[en] Magnetron sputtering ion plating and plasma spraying have been used to make aluminium coating on beryllium substrate. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Auger electron energy spectrum (AES) and X-ray stress analysis were used to study microstructure and interface and residual stress and diffusion content of Al coating. The results show that width of diffusion zone made by magnetron sputtering ion plating is about 1 μm, coating is composed of columnar grains and internal stress of Al coating is about zero. Coating deposited by plasma spraying is not homogeneous and there are microcracks at interface

[en] Objective: To explore the clinical features, prognostic factors, and role of surgery, radiotherapy and chemotherapy in combined small cell esophageal cancer(C-SCEC). Methods: We retrospectively analyzed the clinical data of 32 Patients with C-SCEC from the Cancer Hospital of Tianjin Medical University between January 1989 and April 2012. The Kaplan-Meier method was used to estimate survival, and the log-rank test was used for univariate prognostic analysis. Results: A total of 29 patients (90.6%) participated in follow-up visits. The overall survival of the patients ranged between 4.3 and 86.5 months with a median of 13.5 months. The one-, two- and three- year survival rates were 55.3%, 31.6%, 15.8%, respectively. The univariate analysis showed that TNM stage (P = 0.01), N-stage (P = 0.01) and M-status (P = 0.02) were associated with OS; the number of chemotherapy cycles (≥ 4) and chemotherapy after location therapy (surgery or radiotherapy) nonsignificantly improved the OS in C-SCEC (P = 0.147 and P = 0.086). Conclusion: C-SCEC is major in Limited-stage, and multimodality therapy is recommended. TNM stage, N-stage and M-status are prognostic factors. Surgery combined with radiotherapy and chemotherapy may improve the OS. (authors)

[en] Objective: To observe the clinical effect of breast conserving surgery with adjuvant radiotherapy in breast cancer. Methods: 62 cases of patients with breast cancer in our hospital from 2011 June-2013 June were selected randomly, and were divided into two groups, 31 patients per group, breast conserving surgery with adjuvant radiotherapy in patients as study group, modified radical surgery with adjuvant chemotherapy as control group, analysis two group patients after treatment, cosmetic effect, therapeutic index, skin classification, and prognosis. Results: The study group breast cosmetic results excellent rate of 77.42%, higher than 32.26% in the control group, significant differences with statistical significance (P < 0.05); and the research group of bleeding volume, operation time, less than the control group, significant differences with statistical significance (P < 0.05); at the same time case the number of each grade of two groups of skin reactions after radiotherapy, and the prognosis of patients with local recurrence rate, distant metastasis rate, survival rate is the difference was not statistically significant (P > 0.05). Conclusion: Application of breast conserving surgery with adjuvant radiotherapy for breast cancer patients, significant effect, has a certain clinical value in research and application. (authors)

[en] The author describes the prediction of composition of Be/00Cr17Ni14Mo2 stainless steel joint following diffusion bonding by the finite element method. The relation of diffuse width and diffusion time is discussed. The results indicate that the simulative consistency curves fit well with the experience ones

[en] Corrosion mechanism of nickel deposit on depleted uranium surface prepared by pulse plating was studied by scanning electron microscopy (SEM), X-ray energy dispersion spectroscope (EDS) and electrochemical technology. The results indicate that in potassium chloride solution with 50 μg/g Cl^-, the corrosion of nickel deposit on uranium surface occurs at it's pit and extends to the interface between uranium and nickel deposit. The accumulation of corrosion product results in the cracking of nickel deposit. Because nickel is a cathodic coating for the uranium matrix, the galvanic corrosion will happen when they contact. The protection of nickel coating to uranium depends on the physical barrier of nickel coating to the corrosive medium. The densification of the nickel coating will improve the corrosion resistant performance of nickel coating to uranium. (author)

[en] By using the first-principles plane-wave ultrasoft pseudopotential method based on the density functional theory, we calculated the electronic structures and optical properties of intrinsic ZnO, Cu doped, Fe doped and Cu-Fe co-doped ZnO compounds. The results show that the Cu doped ZnO is P type doping, and Fe doped ZnO is N type doping. In the case of single doping, Cu-3d and Fe-3d state electrons increase the carrier concentration of ZnO and improve the conductivity of ZnO because of the formation of impurity levels in the forbidden band. The ZnO semiconductor enters the degenerate state and exhibits metallic properties in the case of Cu-Fe co-doped. The imaginary part of ZnO dielectric function changes mainly in the low energy region, the absorption coefficient and reflectance curve of the spectrum are red-shifted after doping. Among them, intrinsic ZnO has better transmittance to the solar spectrum, Fe single-doped and Cu-Fe co-doped ZnO have similar absorption effect to the visible spectrum, while Fe single-doped ZnO has lower spectral transmittance to the near-ultraviolet region, which is suitable for preparing anti-ultraviolet films. (authors)

[en] To obtain a flexible material to shield γ-rays, Gd₂0₃/XNBR (carboxylated nitrile butadiene rubber latex) flexible films were successfully prepared. The microscopic observation results showed that Gd₂0₃ was well-dispersed in XNBRL. The tensile strength, elongation at break, and hardness of the Gd₂0₃/XNBR flexible films were measured. The results suggested that Gd₂0₃/XNBR films were resistant to oil, acid, alkali, and hot air. The attenuation efficiencies of Gd₂0₃/XNBR films with different thicknesses and percentages of Gd₂0₃ were obtained. The Gd₂0₃/XNBR films showed good attenuation effect on 51-90 keV γ-rays. (authors)

[en] Diffusion bonding of U-Al microsheets by hot pressing in vacuum was carried out under different temperatures, pressures and holding times. The microscopic analysis and energy spectrum analysis were applied to the bonding interface. The appropriate process parameters without diffusion layer were 350 ℃/63 MPa/1 h. Under the precondition of 1 h holding time, the process parameters for homogeneous diffusion layer were 400 ℃/80 MPa. The composition of homogeneous diffusion layer was mainly UAl₂. (authors)

[en] Highlights: • The aging kinetic of the Be/6061Al composite was accelerated. • The formation of GP zone in Be/6061Al composite was suppressed. • Mg and Si elements segregated on the Be/Al interface. • β″ precipitated independently or precipitated along dislocations in matrix. The aging behavior of Be/6061Al composites cannot indiscriminately copy the aging behavior of the 6061Al matrix alloy. In this study, the aging behavior of Be/6061Al composite (62% mass fraction of Be) fabricated by powder metallurgy technique was investigated by Micro Vickers hardness measurements, HRTEM and DSC experiments. Subsequently, the corresponding precipitation mechanism was discussed in detail. It was found that Be/6061Al composite exhibited an accelerated age hardening phenomenon as high density dislocations were incorporated by Be particles. The aging precipitation sequence of Be/6061Al composite was similar to 6061Al alloy, but the formation of GP zone was suppressed which can be attributed to the decrease of vacancy concentration caused by Be/Al interfaces and the segregation of Mg and Si on Be/Al interfaces.

[en] Objective: To explore the possibility that metformin enhance radiosensitivity and its potential mechanism in lung cancer A549 cells. Methods: CCK8 assay was conducted to determine the IC50 value of metformin in A549 cell. The radiosensitizing effect of metformin in A549 cell on survival curve after radiation were detected by cell colony assay. Flow cytometry with Annexin V-PI staining was used to assess the apoptosis and cell cycle arrest. The expression of DNA damage protein γ- H2AX and DNA repair protein, such as DNA-PK, Ku80, Ku70, were detected by Western Blot analysis. Results: We found that metformin at 5 mm concerntration enhanced the radiosensitivity of A549 cell. Cell colony assay showed that the cell survival fraction (SF) was 1.39 after radiation combined with 5 mm metformin for 24 hours, and the SF value was 0.1 in radiation alone group. Flow cytometry showed that the ratio of G2/M phase after 6 Gy combined with 5 mm metformin group was 8%, the early apoptotic rate was 34.9%, but its ratio of 6 Gy was 26%, the early apoptotic rate was 10.6%. Western blot showed that metformin significantly down-regulated the expression of DNA repair protein such as DNA-PK. Ku70 and Ku80 and up-regulated the expression of DNA damage repair γ-H2AX protein after 6 Gy combined with 5 mm metformin for 24 hours (P < 0.01). Conclusion: In vitro, we found that the mechanism about radiosensitivity of metformin was to reduce G2 checkpoint and inhibit DNA damage repair. (authors)