[en] The aim of the study was to present the brain metabolic changes in HIV-positive patients at different stages of the disease using HMRS. MRI and HMRS were performed in 19 patients (4 women, 15 men), 23 to 49 years old, using 1.5 T Signa Horizon (GEMS) MR system. In 4 patients AIDS dementia complex was clinically confirmed (group 1), while the remaining patients had no clinical changes relating to CNS (group 2). MRI. In the group 1, brain atrophy and focal hyperintense lesion in T2-weighted MR images, hypointense lesion in T1-weighted MR images in the centrum semiovale and in the periventricular white matter, were dominant. In the group 2, in 10 cases no CNS changes were observed and in 5 remaining cases moderate degree of brain atrophy was noticed. HMRS: In the group 1, a significant decrease of NAA/Cr, an increase of Cho/Cr, mI/Cr and Lac/Cr ratios were observed. In the group 2, an insignificant decrease of NAA/Cr ratios, a moderate increase in Cho/Cr, and a significant increase mI/Cr ratios were observed. HMRS is a method that broadens CNS diagnostic potential in HIV-positive patients. It enables us to determine the phase of the process involved and image metabolite changes in cases without morphological manifestation. (author)