Keto-Mojo

The evidence shows that patients who receive instant feedback on their dietary choices have higher rates of compliance. That's why real-time monitoring of patient health data can be a game-changer for health practitioners who, in the past, have had to rely on the memory and honesty of patients in reporting compliance with their treatment programs. With MyMojoHealth, practitioners can quickly scan their patient's blood glucose and ketone readings on a daily or weekly basis and identify the patients that need more attention. Learn more about the free MyMojoHealth platform for healthcare practitioners here: https://lnkd.in/ghUcjDcT #keto #ketomojo #healthcare #remotepatientmonitoring https://lnkd.in/gVNr-3CK

This week’s Spotlight on Keto Research highlights how ketogenic therapies impact a wide range of applications: 🌸 Hormonal Health: Keto’s potential in managing PCOS 🦴 Bone Regeneration: Bioenergetic boosts for bone healing 💪 Joint Protection: Anti-inflammatory effects of BHB in haemophilia 🧠 Brain Health: Intermittent fasting’s role in supporting cognitive resilience 🦠 Gut-Liver Signaling: How gut microbes enhance the effects of ketogenic diets   👉 Subscribe and stay informed on cutting-edge research! #MetabolicHealth #KetogenicTherapies

The impact of early-life sugar exposure on long-term health has become a critical area of research, especially as chronic diseases like diabetes and hypertension continue to rise globally. This study examined the effects of sugar restriction during the first 1000 days of life on risks of developing diabetes and hypertension. Researchers used a natural experiment from the United Kingdom, where sugar rationing ended in September 1953, nearly doubling sugar consumption afterward. The study compared adults conceived just before and after this change in sugar intake using data from the UK Biobank. Findings on Diabetes and Hypertension: 🔹Individuals exposed to sugar rationing during early life experienced a 35% reduction in diabetes risk and a 20% reduction in hypertension risk. 🔹On average, diabetes onset was delayed by 4 years and hypertension onset by 2 years. Timing and Duration Mattered: 🔹In-utero sugar restriction contributed to about one-third of the risk reduction, while postnatal restriction, particularly beyond 6 months, accounted for the majority of the health benefits. 🔹The protective effects were strongest for individuals who continued to experience sugar restriction through early infancy, aligning with the period when solid foods are often introduced. Mechanisms: 🔹Physiological Programming: Early sugar restriction may alter metabolic programming in the womb, affecting long-term disease risk. 🔹Taste Preferences: Reduced early-life sugar exposure may prevent lifelong preferences for high-sugar foods, reducing consumption later in life. Implications for Public Health: 🔹These findings add weight to ongoing discussions about policies aimed at reducing sugar consumption, especially in foods marketed to infants and young children. In summary, these findings confirm the importance of limiting early sugar exposure for long-term metabolic health. Further research is needed to investigate optimal sugar intake limits during critical early stages of development, including pregnancy, lactation, and infancy. ---- Gracner et al. Exposure to sugar rationing in the first 1000 days of life protected against chronic disease. Science. 2024; 10.1126/science.adn5421 📌 Link to study: https://lnkd.in/gB4gVWnX 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #KetoDiet #Research

🎉 We’re kicking off the new year with the first edition of Spotlight on Keto Research, bringing you the latest scientific insights in ketogenic science… just like in 2024! In this issue: 🦠 Cancer & Metabolism: How fructose-driven lipid transfer fuels tumor growth 🔥 Inflammation Control: How β-hydroxybutyrate regulates immune responses at the molecular level 💪 Metabolic Health: Improving heart health, liver fat, and cholesterol through dietary adjustments ⚖️ Obesity: Unlocking the potential of ketogenic diets for obesity-related conditions Stay at the forefront of keto science as we dive into another year of groundbreaking research ✨ Click below to read more! #MetabolicHealth #KetogenicTherapies

Obesity is a significant risk factor for knee osteoarthritis, and weight loss is critical for osteoarthritis management. This pilot study evaluated the effects of a 20-week very low-calorie ketogenic diet (VLCKD) on weight loss, knee osteoarthritis symptoms, and quality of life in women with obesity. A total of 20 women with a BMI ≥ 30 kg/m² and symptomatic knee osteoarthritis were enrolled; 16 completed the study. The VLCKD included an 8-week ketogenic phase followed by a gradual reintroduction of carbohydrates over 12 weeks. Body mass index (BMI), knee function (WOMAC Index), quality of life (EQ-5D), and overall health (SF-36) were measured at baseline (T0), week 8 (T8), and week 20 (T20). Key Findings: 👉 Significant weight loss: from baseline BMI 40.0 ± 4.8 kg/m² to 37.5 ± 4.5 at T4, 36.3 ± 4.6 at T8, and 34.8 ± 4.8 at T20 (p < 0.001 for all comparisons). 👉 Improved knee function: WOMAC score improved from 43.6 ± 16.9 at baseline to 30.2 ± 12.8 at T4 (p = 0.005), 24.7 ± 10.6 at T8 (p = 0.001), and 24.8 ± 15.9 at T20 (p = 0.005). The reduction in BMI was strongly correlated with improvements in WOMAC scores. 👉 Enhanced quality of life: significant improvements were observed in EQ-5D and SF-36 scores, correlating with BMI reduction. 👉 Tolerability and safety: no major adverse effects were reported, though 2 participants discontinued due to mild side effects. In summary, a 20-week VLCKD effectively reduced weight and improved knee function and quality of life in women with obesity and knee osteoarthritis. These findings support further research to confirm the role of ketogenic diets in managing osteoarthritis symptoms and obesity-related comorbidities. — Ciaffi, J.; Mancarella, L.; Pederzani, G.; Lisi, L.; Brusi, V.; Pignatti, F.; Ricci, S.; Vitali, G.; Faldini, C.; Ursini, F. Efficacy, Safety, and Tolerability of a Very Low-Calorie Ketogenic Diet in Women with Obesity and Symptomatic Knee Osteoarthritis: A Pilot Interventional Study. Nutrients 2024;16:3236. 📌 Link to study: https://lnkd.in/dDbdUwYX 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #KetoDiet #Research #Osteoarthritis

The ketogenic diet continues to receive interest for its ability to improve insulin sensitivity and glycemic control, promote weight loss, reduce inflammation, and enhance cognitive function. However, its effects on cardiovascular disease (CVD) and mortality remain debated due to concerns about its high fat content. A recent study used National Health and Nutrition Examination Survey (NHANES) data from more than 40,000 people from 2001–2018 to explore the ketogenic diet’s impact on all-cause and CVD mortality. Dietary intake data were collected through two 24-hour NHANES surveys—one face-to-face and one by phone—allowing participants to recall food and beverage intake, with energy and nutrient values calculated from these averages. The Dietary Ketogenic Ratio (DKR) was then calculated to assess the participants’ adherence to the ketogenic diet. This calculation uses a specific formula combining fat, protein, and net carbs to create a DKR value from 0 to 9, with higher values indicating a stronger likelihood of reaching ketosis. Cox regression models were used to examine mortality risks. After adjusting for confounding factors, the researchers reported the following results: 🔷All-cause mortality: Higher DKR was associated with a reduced risk of all-cause mortality. 🔷CVD mortality: No significant association was observed between DKR and cardiovascular disease mortality. 🔷Subgroup findings: The protective effect of the ketogenic diet on all-cause mortality was more pronounced in older women and non-smokers. Although this is an observational study based on self-reported food intake, these results suggest that a ketogenic diet may potentially lower overall mortality risk without increasing cardiovascular death. However, further research is needed to confirm these findings and better understand its long-term health effects. — Qu X, Huang L, Rong J. The ketogenic diet has the potential to decrease all-cause mortality without a concomitant increase in cardiovascular-related mortality. Sci Rep. 2024 (14) 22805. 📌 Link to study: https://lnkd.in/eP98WCzD 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Ketogenic #Keto #Research

🔥 Best of 2024 in Keto Science! 🔥 2024 has been an exceptional year for ketogenic science! 🔬 This special edition of Spotlight on Keto Research features some of the most transformative studies advancing our understanding of ketogenic therapies: 🌿 Metabolic Health: Insights in diabetes remission and cardiovascular care 🧠 Brain and Mental Health: Promising results for bipolar disorder, schizophrenia and Alzheimer’s 🧬 Cancer Research: Innovative strategies targeting tumor metabolism Wrap up 2024 with a deep dive into the most impactful keto research of the year! #MetabolicHealth #KetogenicTherapies

During aging, the body’s nutrient-sensing systems, especially the growth hormone and IGF-1 pathways, can become disrupted. While these pathways promote cell growth, elevated levels are also linked to increased risks of cancer and other diseases. Evidence shows that diets like severe calorie restriction or fasting can reduce IGF-1, but these approaches are unsustainable and pose risks, especially in older adults or cancer patients. Recent findings suggest that ketogenic diets, which induce ketosis by limiting carbohydrates and increasing fats, can lower IGF-1 levels safely without calorie restriction, showing potential in aging and cancer management. A systematic review and meta-analysis assessed the impact of ad-libitum ketogenic diets on serum levels of insulin-like growth factor-1, glucose, and insulin across various adult populations, including those with cancer and other health conditions, examining studies that measured compliance through blood or urine ketone levels. Results: → IGF-1: A 20% reduction in IGF-1 levels was observed in participants following ketogenic diets, with consistent results across both cancer and non-cancer groups. → Glucose: Fasting glucose decreased by an average of 6% in nine studies, although there was considerable variation among the results. → Insulin: Fasting insulin levels were reduced by an average of 29%, with significant decreases reported in most studies. This study highlights the potential of the ketogenic diet as a viable alternative to calorie restriction for reducing IGF-1, glucose, and insulin levels, potentially benefiting metabolic health, cancer treatment, and healthy aging. Further research is recommended to explore long-term effects and optimize dietary protocols for broader applications. Would you try a ketogenic diet for long-term health? Let us know below! ⬇️ — Rajakumar G, Cagigas ML, Wang T, Pan AY, Pelaia T, Fuller SJ, Fontana L. Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis. Ageing Res Rev. 2024 Oct 11:102531 📌 Link to study: https://lnkd.in/eG8sfPhA 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #KetoDiet #Research

Check out this week’s Spotlight on Keto Research for the latest science behind transformative dietary strategies and their broad therapeutic applications. What's inside 👉 🥑 The latest on low-carb diets for cardiometabolic risk reduction 🧠 How do ketogenic diets impact migraines, sleep, and mental health? 🧪 Could fasting-mimicking diets boost cancer therapy? Click below to read and subscribe for updates on the evolving science of nutrition and health! #KetogenicTherapies #MetabolicHealth

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited cause of kidney failure, with limited treatment options available that do not achieve regression. Recent research has indicated that specific dietary changes could help slow ADPKD progression by targeting metabolic vulnerabilities of cyst cells. Cyst cells in ADPKD rely heavily on glucose and are unable to effectively use fatty acids and ketones for energy. High-carbohydrate diets can worsen disease progression, while renal stressors like oxalate, phosphate, and uric acid further stress the kidneys. RenNu was a remote, dietitian-supervised educational program developed based on these insights, to help individuals with ADPKD make sustainable dietary and lifestyle changes aimed at improving kidney health. RenNu involved four phases - orientation, plant-focused ketogenic diet phase, fat-adapted phase, and maintenance - where participants received education on the science behind the diet, self-measurement of health parameters, and nutrient tracking. Patients also used a medical food containing the ketone beta-hydroxybutyrate and alkaline citrate, along with in mindfulness exercises. This article reported the first experience with the RenNu program and beta testing with 24 participants. Key findings: 🔷 High adherence and feasibility: A total of 22 participants completed the program; 13 participants responded that they were very likely to continue a ketogenic lifestyle after the program. 🔷 Health improvements: Participants reported various health benefits, including reductions in pain levels, weight loss, better management of hypertension, and improved kidney function (eGFR). The initial experience with the RenNu program was highly positive in terms of both adherence and clinical outcomes. The program is now publicly available for individuals with ADPKD to learn and implement kidney-safe, ketogenic lifestyle changes. — Bruen, D.M.; Kingaard, J.J.; Munits, M.; Paimanta, C.S.; Torres, J.A.; Saville, J.; Weimbs, T. RenNu, a Dietary Program for Individuals with Autosomal-Dominant Polycystic Kidney Disease Implementing a Sustainable, Plant-Focused, Kidney-Safe, Ketogenic Approach with Avoidance of Renal Stressors. Kidney Dial. 2022, 2, 183–203.   📌  Link to study: https://lnkd.in/gqUKTy8p   📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN   #Keto #KetoDiet #Research Thomas Weimbs Jessianna Saville, MS, RDN, LD, CLT