[en] Highlights: • Liquefaction is promising approach for long distance H₂ storage and transportation. • Commercial H₂ liquefaction plants have specific energy consumption of 10–12.$\mathit{kWh}/{\mathit{kg}}_{{\mathit{LH}}_2}$. • Increased number of ortho-to-para converters increases the process complexity. • Mixed refrigerant cascaded process with only two catalytic converters is proposed. • Hydrogen is liquefied at the expense of 6.45 $\mathit{kWh}/{\mathit{kg}}_{{\mathit{LH}}_2}$with 47.2% exergy efficiency. To reduce CO₂ emissions and address climate change concerns, most futuristic studies investigating 100% renewable energy sources and subsequent power-to-gas/fuel/liquid/X technological developments have been based on hydrogen (H₂). The long-term storage and transportation of H₂ over long distances restrict its feasibility as an energy vector, mainly due to its low energy density. Liquefaction is a promising approach for overcoming these issues. However, it requires a large amount of energy, and if H₂ itself is used to provide this energy, then 25% to 35% of the initial quantity of H₂ is consumed. The existing H₂ liquefaction plants have specific energy consumption values in the range of 10–12 $\mathit{kWh}/{\mathit{kg}}_{{\mathit{LH}}_2}$ and exergy efficiencies in the range of 20%–30% with complicated configurations. Therefore, a thermodynamically efficient and compact design is required to facilitate a roadmap to H₂ economy. This paper proposes a simple, energy-efficient, and cost-effective process for H₂ liquefaction. Three refrigeration cycles with optimal mixed-refrigerant compositions are used, which makes the proposed process energy-efficient. Additionally, two-stage ortho-to-para conversion makes the process compact. The proposed process is unique in terms of its configuration and mixed-refrigerant combination. The modified coordinate descent approach was adopted to identify the optimal design variables for the proposed H₂ liquefaction process. The proposed process consumes an energy of 6.45 $\mathit{kWh}/{\mathit{kg}}_{{\mathit{LH}}_2}$, which is 36.5% and 16.1% lower than that consumed by the base design of the proposed process and a published base case, respectively. Additionally, the exergy efficiency of the proposed process is 47.2%. This study will help process engineers achieve a sustainable green economy by improving the competitiveness of H₂ storage and transportation over long distances.