[en] Objective: To discuss the difference in curative effect between ultrasound-guided microwave ablation (MWA) and surgical resection in treating early alveolar hepatic echinococcosis. Methods: The clinical data of a total of 40 patients with early alveolar hepatic echinococcosis, who were admitted to authors' hospital during the period from June 2015 to June 2017 to receive treatment, were retrospectively analyzed. According to the treatment method, the patients were divided into MWA group (n = 20) and surgery group (n = 20). The serum levels of total bilirubin (TBIL), alanine transaminase (ALT), aspartate transaminase (AST), platelet count (PLT), white blood cell (WBC) count, hemoglobin (HGB) and albumin (ALB), the postoperative complications, and the recurrence of disease were compared between the two groups. Results: No statistically significant differences in preoperative serum levels of AST, ALT, TBIL, WBC, HGB, ALB and PLT existed between the two groups (P > 0.05). The differences in postoperative serum levels of TBIL and PLT between the two groups were not statistically significant (P > 0.05). The postoperative serum levels of ALT, AST and WBC in MWA group were remarkably lower than those in surgery group (P < 0.05), while the postoperative serum levels of HGB and ALB in MWA group were strikingly higher than those in surgery group (P < 0.05). In MWA group, no postoperative infection, renal failure, liver failure, biliary leakage, or bleeding occurred, and postoperative follow-up imaging examination indicated that the lesions were stable and no signs of recurrence were observed. In surgery group, one patient developed postoperative infection, no renal failure, liver failure, biliary leakage, bleeding, or recurrence occurred. Statistically significant differences in postoperative hospitalization days and total medical expenses existed between the two groups (P < 0.05). Conclusion: For the treatment of early alveolar hepatic echinococcosis, MWA can achieve satisfactory results. MWA is superior to surgical resection in rapid postoperative recovery, short hospitalization period and low medical expenses. (authors)

[en] Objective: To investigate the expression and subcellular localization of RNA-binding protein Ro60 in neoplasms before and after γ-ray irradiation, and the function of Ro60 in tumor cell proliferation and radio-sensitivity. Methods: The eukaryotic expression plasmid of mGFP-Ro60 was constructed and transfected into HCT116 and MCF7 tumor cells. The cellular localization of Ro60 was examined before and after irradiation. Cell proliferation and radio-sensitivity were detected by CCK8 and trypan blue assay. Results: The result of immunoblotting showed that tumor cells expressed Ro60 protein. The irradiation increased Ro60 expression and induced significant nuclear aggregation of Ro60. The cell proliferation before and after irradiation was drastically reduced while cell death increased in Ro60 over expressed tumor cells. Conclusion: γ-ray irradiation alters Ro60 expression and localization, and Ro60 plays an important role in tumor cell proliferation and radio-sensitivity. (authors)