Drug Discovery News

Glioblastomas are filled with immature astrocytes. Identifying how to coax these cells into maturity may offer new treatment pathways for this often fatal cancer. Read more: https://ow.ly/3ufn50UBqmW

Denali Therapeutics' oligonucleotide transport vehicle improves therapeutic delivery across the blood-brain barrier. This transport vehicle offers a promising non-invasive approach for treating neurodegenerative diseases. Read more: https://ow.ly/zajr50UB3AA

Fibrinogen is a protein that helps blood clot, but Mark Petersen’s team at University of California, San Francisco found that when it leaks into the brains of premature infants, it can cause long-term damage. Read more about their study in this story: https://ow.ly/1pR850UsZEN

The APOE4 gene is a known risk factor for Alzheimer’s disease. Lexeo Therapeutics is running a clinical trial testing whether a gene therapy that delivers a protective version of the gene, APOE2, could treat Alzheimer’s disease. Read more: https://ow.ly/e3tl50Usb1K

Over 80 percent of American adults with prediabetes are unaware of their condition. Regular checkups and blood tests are crucial for early detection and prevention, as are lifestyle changes such as eliminating refined carbohydrates and incorporating exercise. Here’s what we know so far about the science of reversing prediabetes: https://lnkd.in/g-GtSNh6

By quantifying the tiny forces platelets generate, scientists hope to gain deeper insights into clotting mechanisms and improve treatments for disorders related to platelet dysfunction. Read more: https://ow.ly/v9vB50UmIH9

Current diagnostic methods for sleep disorders are costly and inaccessible. Metabolomics offers a potential alternative, providing precise biomarkers for impaired sleep. Read more: https://ow.ly/rynj50UoEuK

✨ Check out our top story for 2024 ✨ In the 1990s, Pfizer shelved an effective antipsychotic drug due to its side effects. Years later, Andrew Miller found a way to minimize the side effects. Read the story, here: https://ow.ly/YFaM50UxuXH And read our follow-up coverage of the drug's approval: https://lnkd.in/gbXGxeDK

✨Check out our top Q&A with a Pharma executive from 2024✨ Sanofi’s new oral TNFR1 inhibitor shows promise in treating rheumatoid arthritis. Elizabeth Laws, Head of Immunology and Inflammation, spoke about her and her team aim to replace less effective injectables with this new oral option. Read more: https://ow.ly/bs7m50Uxv53

✨Check out our top DDN Dialogues podcast episode from 2024✨ Actinium-225 emits high energy alpha particles that bust up tumor DNA, killing cancer cells. Researchers developed a new way to make more of it for clinical trials and eventual treatments. 🎧Listen here: https://ow.ly/4J8O50Uxv2T