[en] A set of reactivity indices, including maps of the electrostatic potential and local and condensed Fukui function (FF) indices in the atomic resolution, are reported for two vasoconstricting mycotoxins: butenolide and ergotamine; both the finite difference approach of Parr and Yan as well as charge sensitivity analysis, determining the charge responses via the inversion of the hardness tensor, have been used to generate the FF data. These two routes of arriving at the atomic FF indices provide an opportunity to evaluate the available parametrizations of the semiempirical NDDO-type of methods which have been used to determine the input charge distribution; namely, the best parametrization should generate consistent FF predictions resulting from both approaches. For butenolide, the MNDO parametrization was found to fulfill this consistency requirement. The chemical reactivity information has been used to trace possible similarities in reactivity trends of the butenolide molecule and the related fragment of ergotamine, toward hypothetical nucleophilic, electrophilic, and radical attacks. These predictions have been compared to experimental data available for other unsaturated lactones. 13 refs., 18 figs., 1 tab

[en] Charge sensitivity analysis (CSA) is carried out for model toluene-vanadium pentoxide chemisorption complexes involving the two-pyramidal model of the active site on the (010)-V₂O₅ surface. Maps of the electrostatic potential around the adsorbate and the substrate cluster are used to rationalize energetical preferences of alternative perpendicular and parallel arrangements of the toluene ring relative to the pyramid bases, known from previous SCF MO studies. The minimum-energy coordinates (MEC) in the electron population space are determined from the CSA semiempirical, finite difference atomic hardness matrix for the actual SCF MO charges in the chemisorption clusters. They represent collective charge displacements which minimize the system energy per unit change in the oxidation state of a specified atom, thus providing a convenient diagnostic tool for testing the alternative charge rearrangements and range of perturbations due to the chemisorption bond or changes in the cluster environment. The MEC relaxed hardnesses diagnose mode stabilities and together with the MEC relaxed hardnesses diagnose mode stabilities and together with the MEC topologies identify the most probable locations of the adsorbate activation. Finally, the atomic Fukui function indices are used to explore trends in the distribution of the external charge transfer due to the system environment. 14 refs., 4 figs

[en] Two intracranial hemorrhages occurred in a young child with hemophilia A. Difficulties in diagnosis and treatment are described. Both incidences ended with a full cure.(author)

[en] Aim: Analysis of classical prognostic factors in patients with non-advanced endometrial cancer treated with postoperative radiotherapy. Materials/Methods: In the years 1985 - 1999, 705 patients underwent postoperative radiotherapy due to endometrial cancer: 529 patients with FIGO stage I and 176 with FIGO stage II cancer. Mean age was 58 years. In 96% of patients endometrioid adenocarcinoma was found. In 49.9% the cancer had a high, in 27.9% a medium, and in 22.2% a low degree of differentiation. Results: 82% of patients had 5-year disease-free survival. In univariate analysis a significantly higher rate of disease-free survival was observed in: patients younger than 60, with moderately and well differentiated cancers, with stage I endometrioid adenocarcinoma with less than 50% myometrial invasion. In multivariate analysis degree of cancer differentiation was the only independent prognostic factor. Conclusions: In a group of patients with non-advanced endometrial cancer treated with postoperative radiotherapy, degree of cancer differentiation is the primary prognostic factor. (authors)

No abstract available

[en] The aim of the study was comparison of the results of sequential and concurrent chemoradiotherapy in patients with advanced inoperable NSCLC. Between 2001-2004 in the group of 173 patients with locally advanced, inoperable NSCLC the randomized, prospective clinical trial was conducted. The study group consisted of 2 arms: in 89 patients neoadjuvant chemotherapy plus teleradiotherapy was used; in 84 patients concurrent chemoradiotherapy was given. In both groups conformal radiotherapy and 2-drug chemotherapy cisplatin and navelbine was given. The only difference between the two groups was the sequence of radiotherapy and chemotherapy. The similar benefit of both methods adding chemotherapy to radiation therapy was established. 2-year overall survival and disease free survival in sequential therapy arm was 25.8% and 11.2% and in concurrent therapy group 25.0% and 11.9%, respectively. The rate of toxicity of treatment in concurrent therapy arm was statistically significantly higher; full treatment according to the plan was given to 96.7% patients treated sequentially and to 75% in concurrently treated group. The results of sequential and concurrent chemoradiotherapy in locally advanced inoperable NSCLC are very much the same but the toxicity due to treatment was significantly higher in the latter group. (author)