[en] The purpose of this study was to evaluate the use of an external counting technique to provide daily monitoring of kidney transplant function by measuring the renal clearance of Tc-99m(Sn)DTPA. During the first few weeks following transplant, 15 patients had their renal clearance of Tc-99m DTPA measured daily over periods of 5-24 hr. Clearance rates were compared with daily plasma creatinine levels, and the effects of diurnal variation, drug treatment, and physical activity noted. The results show that any significant fall in clearance rate of chelate, indicating a rejection episode, preceded a rise in plasma creatinine levels by at least 24 hr. One episode of transplant failure presented as a sudden deterioration in clearance rate of chelate; in the others the change was more gradual but was still apparent within hours. It is considered that this noninvasive, low-dose, easy-to-perform technique is of considerable value in extended daily monitoring of renal function and is superior to standard daily or twice-weekly renography for the early detection of transplant rejection

[en] Short communication

No abstract available

[en] Abstract only

No abstract available

[en] In a study of 100 patients referred for assessment of renal function a comparison is made between gamma camera computer assisted displays of sup(99m)Tc-DTPA(Sn) nephrograms, I.V.U. X-rays and triple probe ¹³¹I-renography. The computer processed data displays renal morphology and an activity/time curve which is deconvoled to enable quantitative assessment of glomerular function to be made. Pattern recognition techniques for feature extraction are employed to emphasize and facilitate detection of changes in the shape of the curve. We conclude that the computer processed data gives better results both in the recognition of morphological defects and in the indication and measurement of renal damage

[en] The purpose of this study was to evaluate the use of an external counting technique to provide daily monitoring of kidney transplant function by measuring the renal clearance of Tc-99m(SN)DTPA. During the first few weeks following transplant, 15 patients had their renal clearance of Tc-99m DTPA measured daily over periods of 5 to 24 h. Clearance rates were compared with daily plasma creatinine levels, and the effects of diurnal variation, drug treatment, and physical activity noted. The resuls show tht any significant fall in clearance rate of chelate, indicating a rejection episode, preceded a rise in plasma creatinine levels by at least 24 hr. It is considered that this noninvasive, low-dose, easy-to-perform technique is of considerable value in extended daily monitoring of renal function and is superior to standard daily or twice-weekly renography for the early detection of transplant rejection

[en] Technetium polyphosphate uptake by breast tumours was investigated in 69 patients. Although 70% (38 out of 54) of malignant tumours took up the isotope in comparison with 45% (5 out of 11) of benign lesions, this technique would be unreliable for diagnostic purposes. (author)

[en] Factor analysis of dynamic structures (FADS) has been used in the interpretation of dynamic scintigraphic studies since the technique was described by Bazin et al. (1980). This study was designed to analyse to what extent, if any, does physiological factor analysis of dynamic renal data really help the clinician and by how much the method improves the diagnostic accuracy when compared to deconvolution analysis and parenchymal transit time (PTT) measurements. One hundred and fifty patients who were clinically, biochemically and radiologically investigated for renal disease were included in the study. Fifty of these were found to have no clinical evidence of renal disease, 50 were diagnosed as having non obstructive kidney disease and 50 had evidence of renal obstruction. Data obtained from ^99mTc-DTPA renography were processed using deconvolution (with PTTs) and physiological factor analysis and the results compared by ROC analysis. Clinically the information gained from factor analysis was superior to that obtained from deconvolution with PTT measurements in that a more accurate differentiation between an obstructive nephropathy and an obstructive uropathy was obtained. It is considered that physiological factor analysis enhances the clinical information obtained from renography, increases diagnostic accuracy and obviates the need for diuresis renography. (orig.)

No abstract available