SiriusXT

SiriusXT, a UCD spin-out, was set up by Paul Sheridan, Kenneth Fahy, Fergal O'Reilly and Tony McEnroe, with the intention of ‘revolutionising cell and tissue imaging’ via a lab-based soft x-ray microscope. “SiriusXT envisions a healthier world driven by innovation,” said McEnroe, who is the company Managing Director. “We strive to contribute to global health efforts by making soft x-ray microscopy accessible, accelerating the understanding, detection and prevention of diseases.” Explaining the process of creating SiriusXT’s technology, McEnroe said the spectroscopy group at UCD focused on developing high-brightness light sources, in the extreme ultraviolet (EUV) spectrum. It achieved this by using a technique called “laser-produced plasma”. While the target market for this technology was in semiconductor lithography, the founders of SiriusXT agreed that there was potential for adapting this technology in order develop low-energy x-ray sources for application in cell and tissue imaging. The company first introduced its SXT-100 soft x-ray microscope to the market in 2023 with the installation of a microscope in the UCD Conway Institute. “We have spent the past two years conducting trials with over 30 target customers and we are forecasting first commercial orders for the microscope in 2025. We have built a team of highly skilled physicists, biologists as well as mechanical, electronic and software engineers. This team has not only developed the microscope but also works with targeted end users to develop novel imaging workflows for disease research and drug discovery applications.” “Our goal is to build a globally successful business that empowers scientific discovery by providing high-resolution soft x-ray imaging tools that reveal the full structure of intact biological cells,” explained McEnroe. “In so doing, we aim to advance scientific insights and accelerate progress in nanomedicine and biological research.” via Ciarán Mather and Silicon Republic. UCD Research Knowledge Transfer Ireland (KTI) TechIreland

University College Dublin spin-out SiriusXT was set up with the intention of ‘revolutionising cell and tissue imaging’ via a lab-based soft x-ray microscope. https://vist.ly/3msw38i

❗𝐌&𝐌 2025 𝐜𝐚𝐥𝐥 𝐟𝐨𝐫 𝐩𝐚𝐩𝐞𝐫𝐬 𝐧𝐨𝐰 𝐎𝐏𝐄𝐍❗ 🌟We are excited to announce our co-organised symposium B02 – “Biological Soft X-ray Tomography” at M&M 2025!🌟 🔬This symposium is a forum for the exchange of information and knowledge on the latest advances in soft X-ray tomography instrumentation methods for imaging biological specimens.    🔬Soft X-ray tomography (SXT) is a powerful label-free technology for quantitative and unbiased ultrastructural imaging of whole fully hydrated cell and tissue samples. SXT can be correlated with Fluorescence microscopy to provide detailed structural and functional information about biological samples. Correlation with Electron microscopy allows researchers to first acquire soft X-ray images to visualize large-scale structures or to identify specific regions of interest, followed by electron microscopy for ultra-high-resolution imaging of those areas. This combined approach can give a more comprehensive understanding of the sample's structure, composition, and function.    🔬Invited papers will demonstrate the diverse applications of SXT in the biosciences and the technical advances in specimen preparation, data processing and reconstruction, and imaging formation theory that made them possible. Target audience will include cell biologists, and scientists and engineers interested in novel microscopies, including correlative cryo light and structural cell imaging methods. 𝐓𝐨𝐩𝐢𝐜𝐬: 🔺Soft X-ray microscope instrumentation and biological applications 🔺Software for data processing and calculating tomographic reconstructions 🔺Modelling image formation in a soft X-ray microscope 🔺Specimen handling and cryo-preservation 🔺Correlation of soft X-ray tomography data with information from other modalities 🎙️𝐈𝐧𝐯𝐢𝐭𝐞𝐝 𝐬𝐩𝐞𝐚𝐤𝐞𝐫𝐬: Dr. Michele Darrow, The Rosalind Franklin Institute, UK. Dr. Venera Weinhardt, Heidelberg University, Germany. Dr. Kate White, University of Southern California, USA. 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐨𝐫𝐠𝐚𝐧𝐢𝐬𝐞𝐫𝐬: Prof. Carolyn Larabell, University of California, San Francisco. Dr. Kenneth Fahy, SiriusXT. Join us at M&M 2025 to explore the innovative world of biological soft X-ray tomography!😀 𝐂𝐡𝐞𝐜𝐤 𝐨𝐮𝐭 𝐭𝐡𝐞 𝐌&𝐌 𝐰𝐞𝐛𝐬𝐢𝐭𝐞 𝐟𝐨𝐫 𝐦𝐨𝐫𝐞 𝐢𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝐩𝐚𝐩𝐞𝐫 𝐬𝐮𝐛𝐦𝐢𝐬𝐬𝐢𝐨𝐧𝐬 ➡️ https://lnkd.in/e3gxsA2f ‼️𝐃𝐞𝐚𝐝𝐥𝐢𝐧𝐞 14𝐭𝐡 𝐅𝐞𝐛𝐫𝐮𝐚𝐫𝐲‼️ #conference #Microscopy #Networking #Research #Science #STEM #Imaging #Biotech #SXT #SXT #SiriusXT #UCSF #USA #Innovation #Collaboration #Biopharma #DrugDiscovery #LifeSciences #Biology #PHD #Student #Researcher #Presentation

Soft X-ray Tomography helps in enabling a Science Magazine 'breakthrough of 2024'. https://lnkd.in/eR63WcVW #SXT #cryoSXT #nanoCT #TableTopTomography

🔬Cryo-soft X-ray microscopy: establishing the foundation for cryo-correlative imaging workflows🔬 🔹Dr Sergey Kapishnikov, Director of Imaging Applications at SiriusXT, presented at the Microscopy Society of Ireland yesterday, detailing the benefits of incorporating Soft X-ray Tomography (SXT) into correlative workflows. 🔹Sergey’s talk entitled “Cryo-soft X-ray microscopy: establishing the foundation for cryo-correlative imaging workflows” outlined how SiriusXT’s lab-scale microscope (the SXT-100) can be integrated with fluorescence and electron microscopy to increase imaging throughput, as well to provide additional context on the volume being imaged. 🔹The SXT-100 has the unique capability to non-destructively image the 3D subcellular and intercellular organisation of hydrated cellular samples in their native state with minimal sample preparation to nanometre resolution. It is extremely beneficial as a standalone imaging technique, or when used as part of a correlative workflow! ⭐𝐓𝐨 𝐥𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐨𝐮𝐫 𝐒𝐗𝐓-100, 𝐥𝐚𝐛-𝐛𝐚𝐬𝐞𝐝 𝐬𝐨𝐟𝐭 𝐱-𝐫𝐚𝐲 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐞, 𝐯𝐢𝐬𝐢𝐭 👉 https://lnkd.in/eg_trP94 ⭐𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐚 𝐝𝐞𝐦𝐨 𝐚𝐭 👉 info@siriusxt.com #SiriusXT #SXT #MSI #MSI2025 #UCD #Microscopy #Biology #Laboratory #Imaging #Microscope #Technology #Innovation #Research #Science #LifeSciences #Conference #Networking #Biotech

Dr Dimitri Scholz, Director of Biological Imaging at University College Dublin, presented at the Microscopy Society of Ireland today, explaining how Soft X-ray Tomography (SXT) fits into his future cryo-imaging workflows🔬 🌟Incorporating SXT into correlative imaging workflows alongside other imaging modalities can increase imaging throughput, provide additional context on the volume being imaged as well improve the accuracy with which regions of interest in the cell volume can be targeted! 🌟𝐓𝐨 𝐥𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐭𝐡𝐞 𝐯𝐚𝐫𝐢𝐨𝐮𝐬 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐒𝐗𝐓, 𝐯𝐢𝐬𝐢𝐭 𝐨𝐮𝐫 𝐢𝐦𝐚𝐠𝐞 𝐠𝐚𝐥𝐥𝐞𝐫𝐲 https://lnkd.in/e5GAq4zr 📧𝐂𝐨𝐧𝐭𝐚𝐜𝐭 𝐒𝐢𝐫𝐢𝐮𝐬𝐗𝐓 𝐭𝐨 𝐫𝐞𝐪𝐮𝐞𝐬𝐭 𝐚 𝐝𝐞𝐦𝐨 ➡️ info@siriusxt.com #SXT #SiriusXT #MSI #MSI2025 #UCD #Science #Microscopy #Laboratory #Innovation #Conference #Dublin #STEM #Imaging #Research

🎉SiriusXT kicks off 2025 by presenting at the Microscopy Society of Ireland!🎉 🔬Soft X-ray tomography (SXT) is a powerful standalone imaging technique, with the unique ability to image the subcellular structure of whole hydrated cells as well as to track the delivery of nanoparticles, carrying therapeutics and vaccines to targeted sites within cells! 🔬SXT can also be integrated into correlative imaging workflows alongside other imaging modalities, such as Fluorescence Microscopy (FM) and Electron Microscopy (EM) to increase imaging throughput, provide additional context on the volume being imaged and to improve the accuracy with which regions of interest in the cell volume can be targeted! ⭐𝐃𝐫 𝐒𝐞𝐫𝐠𝐞𝐲 𝐊𝐚𝐩𝐢𝐬𝐡𝐧𝐢𝐤𝐨𝐯’𝐬 presentation will focus on the topic of “𝐂𝐫𝐲𝐨-𝐬𝐨𝐟𝐭 𝐗-𝐫𝐚𝐲 𝐦𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲: 𝐞𝐬𝐭𝐚𝐛𝐥𝐢𝐬𝐡𝐢𝐧𝐠 𝐭𝐡𝐞 𝐟𝐨𝐮𝐧𝐝𝐚𝐭𝐢𝐨𝐧 𝐟𝐨𝐫 𝐜𝐫𝐲𝐨-𝐜𝐨𝐫𝐫𝐞𝐥𝐚𝐭𝐢𝐯𝐞 𝐢𝐦𝐚𝐠𝐢𝐧𝐠 𝐰𝐨𝐫𝐤𝐟𝐥𝐨𝐰𝐬”, at the 𝐌𝐢𝐜𝐫𝐨𝐬𝐜𝐨𝐩𝐲 𝐒𝐨𝐜𝐢𝐞𝐭𝐲 𝐨𝐟 𝐈𝐫𝐞𝐥𝐚𝐧𝐝 conference being held at University College Dublin. Sergey's talk will take place at 15:50𝐩𝐦 𝐭𝐨𝐦𝐨𝐫𝐫𝐨𝐰, 𝐉𝐚𝐧𝐮𝐚𝐫𝐲 14𝐭𝐡, 𝐢𝐧 𝐭𝐡𝐞 𝐎’𝐁𝐫𝐢𝐞𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐂𝐞𝐧𝐭𝐫𝐞 𝐚𝐭 𝐔𝐂𝐃. 🙂𝐂𝐨𝐦𝐞 𝐚𝐭𝐭𝐞𝐧𝐝 𝐨𝐮𝐫 𝐩𝐫𝐞𝐬𝐞𝐧𝐭𝐚𝐭𝐢𝐨𝐧 𝐚𝐭 𝐌𝐒𝐈 2025 or … 🔗𝐂𝐡𝐞𝐜𝐤 𝐨𝐮𝐭 𝐨𝐮𝐫 𝐢𝐦𝐚𝐠𝐞 𝐠𝐚𝐥𝐥𝐞𝐫𝐲 𝐭𝐨 𝐥𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐭𝐡𝐞 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐒𝐗𝐓➡️ https://lnkd.in/e5GAq4zr To learn more about the event with Microscopy Society of Ireland, visit ➡️ https://lnkd.in/dKhaGwSt #Microscopy #SXT #EM #FM #vEM #Conference #Presentation #Imaging #LifeSciences #Research #LifeSciences #Biology #Science #Innovation #Laboratory #Nanoparticles #Workflow #UCD #SiriusXT #MSI #MSI2025

SiriusXT’s SXT-100 Makes a Big Splash in 2024! This year marked a pivotal moment for lab-based soft X-ray tomography! Research work, conducted with SiriusXT’s SXT-100 microscope, in collaboration with 13 partner organizations across 8 countries, featured prominently in 15 scientific publications and was showcased at 13 international conferences. We extend our heartfelt thanks to our collaborators at: - Universities: Aalen, Heidelberg, Jyväskylä, King’s College London, Nottingham, Southern Denmark, UCL, UCD, and Waterford. - Research Institutes: Pasteur, Czech Academy of Science, Spanish National Research Council, and Tescan. Together, we’re pushing the boundaries of cellular imaging and advancing scientific discovery. We look forward to extending our collaborations in 2025. ⭐𝐒𝐨𝐟𝐭 𝐱-𝐫𝐚𝐲 𝐭𝐨𝐦𝐨𝐠𝐫𝐚𝐩𝐡𝐲’𝐬 𝐮𝐧𝐢𝐪𝐮𝐞 𝐜𝐚𝐩𝐚𝐛𝐢𝐥𝐢𝐭𝐢𝐞𝐬 𝐡𝐚𝐯𝐞 𝐰𝐢𝐝𝐞 𝐫𝐚𝐧𝐠𝐢𝐧𝐠 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬, 𝐯𝐢𝐞𝐰 𝐨𝐮𝐫 𝐢𝐦𝐚𝐠𝐞 𝐠𝐚𝐥𝐥𝐞𝐫𝐲 𝐭𝐨 𝐯𝐢𝐞𝐰 𝐦𝐨𝐫𝐞 ➡️ https://lnkd.in/e5GAq4zr ⭐𝐆𝐞𝐭 𝐢𝐧 𝐭𝐨𝐮𝐜𝐡 𝐭𝐨 𝐫𝐞𝐪𝐮𝐞𝐬𝐭 𝐚 𝐝𝐞𝐦𝐨 ➡️ info@siriusxt.com

⭐It’s been a remarkable year for SiriusXT, and 2025 is shaping up to look even more exciting!⭐ 🌏We have had the opportunity to demonstrate the capabilities of our lab-based soft x-ray microscope, the SXT-100, to organisations all over the world. From Switzerland, to America, to Germany and many other countries in between, it has been a pleasure to share lab-based soft x-ray tomography with so many curious minds and to meet so many wonderful people in the process!🔬 🤝We have had the pleasure of working on numerous fascinating research projects with our enthusiastic collaborators, helping them increase their understanding in the fields of disease and drug research! We have loved sharing snippets of this work with you online!😊 🎄So as we wind down for the holidays at SiriusXT, we want to wish you all a very Merry Christmas and a Happy New Year and we look forward to engaging with you again in 2025! 🎉🎅 #SXT #SiriusXT #Microscopy #Collaboration #Science #Research #HappyChristmas #Christmas #NewYear #HappyHolidays

Soft X-Ray Microscopy reveals prion-induced changes in cell and organelle morphology that help scientists understand the action of deadly prion diseases! 🔬SiriusXT presented a poster at the #CellBio conference in San Diego this week entitled “Near-native imaging of prion spread and associated changes in primary neurons using cryogenic electron and soft X-ray tomography guided by fluorescence”. The poster was based on research carried out by Szymon W. Manka from Imperial College London, that used SiriusXT’s SXT-100 soft X-ray microscope. 🔬A prion is a type of protein that can trigger normal proteins in the brain to fold abnormally, leading to brain damage. Prion diseases are fatal and can affect both humans and animals. Bovine spongiform encephalopathy (‘BSE’, also known as ‘mad cow disease’) and its human-equivalent, Creutzfeldt-Jakob disease (‘CJD’), are examples of prion diseases. 🔬Szymon’s research aims to understand how prions enter, grow and spread among brain cells. He uses leading-edge correlative imaging workflows that combine fluorescent light, electron, and soft X-ray microscopy (#CLEXM) to facilitate his research. 🔬The large field of view and high native contrast of the #SiriusXT SXT-100 soft X-ray microscopy facilitates quantitative comparisons in changes to cell and organelle morphology and distribution in response to prion infection. ⭐𝐒𝐨𝐟𝐭 𝐱-𝐫𝐚𝐲 𝐭𝐨𝐦𝐨𝐠𝐫𝐚𝐩𝐡𝐲’𝐬 𝐮𝐧𝐢𝐪𝐮𝐞 𝐜𝐚𝐩𝐚𝐛𝐢𝐥𝐢𝐭𝐢𝐞𝐬 𝐡𝐚𝐯𝐞 𝐰𝐢𝐝𝐞 𝐫𝐚𝐧𝐠𝐢𝐧𝐠 𝐚𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬, 𝐯𝐢𝐞𝐰 𝐨𝐮𝐫 𝐢𝐦𝐚𝐠𝐞 𝐠𝐚𝐥𝐥𝐞𝐫𝐲 𝐭𝐨 𝐯𝐢𝐞𝐰 𝐦𝐨𝐫𝐞 ➡️ https://lnkd.in/e5GAq4zr ⭐𝐆𝐞𝐭 𝐢𝐧 𝐭𝐨𝐮𝐜𝐡 𝐭𝐨 𝐫𝐞𝐪𝐮𝐞𝐬𝐭 𝐚 𝐝𝐞𝐦𝐨 ➡️ info@siriusxt.com #CellBio2024 #SiriusXT #SanDiego #Science #Research #Microscopy #Innovation #Collaboration #Networking #STEM #Conference #Poster American Society for Cell Biology (ASCB)