50 Cent does another collaboration with another deceased legend as 50 Cent had previously did a song with The Notorious B.I.G. in their song “Niggas aka Realest Niggas” which the title of this song can be seen as a the next installment of that track. This time 50 Cent collabs with 2Pac and 50 Cent uses this opportunity to diss his arch rival Ja Rule who’s constantly been criticized for trying to imitate and be like 2Pac so 50 Cent figures that it’s only fitting for him to mock Ja Rule for this while he’s on a song with 2Pac.

In March 2003, MTV News reported that Miami producer Red Spyda, who made the beat, recalled how this song came together

We was in [the studio] in Miami and 50 was eating chicken. He heard the beat [and] when he heard Tupac’s part, he dropped his fork and was like, ‘Is the mic on?’ and went right in.

In April 2003, 2Pac’s Outlaw Immortalz group member Hussein Fatal told MTVNews that he was affronted when 50 Cent used 2Pac’s vocals on this song

I feel it’s a problem, playing with his lyrics like that, that needs to be addressed. I remember I heard it [and] they [were] trying to say that [Ja] is trying to sound like Pac when [50 is] dead on him. All you did was take “Ambitionz Az A Ridah” and play it back, wrote a verse and took it to the lab and said ‘I'mma be Pac now’ and just try to say all this bullshit about Rule. I’m one of the Outlawz, so my opinion is going to be real critical