[en] Inclusive electron scattering measured in the kinematic range of Bjorken x>1 and high momentum transfers can provide important information on reaction mechanisms through the study of scaling violations, and can provide insight on the transition from deep inelastic scattering from quarks to quasielastic scattering from nucleons. Some preliminary results from Jefferson Lab Experiment E89-008 will be presented as well as the increased kinematic range expected for the approved E89-008 Extension with a 6 GeV beam. The increased scope for physics studies with a 12 GeV beam and improved Hall C instrumentation are then discussed

[en] This report presents analytical solutions of the dissolution and hydrogeologic transport of radionuclides in geologic repositories. Numerical examples are presented to demonstrate the equations resulting from these analyses. The subjects treated in this report are: solubility-limited transport with transverse dispersion (chapter 2); transport of a radionuclide chain with nonequilibrium chemical reactions (chapter 3); advective transport in a two-dimensional flow field (chapter 4); radionuclide transport in fractured media (chapter 5); a mathematical model for EPA's analysis of generic repositories (chapter 6); and dissolution of radionuclides from solid waste (chapter 7). Volume 2 contains chapters 5, 6, and 7

[en] The effect of partial substitution of Ca by Y, Er and Lu on the structural transport properties of (Bi_l.6Pb_0.4)(Sr_l.8Ba_0.2)(Ca_1-xR_x)₂Cu₃O_y, superconductors ceramics (0<=x<= 0.03) have been investigated. The substitution of Y, Lu and Er at the Ca site induced the decrease of the volume fraction for the '2223' phase and the increase of the '2212' and '2201' phases volume fractions. In the normal state, all the samples are characterized by a linear temperature dependence of electrical resistivity and Hall concentrations. The rate of depression for the critical temperature in x=0.02 samples found to be nearly the same for all of these substitutions. The sample shows a linear dependence of intergranular temperature as a function of ac-field amplitude, which is in agreement with the Mueller critical state model. (authors)

[en] This report presents analytical solutions of the dissolution and hydrogeologic transport of radionuclides in geologic repositories. Numerical examples are presented to demonstrate the equations resulting from these analyses. The subjects treated in this present report are: Solubility-limited transport with transverse dispersion (Chapter 2); Transport of a radionuclide chain with nonequilibrium chemical reactions (Chapter 3); Advective transport in a two-dimensional flow field (Chapter 4); Radionuclide transport in fractured media (Chapter 5); A mathematical model for EPA's analysis of generic repositories (Chapter 6); and Dissolution of radionuclides from solid waste (Chapter 7)

[en] There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer, immune checkpoint inhibitors also appear to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design

[en] We propose to measure pion electroproduction off ¹H, ², ¹²C, ⁶⁴Cu, and ¹⁹⁷Au, and extract the pion transparency through the nuclear medium between Q² = 1 and 5 (GeV/c)². The pion transparency is predicted to be a signature of the onset of nuclear filtering and/or Color Transparency. Recent experiments have reported evidence for Color Transparency effects at Q² approx 10 (GeV/c)². The occurrence of nuclear filtering could potentially explain the apparent discrepancy between (proton) nuclear transparencies found in quasielastic A(e,e'p) and A(p,2p) experiments. The occurrence of these effects is an effective signature of the approach to the factorization regime in meson electroproduction experiments, necessary for the access to Generalized Parton Distributions. Measurable effects of approx. 40% are predicted for this region of Q². The proposed experiment seeks to measure the pion transparency with 5-10% uncertainties, dominated by systematics, up to Q² = 5 (GeV/c)²

[en] We report the results of a new Rosenbluth measurement of the proton form factors at Q² values of 2.64, 3.20 and 4.10 GeV². Cross sections were determined by detecting the recoiling proton in contrast to previous measurements in which the scattered electron was detected. At each Q², relative cross sections were determined to better than 1%. The measurement focused on the extraction of G_E/G_M which was determined to 4-8% and found to approximate form factor scaling, i.e. μ_pG_E ∼ G_M. These results are consistent with and much more precise than previous Rosenbluth extractions. However, they are inconsistent with recent polarization transfer measurements of comparable precision, implying a systematic difference between the two techniques

[en] Tensor polarization observables (t20, t21 and t22) have been measured in elastic electron-deuteron scattering for six values of momentum transfer between 0.66 and 1.7 (GeV/c) 2. The experiment was performed at the Jefferson Laboratory in Hall C using the electron HMS Spectrometer, a specially designed deuteron magnetic channel and the recoil deuteron polarimeter POLDER. The new data determine to much larger Q 2 the deuteron charge form factors GC and GQ. They are in good agreement with relativistic calculations and disagree with pQCD predictions

[en] The ¹H(e,e(prime)π⁺)n cross section was measured for a range of four-momentum transfer up to Q²=3.91 GeV² at values of the invariant mass, W, above the resonance region. The Q²-dependence of the longitudinal component is consistent with the Q²-scaling prediction for hard exclusive processes. This suggests that perturbative QCD concepts are applicable at rather low values of Q². Pion form factor results, while consistent with the Q²-scaling prediction, are inconsistent in magnitude with perturbative QCD calculations. The extraction of Generalized Parton Distributions from hard exclusive processes assumes the dominance of the longitudinal term. However, transverse contributions to the cross section are still significant at Q²=3.91 GeV²

[en] The A(Q²) structure function in elastic electron-deuteron scattering was measured at six momentum transfers Q² between 0.66 and 1.80 (GeV/c)² in Hall C at Jefferson Laboratory. The scattered electrons and recoil deuterons were detected in coincidence, at a fixed deuteron angle of 60.5^o. These new precise measurements resolve discrepancies between older sets of data. They put significant constraints on existing models of the deuteron electromagnetic structure, and on the strength of isoscalar meson exchange currents