inscreenex GmbH

Paper Spotlight: Staphylococcus aureus uses lipid raft-mediated endocytosis to slip into lung epithelial cells, effectively hiding from the immune system and dodging circulating antibiotics. And our huBroBEC lung epithelial cells were one of the in vitro model systems used to investigate the mechanism. Disrupting these lipid rafts with methyl-β-cyclodextrin significantly reduces S. aureus internalization. Confocal microscopy even showed the bacteria co-localizing with lipid raft markers like ganglioside GM1 and caveolin-1. What's really interesting is the role of alpha-hemolysin (Hla). Even when S. aureus can still adhere to cells via fibronectin-binding proteins and α5β1 integrin, without Hla, its ability to get inside the cells is greatly impaired. Caveolin-1 seems essential here, while ADAM10 doesn't play a significant role. This points to a promising therapeutic angle: targeting the lipid rafts or the Hla–caveolin-1 interaction could enhance the effectiveness of our current treatments against S. aureus respiratory infections. Congrats to Oliver Goldmann, Julia Lang, Manfred Rohde, Gabriella Molinari and Eva Medina from Helmholtz Centre for Infection Research and our very own Tobias May for a great paper!

Thank you #BioEurope2024!We celebrated your 30th birthday with 3 intense but fruitful days. We met a lot of wonderful new people and had the opportunity to catch up with existing friends. Looking forward to the next BioEurope in beautiful Vienna. #Inscreenex Anne Dittrich Inga Hochnadel Dr. Christoph Schröder Konstantin Bagnjuk Katarzyna Tkocz Thomas Schirrmann Reyk Horland Dr. Yash D. Patel Dr. Sami Ullah Julia Lang Linda Kirchner

We’re excited to join forces with Cytion to make our cell lines more accessible to researchers around the globe! As the first step in our collaboration, our stable cells overexpressing in-demand oncology targets are now available in the Cytion catalogue for commercial and non-profit customers worldwide, in addition to our own catalogue. Stay tuned for more news coming soon!

Join Tobias in Barcelona at PEGS Europe, the largest protein and antibody engineering event in Europe. Discuss at our Poster A063 how our CHO-BXB landing pad cell line can move your antibody discovery forward.

Anne and Theresa will be partnering at #BIOEurope in Stockholm next week...and they will also be celebrating BIO-Europe's 30 year anniversary. See you in Stockholm!

Our immortalized alveolar cells played a pivotal role in two recent cutting-edge organ-on-chip research papers. The cells were key components in in vitro models of the deep lung with OoC technologies coming from AlveoliX and TissUse GmbH. These innovative models offers a promising alternative to animal testing and hold significant potential for advancing cancer research. Congratulations to our colleagues Clémentine Richter, Patrick Carius, Nicole Schneider-Daum, Claus-Michael Lehr, Janick Stucki, Nina Hobi and colleagues from Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Vitrocell Systems GmbH, Universität des Saarlandes and ARTORG Center for Biomedical Engineering Research for their paper in Bioengineering and Translational Medicine and @Christiano Fieni, @Stefania Livia Ciummo, @Emma Di Carlo and colleagues from University Chieti and University of Rome. #organonchip #cancer #alternativestoanimal

Currently on a surprisingly smooth Deutsche Bahn train ride home - only a 6-minute delay (yet!) - Tobias is making his way back from the Festival of Biologics in Basel, and we wanted to share some highlights: Basel truly shines as a biotech and life science event location: easy to reach, excellent public transport, a fantastic venue, and a vibrant scientific community (Roche, Novartis, Actelion...) Biologics are making waves everywhere. Sanofi just today announced a €300 million investment for a 16% equity stake in radiopharma company Orano Med, which uses...drumroll...peptides and antibodies to target alpha emitters directly to cancer cells. And here's a hot take: autoimmunity apparently is the new oncology?! #FoB #FestOfBiologics

Only a few days until the Festival of Biologics in Basel! Tobias will be there discussing how our cell lines can help your biologics drug discovery - in particular our new Llama landing pad cell line for VHH discovery. #festofbiologics #FoB

Our huFIB immortalized fibroblasts took the center stage in this new paper by Robin Van den Eynde and colleagues! They created a new optical add-on module for fluorescence microscope called the "Circulator" and imaged our fibroblasts using the Massive Photonics and GATTAquant - DNA Nanotechnologies DNA-PAINT Kit. The Circulator enables simultaneous multicolor and full field-of-view acquisitions of single molecules and thereby increases the imaging information content and throughput of single-molecule or sparse imaging at very minimal costs. Congrats to the whole team! Fabian Hertel, Sergey Abakumov, Bartosz Krajnik, Siewert Hugelier, Alexander Auer, Joschka Hellmeier, Thomas Schlichthärle, Rachel Grattan, Diane Lidke, Ralf Jungmann, Marcel Leutenegger, Wim Vandenberg and Peter Dedecker. See the full paper: https://lnkd.in/eznT3ptY

maybe someone in our network is interested in this opportunity