OZ Biosciences

The OZ Biosciences team wishes you all a Happy Thanksgiving!

🌟 Product Launch Announcement! 🌟 We are thrilled to introduce our new product: saRNA Replicon GFP & LUC!🧬 Discover saRNA's 5 key features: ✔ High level of Luciferase protein expression with increased duration (until 1 month !). ✔ Stabilized at the 5' end by modified nucleotides (Cap1) and containing a poly(A) tail at the 3' end. ✔ New generation of RNA vaccines. ✔ Replicon delivery can be achieved with non-viral vehicles such as liposomes or lipid nanoparticles (LNPs). ✔ Available in Unmodified or m5C version. To discover more about our saRNA, visit our website ➡ https://lnkd.in/dixcmNf4 #Biotechnology #Research #Innovation #mRNA #saRNA

[#MabDesignMember]- ZOOM ON about [#OZBiosciences] OZ Biosciences is a product development company that creates, develops and commercializes delivery systems of bioactive materials (DNA, siRNA, mRNA, proteins, antibodies...), intended for the worldwide scientific community and pharmaceutical industries. To know more : https://lnkd.in/e_dMdkBU

Welcome to all #SINPAIN partners in Marseille. We are having a great progress meeting ! This great project aimed to develop a new therapy that combine siRNA technology, nanocarriers and an improved hyaluronic acid-based knee viscosupplement (IA-HA) for osteoarthritis treatment siNPAIN, Damien Dupin, Angela Moncada Pazos, Tom Roussel, Elise Bonvin, Janine Jost, Neill Liptrott, meriem lamghari, Nuria Coderch Marco, Paolo Gargiulo, Annalisa Chiocchetti, Magali Cucchiarini, Joan Cabellos, Daniela Vasconcelos, Davide Raineri, Ida Maruotto, Halldór Jónsson, Bruno Peault, Olivier Chassande, Christopher David #Osteoarthritis, #OAresearch, #nanotherapeutics, #kneeOA, #kneepain, #painrelief, #siRNA, #LNP

🎓 Scientific Highlight of the Week 🎓 We are delighted to share insights from a groundbreaking study entitled "Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis" published in Journal of Cell Biology by Viktória Szentgyorgyi et al: https://lnkd.in/dw9Xvazn Congratulations to all authors for this great article. They showed that lipopolysaccharide responsive beige-like anchor protein is recruited by members of the small GTPase Arf protein family to the TGN and to Rab4+ endosomes, where it controls intracellular traffic. In patient-derived fibroblasts, loss of LRBA led to defects in the endosomal pathway promoting the accumulation of enlarged endolysosomes and lysosome secretion. Our Helix-IN transfection reagent was used to transfect HeLa cells to generate CRISPR-Cas9 KO cell line. Viktória Szentgyörgyi, Leon Lück, Daan Overwijn, Danilo Ritz, Nadja Zoeller, Alex Schmidt, Maria Hondele, Anne Spang, Shahrzad Bakhtiar #transfection, #Hela, #crispr, #cas9, #geneediting, #endosomes, #metabolism, #severeimmunedysregulation, #lipopolysaccharide, #ozbiosciences

Check out our mRNA custom service platform and mRNA off-the-shelf. They are stabilized with 5’ Cap 1 structure and 3’ poly(A) tail and are optimized to yield improved stability & performance. They can be unmodified or modified with 5-methoxyuridine or N1-methyl-pseudouridine and/or fluorescent probe. #mRNA

Trick or Treat! Happy Halloween from OZ Biosciences' team

We're delighted to introduce Tom, our newest team member at OZ Biosciences 🎆 🎉 Tom joins us as a Formulation Scientist in Marseille, France. 🚀 His mission is to develop and support the formulation platform especially lipid nanoparticles (LNP), polymeric nanoparticles (PNP) and all other nanoparticles-based delivery systems such as liposome, lipoplexes or polyplexes. He is dedicated to execute a skilled and innovative research. 💼 🌟 Please join us in welcoming Tom to the OZ Biosciences family! 🎈 Florent Poulhès, Sofia Slaoui, Sophie Hubert, Elise Bonvin, Antonin Vinck, Mélanie Le Clech, Chloé De Vita, Tom Roussel #ozbiosciences, #magnetofection, #transfection, #transduction, #bioproduction, #mRNA, #LNP, #nanoparticles, #nanosciences, #polymers

🎓 Scientific Highlight of the Week 🎓 We are happy to share insights from a genuine study entitled "RNA G-quadruplexes form scaffolds that promote neuropathological a-synuclein aggregation" published in Cell by Kazuya Matsuo et al: https://lnkd.in/dY_Xfw8w Congratulations to all authors for this great article. They demonstrate that RNA G-quadruplex assembly forms scaffolds for a-synuclein aggregation, contributing to neurodegeneration. The administration of 5-aminolevulinic acid, a protoporphyrin IX prodrug, prevents RNA G-quadruplex phase separation, thereby attenuating a-synuclein aggregation, neurodegeneration, and progressive motor deficits in a-synuclein preformed fibril-injected synucleinopathic mice. Our NeuroMag transfection reagent (Magnetofection) was used to transfect primary mouse cortical neurons. Sefan Asamisu, Hiroyoshi Suzuki, Atsushi Takeda #neuromag, #transfection, #neurons, #cortical, #parkinson, #dementia, #lewisbodies, #atrophy, #neurodegeneration, #neurosciences

October is Breast Cancer Awareness Month, a time to reflect on the critical importance of scientific advancements in the fight against this pervasive disease. OZ Biosciences is proud to contribute to these advancements, continuously striving to develop innovative solutions in cancer research. Together, through relentless dedication and cutting-edge technology, we move closer to a future where cancer can be effectively treated and ultimately eradicated. 💗 #BreastCancerAwareness, #OZBiosciences, #Research, #Innovation, #Hope