No abstract available

[en] A Talbot-Lau interferometer is a compact laboratory setup for phase-contrast imaging that can be used with a usual polychromatic X-ray source. Operating this setup with a broad spectrum is followed by a cutback in performance in comparison to monochromatic illumination. By evaluating the interferometer's complex energy-dependent response and using the information obtained by an energy-resolving detector, the performance might be increased again. Therefore, the energetic behaviour of the dark-field image was investigated. In simulations the energy dependence of the dark-field signal generated by small glass spheres was calculated and in order to verify these simulations, measurements using a Timepix detector were done. The results of the measurements show a good agreement with the simulations. In this contribution these results are presented, and the behaviour of the dark-field contrast is discussed.

No abstract available

[en] Purpose: X-ray dark-field imaging promises information on the small angle scattering properties even of large samples. However, the dark-field image is correlated with the object’s attenuation and phase-shift if a polychromatic x-ray spectrum is used. A method to remove part of these correlations is proposed. Methods: The experimental setup for image acquisition was modeled in a wave-field simulation to quantify the dark-field signals originating solely from a material’s attenuation and phase-shift. A calibration matrix was simulated for ICRU46 breast tissue. Using the simulated data, a dark-field image of a human mastectomy sample was corrected for the finger print of attenuation- and phase-image. Results: Comparing the simulated, attenuation-based dark-field values to a phantom measurement, a good agreement was found. Applying the proposed method to mammographic dark-field data, a reduction of the dark-field background and anatomical noise was achieved. The contrast between microcalcifications and their surrounding background was increased. Conclusions: The authors show that the influence of and dispersion can be quantified by simulation and, thus, measured image data can be corrected. The simulation allows to determine the corresponding dark-field artifacts for a wide range of setup parameters, like tube-voltage and filtration. The application of the proposed method to mammographic dark-field data shows an increase in contrast compared to the original image, which might simplify a further image-based diagnosis.

[en] X-ray dark-field imaging is a promising technique for lung diagnosis. Due to the alveolar structure of lung tissue, a higher contrast is obtained by the dark-field image compared to the attenuation image. Animal studies indicate an enhancement regarding the detection of lung diseases in early stages. In this publication, we focus on the influence of different Talbot–Lau interferometer specifications while maintaining the x-ray source, sample magnification and detector system. By imaging the same porcine lung with three different grating sets, we analyze the contrast-to-noise ratio of the obtained dark-field images with respect to visibility and correlation length. We demonstrate that relatively large grating periods of the phase and of the analyzer grating are sufficient for high quality lung imaging at reasonable dose levels. (paper)

[en] Talbot–Lau x-ray imaging provides additionally to the conventional attenuation image, two further images: the differential phase-contrast image which is especially sensitive to differences in refractive properties and the dark-field image which is showing the x-ray scattering properties of the object. Thus, in the dark-field image sub-pixeled object information can be observed. As it has been shown in recent studies, this is of special interest for lung imaging. Changes in the alveoli structure, which are in the size of one detector pixel, can be seen in the dark-field images. A fast acquisition process is crucial to avoid motion artifacts due to heartbeat and breathing of the patient. Using moiré imaging the images can be acquired with a single-shot exposure. Nevertheless, the spatial resolution is reduced compared to the phase-stepping acquisition. We evaluate the results of both imaging techniques towards their feasibility in clinical routine. Furthermore, we analyse the influence of artificial linear object movement on the image quality, in order to simulate the heartbeat of a patient. (paper)

No abstract available