Age Breaker

WE WISH YOU AN EXCELLENT YEAR 2025 ✨ The Zebra finch is a bird native to the Sunda Islands. It measures and weighs about 3.9 inches and 0.02 lbs. Its life span in good health exceeds 10 years, a world record on this scale! It has the particularity of naturally resisting glycation... #zebrafinch #sundaislands #birds #glycation #naturalresistance #excellentyear #2025 #healthylife #nativebird #longevity #zebrafinchlife #birdfacts #agebreaker

𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐚𝐠𝐢𝐧𝐠 𝐚𝐧𝐝 𝐬𝐮𝐠𝐚𝐫: 𝐝𝐚𝐦𝐧𝐢𝐧𝐠 𝐧𝐞𝐰 𝐞𝐯𝐢𝐝𝐞𝐧𝐜𝐞! The use of “epigenetic clocks” demonstrates that sugar consumption is indeed responsible for accelerated aging. Epigenetic age provides precise information on cellular aging. Based on epigenetic modifications of DNA, and in particular methylation, it enables highly accurate assessment of the risk of developing age-related diseases and accelerated aging. Epigenetic age is determined by assessments of DNA methylation levels in the body, known as “epigenetic clocks”. A recent study shows for the first time that sugar consumption is associated with epigenetic aging, which will inevitably lead to accelerated aging (1). Conversely, and logically, a healthy diet is associated with a younger epigenetic age. The predictive power of “epigenetic clocks” on aging, and their accuracy, offer the possibility of evaluating lifestyle interventions (diet, exercise, sleep...) that will enable us to take control of aging. © AGE Breaker 11 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/IH6nG #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1) : CHIU, Dorothy T., HAMLAT, Elissa June, ZHANG, Joshua, et al. Essential nutrients, added sugar intake, and epigenetic age in midlife Black and White women: NIMHD Social Epigenomics Program. JAMA Network Open, 2024, vol. 7, no 7, p. e2422749-e2422749. Doi:10.1001/jamanetworkopen.2024.22749

𝐄𝐱𝐩𝐨𝐬𝐮𝐫𝐞 𝐭𝐨 𝐜𝐨𝐥𝐝, 𝐚𝐠𝐢𝐧𝐠 𝐚𝐧𝐝 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦 - 𝐰𝐡𝐚𝐭'𝐬 𝐧𝐞𝐰? Moderate exposure to low temperatures may improve longevity. For some animal species, exposure to low temperatures, allowing the body to cool down very slightly (around 0.5 degrees Celsius), appears to have a positive effect on longevity (1). Conversely, regular exposure to extreme cold has a negative physiological impact, even in healthy people. Studies show that the improvement in longevity associated with exposure to cold is due in particular to an improvement in glucose metabolism in response to cold (2). Provided it remains moderate, exposure to cold could be a strategy for preventing certain aging factors, such as metabolic imbalances. © AGE Breaker 12 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/1iU8JOg #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1): Lee, H.J., Alirzayeva, H., Koyuncu, S. et al. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nat Aging 3, 546–566 (2023). https://swll.to/ZB4xe (2): IVANOVA, Yoanna M. et BLONDIN, Denis P. Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes. Journal of Applied Physiology, 2021, vol. 130, no 5, p. 1448-1459. https://swll.to/k7x0yem

Aging, sugar and glycation: 𝐃𝐢𝐞𝐭𝐚𝐫𝐲 𝐟𝐢𝐛𝐞𝐫𝐬, 𝐚𝐧𝐭𝐢-𝐚𝐠𝐢𝐧𝐠 𝐰𝐞𝐚𝐩𝐨𝐧𝐬! By slowing the rate of sugar absorption, dietary fibers help control glycation and thus prevent aging. Dietary fiber, a complex carbohydrate, is not digested by the body. They are mainly found in fruits, vegetables, legumes and cereals. Numerous studies have demonstrated the benefits of dietary fiber in combating obesity, preventing age-related diseases such as diabetes, cardiovascular disease and certain cancers (1). Several mechanisms of action are invoked to explain these benefits (2). Among them, fiber, by slowing the rate of carbohydrate absorption, helps control and lower blood glucose levels. Similarly, studies have shown a correlation between dietary fiber intake and low glycation levels (3). Combined with a low-glycemic diet, dietary fiber is an excellent way to promote healthy aging. As the Western diet is low in fiber, it is recommended to increase its intake by consuming legumes and whole grains in particular. AGE Breaker, updated 12 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/eTC8h #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts 1 MORIMOTO, Nobuhisa, URAYAMA, Kevin Y., TANAKA, Akira, et al. Relationship between dietary fiber to carbohydrate ratio and mortality risk in US adults: NHANES 2007–2018. Nutrition, Metabolism and Cardiovascular Diseases, 2024, vol. 34, no 3, p. 661-671. https://swll.to/RArIGU 2 WADDELL, Isabella Skye et ORFILA, Caroline. Dietary fiber in the prevention of obesity and obesity-related chronic diseases: From epidemiological evidence to potential molecular mechanisms. Critical reviews in food science and nutrition, 2023, vol. 63, no 27, p. 8752-8767. https://swll.to/inD7eh 3 DEMIRCI, Bahar Gürlek, TUTAL, Emre, EMINSOY, Irem O., et al. Dietary fiber intake: its relation with glycation end products and arterial stiffness in end-stage renal disease patients. Journal of Renal Nutrition, 2019, vol. 29, no 2, p. 136-142. https://swll.to/5x2qG

𝐋𝐨𝐰 𝐠𝐥𝐲𝐜𝐞𝐦𝐢𝐜 𝐢𝐧𝐝𝐞𝐱 𝐝𝐢𝐞𝐭, 𝐭𝐡𝐞 𝐚𝐧𝐭𝐢-𝐚𝐠𝐢𝐧𝐠 𝐬𝐭𝐫𝐚𝐭𝐞𝐠𝐲! A low-glycemic diet prevents glycation and promotes healthy aging. The glycemic index classifies foods according to their effect on blood sugar levels after ingestion. Numerous studies show that a low glycemic index diet, such as the Mediterranean diet, is systematically associated with a lower risk of developing age-related diseases, diabetes, cardiovascular disease and accelerated aging (1) & (2). The explanation: a diet with a high glycemic index leads to a systemic accumulation of glycation-derived AGEs in the body (2). Conversely, a low-glycemic index diet, by reducing glycation accumulation, promotes healthy aging (3). © AGE Breaker, updated 11 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/fEmE8bZ #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1) JENKINS, David JA, DEHGHAN, Mahshid, MENTE, Andrew, et al. Glycemic index, glycemic load, and cardiovascular disease and mortality. New England Journal of Medicine, 2021, vol. 384, no 14, p. 1312-1322. Doi: 10.1056/NEJMoa2007123 (2) HU, Frank B. Diet strategies for promoting healthy aging and longevity: An epidemiological perspective. Journal of internal medicine, 2024, vol. 295, no 4, p. 508-531. https://swll.to/nnTul (3) ROWAN, Sheldon, BEJARANO, Eloy, et TAYLOR, Allen. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2018, vol. 1864, no 12, p. 3631-3643. Doi: 10.1016/j.bbadis.2018.08.036

𝐀𝐠𝐢𝐧𝐠 𝐚𝐧𝐝 𝐠𝐥𝐲𝐜𝐚𝐭𝐢𝐨𝐧. 𝐅𝐫𝐮𝐜𝐭𝐨𝐬𝐞: 𝐭𝐡𝐞 𝐬𝐰𝐞𝐞𝐭 𝐝𝐞𝐚𝐭𝐡! Fructose, the super-fuel of glycation, is a particularly harmful sugar. For many years, fructose and glucose, which have the same chemical formula, were considered identical in their effects on health. For the record, glucose is the main carbohydrate in animals, while sucrose (composed of glucose and fructose) is the main carbohydrate in plants. As fruit has always been a staple of the human diet, fructose has long been considered beneficial to human health. Its superior sweetening power to other sugars reinforced this attraction. Throughout the ages, refined sugar from plants with a high fructose content has even become a luxury commodity for many populations. Numerous studies show that fructose is one of the most harmful sugars: - It participates more rapidly than glucose in the glycation reaction, a major cause of aging and age-related diseases (1). - Its complex and deleterious metabolism leads to numerous metabolic disorders (2). Thus, its excessive consumption is associated with the development of pancreatic cancer (3). Consumption of refined sugar, and therefore fructose, exploded worldwide during the 20th century. The predictable consequence: a boom in diseases such as diabetes, cardiovascular diseases, digestive system cancers, neurodegenerative diseases and, more generally, accelerated aging... © AGE Breaker, updated 11 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/Igcw6A #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts 1 : JANG, Cholsoon, HUI, Sheng, LU, Wenyun, et al. The small intestine converts dietary fructose into glucose and organic acids. Cell metabolism, 2018, vol. 27, no 2, p. 351-361. e3. https://swll.to/eevbS 2 : FEBBRAIO, Mark A. et KARIN, Michael. “Sweet death”: fructose as a metabolic toxin that targets the gut-liver axis. Cell metabolism, 2021, vol. 33, no 12, p. 2316-2328. doi:10.1016/j.cmet.2021.09.004. WANG, Chengqiang, WANG, Lu, ZHAO, Qing, et al. Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer. Cell Death & Differentiation, 2024, p. 1-11. https://swll.to/OpOWYv

𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐚𝐠𝐢𝐧𝐠 𝐚𝐧𝐝 𝐬𝐮𝐠𝐚𝐫: 𝐝𝐚𝐦𝐧𝐢𝐧𝐠 𝐧𝐞𝐰 𝐞𝐯𝐢𝐝𝐞𝐧𝐜𝐞! The use of “epigenetic clocks” demonstrates that sugar consumption is indeed responsible for accelerated aging. Epigenetic age provides precise information on cellular aging. Based on epigenetic modifications of DNA, and in particular methylation, it enables highly accurate assessment of the risk of developing age-related diseases and accelerated aging. Epigenetic age is determined by assessments of DNA methylation levels in the body, known as “epigenetic clocks”. A recent study shows for the first time that sugar consumption is associated with epigenetic aging, which will inevitably lead to accelerated aging (1). Conversely, and logically, a healthy diet is associated with a younger epigenetic age. The predictive power of “epigenetic clocks” on aging, and their accuracy, offer the possibility of evaluating lifestyle interventions (diet, exercise, sleep...) that will enable us to take control of aging. © AGE Breaker 11 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/2tFod8 #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1) : CHIU, Dorothy T., HAMLAT, Elissa June, ZHANG, Joshua, et al. Essential nutrients, added sugar intake, and epigenetic age in midlife Black and White women: NIMHD Social Epigenomics Program. JAMA Network Open, 2024, vol. 7, no 7, p. e2422749-e2422749. Doi:10.1001/jamanetworkopen.2024.22749

𝐒𝐮𝐠𝐚𝐫 𝐚𝐧𝐝 𝐚𝐠𝐢𝐧𝐠: 𝐟𝐫𝐨𝐦 𝐜𝐨𝐧𝐭𝐫𝐨𝐯𝐞𝐫𝐬𝐲 𝐭𝐨 𝐞𝐯𝐢𝐝𝐞𝐧𝐜𝐞! Sugar consumption associated with dementia risk, new evidence. “Pure, white and deadly, how sugar is killing us”, this 1972 publication by British physiologist John Yudkin, following many years of research, was the first warning against the health effects of sugar consumption. Curiously, his ideas were rejected at the time. Information later revealed that, at the same time, the industrial sugar lobby was funding studies drawing attention to the dangers of fat consumption and minimizing those of sugar. Since then, global sugar production has increased 4-fold! A large-scale study (following a cohort of over 210,000 people), the largest conducted to date, shows that daily consumption of dietary sugar is significantly associated with the risk of all-cause dementia and Alzheimer's disease (1). After the links demonstrated between sugar consumption, cardiovascular disease and metabolic disorders, this study confirms the key role played by sugar in the rise of age-related diseases. Today, despite the evidence, the sugar controversy persists, with researchers and public health advocates on one side denouncing the dangers of sugar, and the industrial sugar lobby on the other, seeking to trivialize the risks associated with sugar with misleading slogans such as “consume in moderation”. And yet we must stop eating sugar, and without moderation! © AGE Breaker 11 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/RdPsQnb #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1) : ZHANG, Sirui, XIAO, Yi, CHENG, Yangfan, et al. Associations of sugar intake, high-sugar dietary pattern, and the risk of dementia: a prospective cohort study of 210,832 participants. BMC medicine, 2024, vol. 22, no 1, p. 298. https://swll.to/fIA9FH

𝐀𝐠𝐢𝐧𝐠, 𝐬𝐭𝐫𝐞𝐬𝐬, 𝐦𝐚𝐬𝐬𝐚𝐠𝐞 𝐚𝐧𝐝 𝐠𝐥𝐲𝐜𝐚𝐭𝐢𝐨𝐧: 𝐬𝐨𝐦𝐞𝐭𝐡𝐢𝐧𝐠 𝐧𝐞𝐰. Already recognized for combating chronic stress, therapeutic massage would improve glycation, a major factor in accelerated aging. Prolonged exposure to stress factors leads to chronic stress which, via complex mechanisms including glycation, promotes accelerated aging and age-related diseases. Statistics show that, in the Western world, 9 out of 10 people experience chronic stress at least once in their lives. Japanese researchers have shown that therapeutic massage using a microcurrent-generating device was significantly associated with an improvement in glycation, a major factor in aging. The hypothesis is that the increase in cutaneous blood flow induced by the microcurrents generated by the device is the cause of the reduction in glycation (1). Improved sleep, release of endorphins (pleasure hormones), massage is known for its effects against stress. Combined with its beneficial effects on blood circulation, massage therapy is proving to be an effective tool in the fight against accelerated aging and the onset of age-related illnesses. © AGE Breaker 10 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/E1JnE #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1): KUROSAKA, S., YANAOKA, T., KANEMOTO, N., et al. The Effects of Neo Healer Massage on Advanced Glycation End Products in Middle-Aged and Older Individuals. Journal of Science and Medicine in Sport, 2024, vol. 27, p. S15-S16. DOI: 10.1016/j.jsams.2024.08.165

𝐏𝐫𝐞𝐯𝐞𝐧𝐭𝐢𝐧𝐠 𝐚𝐠𝐢𝐧𝐠: 𝐋𝐢𝐟𝐞𝐬𝐭𝐲𝐥𝐞 𝐨𝐫 𝐝𝐫𝐮𝐠𝐬? Studies show that intensive lifestyle intervention is more effective than medication in preventing age-related diseases and accelerated aging. Abdominal overweight is a warning sign of metabolic syndrome, itself a precursor of diabetes and, more generally, accelerated aging. It's easy to identify subjects at risk, monitor them and measure the effectiveness of strategies preventing accelerated aging. Studies conducted by the National Diabetes Prevention Program in the United States on at-risk populations over long periods of time show that preventive use of geroprotective drugs such as metformin an reduce the onset of diabetes by around 30% (1). The same studies show that intensive lifestyle intervention - strict diet and exercise, with follow-up - can reduce the risk of developing diabetes by 58%, and by up to 71% for people over 60 (2). These results suggest that intensive lifestyle intervention may be more effective than pharmacological treatment in preventing diabetes and thus accelerated aging. © AGE Breaker, updated 10 2024 [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] More on https://swll.to/H7SpQJ #agebreaker #glycation #antiaging #longevitymedicine #preventivemedicine #preventivehealth #skinaging #4pmedicine #advancedglycationendproducts (1): HOSTALEK, Ulrike et CAMPBELL, Ian. Metformin for diabetes prevention: update of the evidence base. Current medical research and opinion, 2021, vol. 37, no 10, p. 1705-1717. DOI:10.1080/03007995.2021.1955667 (2): https://swll.to/vphCuBw. Last update 10 2024