SkillCell

Last Friday, 22 November, Victor PETIT represented SkillCell at the AFVAC : Association Française des Vétérinaires pour Animaux de Compagnie congress in Lyon, accompanied by Yann LAGADIC, Azapharm's specialist in animal health. They engaged with the veterinary community to discuss critical challenges in diagnostics and animal wellbeing. Our innovative Programmable Non-Living Biomachines (PNLB) technology was at the heart of the discussions, offering promising solutions to advance veterinary practice. We are driving the future of animal diagnostics and wellness. Stay tuned for more exciting developments in animal health! #AnimalHealth #OneHealth #VeterinaryInnovation #SyntheticBiology #SynBioThursday

Research in The Lancet highlights the urgent need for earlier intervention in gestational diabetes. A recent series of papers calls for a paradigm shift in how we approach this increasingly common condition, impacting one in seven pregnancies worldwide. The research makes several key recommendations: ⭐ Earlier Screening: Instead of waiting until 24-28 weeks, experts suggest screening for gestational diabetes between 10-14 weeks of pregnancy, with a second screening at the standard 24-28 weeks. This two-step approach would help identify cases that develop earlier or later in pregnancy. ⭐ Global Standardization of Testing: The series advocates uniform testing methods worldwide. Currently, variations in screening and diagnostic practices make comparing data and tracking trends difficult, potentially leading to missed diagnoses. A universal fasting 75g oral glucose tolerance test (OGTT), administered twice during pregnancy, is recommended to balance accuracy with patient comfort. ⭐ Gestational Diabetes as a "Life Course" Disease: The research proposes a fundamental shift in perspective, viewing gestational diabetes not as a temporary pregnancy complication, but as a condition with long-term health consequences for both mother and child. This "life course" approach emphasizes the need for ongoing monitoring and management beyond pregnancy. These changes could significantly impact the detection and management of gestational diabetes, a condition linked to serious complications such as preeclampsia, stillbirth, and an increased risk of type 2 diabetes for both mothers and their children. Read more in the article below from Annalisa Merelli for STAT #GestationalDiabetes #MaternalHealth #WomensHealth #DiabetesTuesday

Today is World Diabetes Day and it’s a good opportunity for us to dive deeper into what Insulin Resistance(IR) is and what its impact is on metabolic health. An article published in Frontiers in Science Endocrinology magazine provides a comprehensive overview of IR, examining its causes, mechanisms, and treatment strategies. IR is a significant risk factor in the development of numerous chronic diseases, including diabetes, cardiovascular disease, cancer, and NAFLD. The global prevalence of IR and metabolic syndrome is alarmingly high, impacting a significant portion of the world's population (estimated 25%). The article highlights the complex pathogenesis of IR, emphasizing its multifaceted nature and the interplay of various factors: Genetic predisposition, obesity, age, and underlying diseases all contribute to the development of IR. At a molecular level, any disruption to the insulin signaling pathway can lead to IR. This includes abnormalities in insulin receptor binding, disturbances in the internal environment (inflammation, hypoxia, lipotoxicity, and immune dysfunction), and impaired metabolic function of the liver and other organs. Current screening methods include a multitude of usually invasive tests focused on Glucose. Some of these tests are simpler (e.g simple blood test to test fasting glucose in the blood) and other more complex requiring more time or steps (e.g Oral Glucose Tolerance Test which involves multiple blood draws). We believe that given the impact and prevalence of IR, a rapid non-invasive diagnostic tool will allow many more people to get screened and detect IR early to prevent complications and comorbidities. This is why we developed our IDIR technology to rapidly detect & measure BCAAs in urine, allowing us to determine insulin resistance status accurately. Read more about Insulin Resistance in the article here: https://lnkd.in/eH7yvDVY. #InsulinResistance #WorldDiabetesDay #MetabolicHealth

An upcoming webinar from Genetic Engineering & Biotechnology News magazine will discuss the challenges of scaling up adeno-associated viral (AAV) gene therapies. We’re excited to tune in and explore how synthetic biology and artificial intelligence can be used to enhance the safety, efficacy, and production of these therapies. Specifically, the webinar, led by Mark Stockdale, Senior Director of strategic alliances at Asimov , will discuss the development of tissue-specific promoters, sequence optimization to boost gene expression, strategies to reduce cellular stress during production, and a platform for end-to-end optimization of gene therapies. Asimov’s clonal HEK293 cell line, optimized two-plasmid system, and model-driven process development are highlighted as key components of this platform. If you too are enthusiastic about Synbio, we feel that it can demonstrate the power of synthetic biology and what it can do or be used for. More details and registration in the link below 👇 #SynBioThursday #SyntheticBiology #Bioengineering

November 3 is global One Health day 🌍. One Health is an integrated, unifying approach, supported by the World Health Organization, that aims to sustainably balance and optimize the health of people, animals and ecosystems. It recognizes that the health of humans, domestic and wild animals, plants, and the wider environment (including ecosystems) are closely linked and interdependent 🔗. Read more on the WHO website: https://lnkd.in/egWcbuWK Or in the infographic below (in French) from Ministère de la Santé . #OneHealth #HealthInnovation #PublicHealth #OneHealthDay

Our deputy CEO Victor PETIT will be presenting SkillCell today at the #Biorezo event in Montpellier. Victor will be joined by Franck Molina who will speak about how we continue to innovate medical diagnostics. If you're in Montpellier, join us at 16:30 CET. More details about the event here: https://lnkd.in/d2gG7XRc #MedicalDiagnostics #HealthcareInnovation #Diagnostics

Our project manager and senior scientist VAN Thi Nhu Ngoc is in Switzerland this week for the non-coding RNA in brain development, function and evolution conference, organized by ETH Zürich. Together with colleague Marc Van Der Hofstadt Serrano, PhD from sys2Diag, she presented a poster yesterday about the "Assessment of #Salivary #MicroRNA by RT-qPCR: Challenges in data interpretation for #ClinicalDiagnosis. If you're in Ascona this week, and interested in learning more, reach out to VAN Thi Nhu Ngoc to meet! #Diagnostics #noninvasive

 🐾 𝗣𝗲𝘁 𝗪𝗲𝗹𝗹𝗻𝗲𝘀𝘀 𝗶𝘀 𝗕𝗼𝗼𝗺𝗶𝗻𝗴 𝗶𝗻 𝗘𝘂𝗿𝗼𝗽𝗲 Pet humanization is driving growth in the European pet wellness market, as owners increasingly focus on their pets’ holistic well-being, including physical, emotional, and mental health. This trend presents exciting opportunities for pet care brands to innovate and cater to the evolving needs of pet parents. Here are some key insights from @Euromonitor International: • 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗽𝗲𝘁 𝗳𝗼𝗼𝗱 𝗮𝗻𝗱 𝘁𝗿𝗲𝗮𝘁𝘀 𝗮𝗿𝗲 𝗼𝗻 𝘁𝗵𝗲 𝗿𝗶𝘀𝗲, with owners seeking products that offer specific benefits like digestive health, mobility support, and immune system health. • 𝗧𝗵𝗲 𝗴𝗹𝗼𝗯𝗮𝗹 𝗽𝗲𝘁 𝗱𝗶𝗲𝘁𝗮𝗿𝘆 𝘀𝘂𝗽𝗽𝗹𝗲𝗺𝗲𝗻𝘁𝘀 𝗺𝗮𝗿𝗸𝗲𝘁 𝗿𝗲𝗮𝗰𝗵𝗲𝗱 𝗨𝗦𝗗 𝟮.𝟭 𝗯𝗶𝗹𝗹𝗶𝗼𝗻 𝗶𝗻 𝟮𝟬𝟮𝟯, 𝗴𝗿𝗼𝘄𝗶𝗻𝗴 𝗮𝘁 𝗮 𝟵% 𝗖𝗔𝗚𝗥 𝗳𝗿𝗼𝗺 𝟮𝟬𝟭𝟴-𝟮𝟬𝟮𝟯. This indicates a shift towards proactive pet health management. • 𝗣𝗲𝘁 𝗼𝘄𝗻𝗲𝗿𝘀 𝗮𝗿𝗲 𝗮𝗹𝘀𝗼 𝗽𝗿𝗶𝗼𝗿𝗶𝘁𝗶𝘇𝗶𝗻𝗴 𝘁𝗵𝗲𝗶𝗿 𝗽𝗲𝘁𝘀' 𝗲𝗺𝗼𝘁𝗶𝗼𝗻𝗮𝗹 𝗮𝗻𝗱 𝗺𝗲𝗻𝘁𝗮𝗹 𝘄𝗲𝗹𝗹-𝗯𝗲𝗶𝗻𝗴, creating a demand for products that address stress, anxiety, and relaxation. • 𝗕𝗿𝗮𝗻𝗱𝘀 𝗮𝗿𝗲 𝗶𝗻𝗰𝗼𝗿𝗽𝗼𝗿𝗮𝘁𝗶𝗻𝗴 𝗽𝗹𝗮𝘆 into their products to enhance pet engagement and well-being. Read the full report below: #PetWellnessMonth #AnimalHealth #OneHealth

A recent study published in The Lancet Diabetes and Endocrinology reveals that early pregnancy HbA1c testing can significantly predict gestational diabetes (GD), potentially streamlining the screening process and reducing reliance on complex oral glucose tolerance tests (OGTT). This is particularly important for low- and middle-income countries where access to comprehensive testing is limited. The current standard for diagnosing gestational diabetes, an oral glucose tolerance test (OGTT), presents several challenges, including difficulty in administration, analytical errors, and poor reproducibility. These issues often result in low screening rates, even in high-income countries. The study also found that combining HbA1c results with other risk factors like age, BMI, and family history of diabetes, offers a powerful predictive tool. Thanks to this breakthrough there is room for revolutionizing gestational diabetes screening, particularly in low-resource settings. By using a simple, accessible test like HbA1c, healthcare providers can identify at-risk women early and implement appropriate interventions to improve both maternal and fetal health outcomes. At SkillCell we went further in simplifying insulin resistance diagnostics. Our #IDIR test, which measures BCAAs in urine, allows us to determine metabolic status accurately with one simple, rapid and non-invasive test. Read more in the article below from News Medical, or access the full study here: https://lnkd.in/e5KQ9zqe #DiabetesTuesday #GestationalDiabetes #EarlyDisagnosis

It's Pet Wellness Month and that is a great opportunity to talk about animal health! 🐶 A recent article by Ester Banque, EVP and president of U.S. Operations for Zoetis for Fast Company explores the fascinating intersection between animal health care and human medicine. She  shares some insights from both her personal life and professional career that highlight this intersection. 🐾 Cross-Species Innovations: Many advancements in veterinary medicine, like advanced imaging and telemedicine, are being adapted for human health care. This collaboration fosters a more integrated approach to overall health. 🐾 Data-Driven Decisions: The rise of big data in veterinary practices is enhancing animal care and informing human medical practices, especially in predictive analytics for disease outbreaks. 🐾 Veterinary Vaccines: The development of animal vaccines has significantly influenced breakthroughs in human vaccines. For instance, the rapid development of COVID-19 vaccines drew from prior research in veterinary medicine, showcasing the interconnectedness of both fields. 🐾 Telehealth Expansion: The pandemic accelerated the adoption of telehealth services across both sectors, improving accessibility and setting a new standard for future health care models. 🐾 Economic Impact: The global animal health market is projected to reach $70 billion by 2025! This growth not only highlights the importance of animal health but also its role in enhancing human health through improved food safety and disease prevention. Read more in the article below. #AnimalHealth #OneHealth #VeterinaryMedicine #PetWellnessMonth