[en] By using the path integral approach, we investigate the problem of Hooke's atom (two electrons interacting with Coulomb potential in an external harmonic-oscillator potential) in an arbitrary time-dependent electric field. For a certain infinite set of discrete oscillator frequencies, we obtain the analytical solutions. The ground state polarization of the atom is then calculated. The same result is also obtained through linear response theory. (general)

[en] Objective: To explore the features and value of ¹⁸F-NaF PET/CT bone scintigraphy in patients with hyperparathyroid bone disease. Methods: Thirty cases [11 men and 19 women, aged 18-71 (52.3 ± 13.5) years] were confirmed through clinical and postoperative pathology as hyperparathyroidism. All patients underwent ¹⁸F-NaF PET/CT and ⁹⁹Tc^m-methylenediphosphonate (⁹⁹Tc^m-MDP) whole-body bone scintigraphy, and the characteristics of the obtained ¹⁸F-NaF PET/CT bone images were retrospectively analyzed. Results of the detection rate of local bone disease were compared between the two types of bone scintigraphy, and brown tumors were evaluated according to Mirels' criteria. Results: The qualitative results of the two bone scintigraphy methods were identical. A total of 15 cases with negative bone scintigraphy and 15 cases with positive bone scintigraphy were analyzed. The osteopathy of hyperparathyroid bone disease on the ¹⁸F-NaF PET images was characterized by a variety of bone diseases that were mainly composed of diffuse bone metabolism in multiple bones throughout the body. When brown tumors, bone sclerosis, pathological fractures, and pseudofractures were concurrently present, they manifested as an abnormal distribution area of single or multiple focal imaging agents. Among the lesions found, brown tumors showed focal imaging agent concentration, imaging agent sparseness, or focal center imaging agent distribution defects with uneven imaging of the edge imaging agent. Fifteen cases of multiple forms of bone resorption, 13 cases of extensive osteoporosis, 7 cases of brown tumors, 6 cases of bone sclerosis, 3 cases of osteomalacia, and 3 cases of pathological fractures were observed. A total of 53 local bone lesions (i.e., brown tumors, bone sclerosis, pathological fractures, false fractures) were detected in 15 positive patients. All lesions were detected by ¹⁸F-NaF PET/CT bone scintigraphy, and only 32 lesions were detected by ⁹⁹Tc^m-MDP whole-body bone scintigraphy. Seven positive patients had long bone brown tumors with a total of 24 lesions, of which nine had a Mirels score greater than 9 points. Conclusions: Hyperparathyroid bone disease shows characteristic features related to bone metabolism and anatomy on ¹⁸F-NaF PET/CT bone scintigraphy, a technique that shows more lesions, as well as details of these lesions, than ⁹⁹Tc^m-MDP whole-body bone scintigraphy. Taken together, the results reveal that ¹⁸F-NaF PET/CT bone scintigraphy has important value in the diagnosis, differential diagnosis, and severity assessment of hyperparathyroid bone disease. (authors)

[en] Objective: To retrospectively evaluate the value of SPECT/CT imaging for follow-up of bone metastases. Methods: A total of 178 patients with bone metastases (387 lesions) underwent 2 or more events of whole-body bone scintigraphy (WBS) and SPECT/CT imaging. Sequential images were analyzed by 2 experienced, nuclear medicine physicians. Each lesion was interpreted as progressive, remissive or stable in WBS or SPECT/CT independently. Reasons for the discordance between WBS and SPECT/CT results were analyzed. The results of clinical follow-up, including clinical symptoms, tumor markers, serum ALP, radiograph, CT and MRI, were likewise classified as progressive, remissive or stable. The χ² test was used to compare the differences between the two imaging methods. Results: The follow-up results of the two imaging methods were consistent in 313 (80.88%, 313/387) lesions, including 208 in progression and 105 in remission or stable condition. Among the 74 (19.12%, 74/387) lesions showing discordance, 48 showed remission or stable conditions on WBS but progression on SPECT/CT (64.86%, 48/74); while 26 showed progression on WBS but remission or stable condition on SPECT/CT (35.14%, 26/74). There was a statistically significant difference of the follow-up results between WBS and SPECT/CT (χ²=6.54, P<0.05). Conclusion: SPECT/CT is more valuable than WBS for follow-up of bone metastases. (authors)

[en] Objective: To investigate the effect of edaravone treatment on plasma ET-1 and CGRP levels changes in patients with traumatic intracerebral hemorrhage. Methods: Plasma ET-1 and CGRP levels were measured with RIA in 40 patients with traumatic intracerebral hemorrhage both before and after treatment with 60mg of edaravone i. v. q. d. for 5 days, 40 patients both before and after treatment with conventional treatment only (without edaravone) and 30 controls (once only). Results: The plasma ET-1 levels were significantly increased in all the patients at admission than those in controls. After treatment, the levels in all the patients dropped significantly, but the levels were significantly lower in edaravone-treated patients than those in non-edaravone-treated patients (P<0.01). The reverse was true for plasma CGRP levels. Conclusion: Edaravone treatment could correct the abnormal plasma ET-1 and CGRP levels in patients with traumatic intracerebral hemorrhage and might be beneficial to recovery. (authors)

[en] To investigate the effect of naloxone on the changes of plasma ET-1 and CGRP levels in patients with traumatic brain injury, ninety patients with traumatic brain injury were randomly divided into naloxone treated group and conventionally treated group (both n=45). The plasma levels of ET-1 and CGRP in both groups before and after treatment and in 30 healthy controls were measured by RIA. The results showed that the plasma levels of ET-1 were significantly increased in the patient before treatment and decreased markedly after treatment in both groups. The magnitude of decrease of the plasma ET-1 levels in the naloxone treated group was significantly higher than that in the conventionally treated group (P<0.01). The plasma levels of CGRP were significantly decreased in the patients before treatment and increased markedly after treatment in both groups. The magnitude of increase of the plasma CGRP levels in the naloxone treated group was significantly higher than that in the conventionally treated group (P<0.01). The plasma ET-1 levels in patients with traumatic brain injury was remarkably increased and markedly decreased after treatment with naloxone. The plasma CGRP levels in patients with traumatic brain injury was remarkably decreased and markedly increased after treatment with naloxone. Naloxone has a favorable effect on patient with traumatic brain injury, it may protect the neural cells and improve their living quality. (authors)

[en] We revisit the superadditivity conjecture for skew information which has recently been disproved by Hansen (2007 J. Stat. Phys. 126 643). We establish two weak forms of superadditivity which are conjectured to be optimal. Our results show that in a certain sense the superadditivity is true with '50% off'

[en] Objective: To evaluate the clinical significance of abnormal soft tissue uptake of bone tracer. Methods: Thirty patients with abnormal soft tissue uptake of bone tracer on ⁹⁹Tc^m-methylene diphosphonic acid (MDP) skeletal imaging were analyzed. Radioactivity of soft tissue accumulated equal to or greater than the ribs were considered as abnormal. The result was compared with pathology, MRI, CT, X-ray, ultrasound, findings for evaluating its clinical significance. Results: In 7 patients with diffuse liver uptake of ⁹⁹Tc^m-MDP, 6 were massive and 1 nodular liver cancer. In 2 patients with local liver uptake, one was metastatic and the other primary liver cancer. In 5 local lung uptake cases 4 were primary lung cancer and one metastatic. In 5 cases with colonic uptake 1 was schistosomiasis while the other 4 unexplainable. Subcutaneous tissue uptake was observed in 4 patients, symmetrical uptake in 2 patients with metastatic calcification microfoci in multiple myeloma, unsymmetrical uptake in 2 patients with hemangioma and abscess. Pleural uptake in 3 patients all was metastatic cancer. Abdominal uptake in 3 patients was omentum, paravertebral soft tissue metastasis and unknown cause. Breast uptake in one patient was due to breast cancer. Conclusions: There are many causes resulting in abnormal nonosseous soft tissue uptake of ⁹⁹Tc^m-MDP. The final diagnosis should correlate with clinical data and other examinations. (authors)

[en] Objective: To evaluate the stability and biodistribution of a novel SPECT-MRI bi-functional agent ⁹⁹Tc^m-Gd-DTPA-DG in tumor-bearing nude mice. Methods: DTPA-DG was synthesized and then conjugated with Gd₂O₃ to generate Gd-DTPA-DG. The tumor-bearing nude mice were scanned by MRI to evaluate the tumor targeting ability of Gd-DTPA-DG. The orthogonal experiment was applied to optimize the synthesis condition of ⁹⁹Tc^m-Gd-DTPA-DG, such as Gd-DTPA-DG consumption, SnCl₂·2H₂O dosage, pH value of reaction medium and reaction temperature. The radiolabeling efficiency was measured by thin layer chromatography. The distribution of ⁹⁹Tc^m-Gd-DTPA-DG in nude mice was evaluated by scintigraphy in vivo. The % ID/g was measured at different time after intravenous injection of ⁹⁹Tc^m-Gd-DTPA-DG. Results: The tumor was significantly enhanced by Gd-DTPA-DG with MRI. The radiochemical purity of ⁹⁹Tc^m-Gd-DTPA-DG was about 98.5% and remained 96.2% at room temperature for 6 h. The tumor was well visualized by ⁹⁹Tc^m-Gd-DTPA-DG SPECT at 2 h after injection. The tumor uptake was (1.48±0.12) %ID/g, and the rumor to muscle radioactivity ratio was 2.91. Conclusions: MRI contrast of Gd-DTPA-DG may enhance tumor detection. ⁹⁹Tc^m-labeled Gd-DTPA-DG may be useful for tumor imaging and might have a potential role as a SPECT-MRI bi-functional agent. (authors)

[en] In this paper,the value of differentiating metastases from benign of bone lesions in patients with hepatocellular carcinoma using SPECT/ CT fusion imaging is evaluated. From patients with hepatocellular carcinoma (HCC) confirmed by pathology underwent bone scintigraphy, 97 patients were selected to undergo SPECT/CT scanning. The bone scintigraphy and SPECT/CT fusion images were analyzed by two experienced nuclear medicine physicians together. Each patient was rated using a 3-point diagnostic confidence scale: metastasis, benign and uncertainty. The analyzed items were divided into two groups, i.e. certainty to diagnose (metastasis and benign) and uncertainty to diagnose. The percentage and its 95% confidence intervals of each group were calculated. The coincidence rate of bone metastases compared with the final diagnosis and its 95% confidence interval were calculated. The degree of certainty to diagnose on bone scintigraphy was 36.1% (35/97), its 95% confidence intervals range from 26.5% to 45.6%. The degree of uncertainty to diagnose on bone scintigraphy was 63.9% (62/97), its 95% confidence intervals range from 54.4% to 73.5%. The coincidence rate of bone metastases was 50.0% (24/48), its 95% confidence intervals range from 35.9% to 64.1%. The degree of certainty to diagnose on SPECT/CT fusion images was 81.4% (79/97), its 95% confidence intervals range from 73.7 % to 89.1%. The degree of uncertainty to diagnose on SPECT/CT fusion images was 18.6% (18/97), its 95% confidence intervals range from 10.9% to 26.3%. The coincidence rate of bone metastases was 95.8% (46/48), its 95% confidence intervals range from 90.1% to 100%. SPECT/CT fusion images provide more information than bone scintigraphy in differentiating metastases from benign lesions in patients with HCC, increase the degree of certainty to diagnose, especially increase the diagnostic accuracy in some false-negative cases diagnosed by bone scintigraphy. (authors)

[en] The scale of modern airport continues to expand, considering the needs of future use of multiple aircraft types and models, in order to improve the relevant design and planning of taxiways in the current military airport, it is necessary to consider the structure of airport taxiways and Bridges. According to the experience of the civil airport taxi road and bridge construction, the paper analyzes the military airfield taxiing bridge structural characteristics and load characteristic, proposed for use in military airfield taxiing bridge structure form, the slide to the width of the bridge, span layout, section forms, high beam and the size, the details for the military airport taxi provides the reference for the simulation modeling and the analysis of internal force of bridge. (paper)