHealth #GutMicrobiome #MicrobiomeResearch #PreclinicalDataYouCanTrust #infants #research #exvivo #preclinical

🚀 Next stop: London, for animal health and nutrition!   🔍 After a buzzing Probiota, we’re heading straight to London for the Animal Health, Nutrition & Technology Innovation Europe conference!.  Whether you are looking at companion or production animals, we’re eager to help develop your next gut health products! 🐷🐔🐱🐶 🔬 We're dedicated to the 3R’s principles – Replacement, Refinement, and Reduction - aiming to minimise unnecessary animal trials and provide predictive data.   🔗 Meet with Aurélien Baudot to discuss how we can support your science-driven product development and elucidate the mechanism of action along the way. #GutHealth #preclinical #research #gutmicrobiome #microbiome

Spotlight on microbiome and probiotic research: #Probiota awaits! 🌟 🚀 Excited to kick off 2025 by attending Probiota in Copenhagen! Our team will be present in full force, with no fewer than four colleagues joining the event. We look forward to reconnecting with all our customers and hearing the latest from the industry. 🔍 From ideation and screening to the in-depth characterisation of your lead #Probiotics, #Prebiotics, #Synbiotics and #Postbiotics, we can help you understand the mechanism of action of your actives with a unique precision and clarity. By delivering preclinical data you can trust, the SIFR technology fast-tracks your gut microbiome research, helps you secure IP and de-risks your clinical trials. 🔗 Book a meeting with Aurélien Baudot, Ingmar van Hengel, PhD, Frederik Van Leemputte and Pieter Van den Abbeele, or meet with us during the conference to learn more about our digestive and gut microbiome expertise. #GutHealth #GutMicrobiome #MicrobiomeResearch #PreclinicalDataYouCanTrust NutraIngredients

🚀 Excited to announce Ingmar van Hengel, PhD is becoming our Director of Business Development! 🦠 You have met him in recent years while discussing our SIFR technology and preclinical gut microbiome studies, at conferences and remotely. Ingmar’s hard work, positive energy, and unwavering dedication have made a real impact on our team. We’re thrilled to see him take on this new challenge and help further our customers! 📈 Congrats, Ingmar – looking forward to what’s ahead!

🚀 Excited to kick off 2025 with a new publication! 📆  📑 We are adding a new page to the previous study on 🥕 carrot-derived rhamnogalacturonan cRG-I, as we now investigated its metabolic impact in a large-scale preclinical study. NutriLeads leveraged the unique predictivity and throughput of our SIFR technology and investigated their #prebiotic in the #gutmicrobiome of no less than 24 healthy adults. 🌟 Key takeaways 🌟  - cRG-I stimulates the production of indole-3-propionic acid (IPA) consistently in all donors 📈  - IPA is a potent antioxidant linked to  🫄 gut, 🛡️ immune, 💓 heart and 🧠 brain health  - this happens through 🦠 B. longum enrichment, mirroring observations from prior clinical results Thank you for the continued trust and the great collaboration, NutriLeads and co-authors Annick Mercenier, Lam Dai Vu, Jonas Poppe, Ruud Albers, Sue Mckay, and Pieter Van den Abbeele. 🔗 Link in comments #PreclinicalDataYouCanTrust #GutHealth #Preclinical #research #exvivo #microbiomeresearch

🔬 𝗘𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝗡𝗲𝘄 𝗦𝘁𝘂𝗱𝘆 𝗳𝗿𝗼𝗺 𝗡𝘂𝘁𝗿𝗶𝗟𝗲𝗮𝗱𝘀! 📰 Our latest study reveals that Benicaros®, our precision prebiotic made from upcycled carrot pomace, significantly boosts the production of 𝗶𝗻𝗱𝗼𝗹𝗲-𝟯-𝗽𝗿𝗼𝗽𝗶𝗼𝗻𝗶𝗰 𝗮𝗰𝗶𝗱 (𝗜𝗣𝗔) — 𝗮 𝗽𝗼𝘄𝗲𝗿𝗳𝘂𝗹 𝗮𝗻𝘁𝗶𝗼𝘅𝗶𝗱𝗮𝗻𝘁 𝗹𝗶𝗻𝗸𝗲𝗱 𝘁𝗼 𝗴𝘂𝘁, 𝗶𝗺𝗺𝘂𝗻𝗲, 𝗵𝗲𝗮𝗿𝘁, 𝗮𝗻𝗱 𝗯𝗿𝗮𝗶𝗻 𝗵𝗲𝗮𝗹𝘁𝗵! ♛Study Highlights:♛ 🔹 Benicaros is a precision prebiotic with consistent effects across all donors. 🔹 Modulates the production of health-related microbial metabolites beyond SCFAs. 🔹 Reduces the production of harmful metabolites. 🔹 Stimulates IPA production, strongly correlated with increased Bifidobacterium longum. A big thank you to our co-authors, especially Dr. Pieter Van den Abbeele, CSO of Cryptobiotix and Dr. Annick Mercenier, for their invaluable contributions to this groundbreaking research! Curious about how Benicaros could transform health and wellness? Dive into the full study and discover more about the potential of our plant-based precision prebiotic! 🔗 Read more here: https://lnkd.in/e5_wxqTg #GutHealth #PrecisionPrebiotic #Innovation #Benicaros #CryptoBiotics #NutriLeads #NutritionScience #GutMicrobiome

✈️Back to Boston for 2 days of full immersion in the latest microbiome developments!✈️   It is a busy week for the team: Fi Europe, the Future of Microbiome summit, and now also the Microbiome Connect conference. Join our CEO Aurélien Baudot  for an insightful chat. He is eager to discuss how to fast-track your product development through #PreclinicalDataYouCanTrust. The SIFR technology pipeline was designed to de-risk your clinical trials, and help you substantiate your claims, through: 🚀 #Highthroughput investigation across products and individuals 📈 Advanced #dataanalysis for maximal insight generation 🔬 Validated predictivity to minimise your risks in moving to the next step Let's connect and explore the future of gut microbiome research together! #research #GutHealth #GutMicrobiome #MicrobiomeResearch #Preclinical #exvivo #SIFR #invitro

🦠We will share some insights about cutting-edge preclinical research🦠 🗣️ Register and listen to the presentation of our CSO Pieter Van den Abbeele, addressing the unmet needs for predictive preclinical research during the Future of the Microbiome Winter summit. 📅 When? 20 Nov, 9.45 am CST / 4.45 pm CET 🔗 How to access? Register through the following link: https://lnkd.in/gvKmDRep Thank you Global Prebiotic Association for the opportunity to share theses insights with the microbiome community. #Nutrition #research #GutHealth #GutMicrobiome #MicrobiomeResearch #Preclinical #exvivo #SIFR #invitro #PreclinicalDataYouCanTrust

🥕Eager to hear about the latest functional food trends on a global scale🥒    🚄 Meet our BD manager Ingmar van Hengel, PhD, at Food ingredients Europe next week. He is eager to discuss how to valorise your functional food ingredients. How? By generating #PreclinicalDataYouCanTrust about their impact on the microbiome and gut health. Our SIFR technology pipeline was designed to de-risk your clinical trials, and help you substantiate your claims, through: 🚀 #Highthroughput investigation across products and individuals 📈 Advanced #dataanalysis for maximal insight generation 🔬 Validated predictivity to minimise your risks in moving to the next step Let's connect and explore the future of food technology, nutrition, and gut microbiome research together!  #Nutrition #research #GutHealth #GutMicrobiome #MicrobiomeResearch #Preclinical #exvivo #SIFR #invitro 

📢 Restoring microbiota away from Bact2 status might improve intestinal barrier function in UC.   📊 We’re happy to share the latest publication of our very own Jonas Poppe. The altered faecal water metabolome in ulcerative colitis impacts functionally the colonic epithelium. Read the linked article to get all the details.