Clinical investigation of predictors of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy
AbstractAbstract
[en] We investigated 710 patients with breast cancer who received radiotherapy after breast-conserving surgery at our institution to evaluate the incidence of radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome focusing on the interval from irradiation to onset and the clinical presentation. The predictive value of age (≤50 or >50), chemotherapy and hormone therapy was statistically analyzed to determine whether these are risk factors for BOOP syndrome. Radiation-induced BOOP syndrome was seen in 1.3% (9/710). In most cases, the symptoms were mild and none of the patients required hospitalization. Eight patients (88.9%) responded well to steroid administration, but 5 of these patients relapsed after or during tapering of steroids. Although we could not detect significant risk factors for BOOP syndrome, a higher patient age was associated with a higher incidence of radiation-induced BOOP syndrome after breast-conserving therapy. (author)
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Nyugan No Rinsho; ISSN 0911-2251; ; v. 26(3); p. 327-333
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BIOLOGICAL EFFECTS, BIOLOGICAL RADIATION EFFECTS, BODY, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DISEASES, DOSES, ELECTROMAGNETIC RADIATION, GLANDS, IONIZING RADIATIONS, IRRADIATION, MEDICINE, NEOPLASMS, NUCLEAR MEDICINE, ORGANIC COMPOUNDS, ORGANS, RADIATION EFFECTS, RADIATIONS, RADIOLOGY, RESPIRATORY SYSTEM, THERAPY, TOMOGRAPHY
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