Pharma Crystallization Summit

Many thanks to the speakers, poster presenters, session moderators, sponsors, volunteer organizers, and all attendees, for a very successful PCS2024!!!

Kudos to Dr. Gerard Capellades, and his graduate students, Mitchell Paolello and Ibrahim Joel, and undergraduate students, Anne Nong, Ricardo Otake, Lily Rhoads and Steven Roth, for representing Rowan University Chemical Engineering at the Pharma Crystallization Summit last week! This summit that brings together major pharmaceutical companies provided valuable experiential learning about the pharma industry for our students. Under Dr. Capellades' mentorship, our students Ibrahim and Mitchell won first and third place awards, respectively, in the poster competition. Congratulations to all!

Working with PROTACS? The Pharma Crystallization Summit has a full agenda of great speakers, but there seems to be a little extra buzz around this talk: Vepdegestrant: Development of a Scalable Crystallization Process of a PROTAC Molecule, Dr. Noalle Fellah, Pfizer, USA Hope to see you in NJ next month!

Very grateful for the opportunity to present a poster on the salicylic acid-salicylamide phase diagram, which was one of my main projects during my co-op at Boehringer Ingelheim, and being awarded 3rd prize at the Pharma Crystallization Summit in Princeton, NJ. Many thanks to Gerard Capellades, Fredrik Nordstrom, Francesco Ricci, Ph.D., and Brian Linehan for all of their help, support and mentorship that culminated in this impactful work!

I had the opportunity to attend the #PharmaCrystallizationSummit on September 26th and 27th at Crowne Plaza, Princeton, NJ. It was a fantastic experience getting to know experts in the pharmaceutical industry and presenting my research. I'm looking forward to apply the knowledge I gained into my future work and to further advance my research in crystallization science! Big thanks to my advisor #ChristerAakeroy for giving me this incredible opportunity! #gradlife #crystals #drugdevelopment #poster #KSTATE

Working with PROTACS? The Pharma Crystallization Summit has a full agenda of great speakers, but there seems to be a little extra buzz around this talk: Vepdegestrant: Development of a Scalable Crystallization Process of a PROTAC Molecule, Dr. Noalle Fellah, Pfizer, USA Hope to see you in NJ next month!

Microsize (Micronization, Particle Size Engineering, Pharmaceutical Development) is proud to be a sponsor of the 5th Pharma Crystallization Summit hosted by J-STAR Research, Inc., Sep 26-27 in Princeton, NJ. The agenda is packed with important discussions, topical panels, and expert presenters including: > Shuang Chen from AbbVie > James Fostinis from Amgen > Jeremy Merritt from Eli Lilly and Company > Lotfi (Zack) Derdour from GSK > Dimitrios Zarkadas, PhD, PMP from Merck Animal Health > Alfred Lee from Merck > Noalle Fellah, PhD from Pfizer > Rajni M. Bhardwaj from Pfizer > Susan Reutzel-Edens from SuRE Pharma Consulting, LLC Learn about Microsize (Micronization, Particle Size Engineering, Pharmaceutical Development)'s post-crystallization particle size engineering & solubility optimizing technologies & capabilities: https://lnkd.in/eTUsmXRG #pharmacrystallizationsummit #particlesizeengineering #drugdevelopment #crystallization #solubility

Looking forward to all the great talks, discussions, and networking at this year's Pharma Crystallization Summit! I'll be there with our partner The Solubility Company to discuss our recent white paper... Unleashing Bioavailability: Particle Size, Salt Form, and the Race Against Disproportionation. 👉 You can read the white paper here: https://lnkd.in/erav-UFQ 📧 Message me if you want to learn more. #crystallization #particlesize #formulation #drugdevelopment

"It appears that the study of impurity purge mechanisms in solution crystallization is by and large the study of solid solutions" This statement (not mine, credit to Fredrik Nordstrom) concluded last year's study of impurity retention mechanisms on 52 product-impurity systems, primarily from industrial systems at Merck and Boehringer Ingelheim, where 79% justified the high levels of impurities in the solids as directly related to solid solution formation with process impurities (https://lnkd.in/eWpR7aF5). We now raise the questions: ➡ How do solid solutions behave, compared to the pure crystals, especially if the impurity is not evenly distributed throughout the lattice? ➡ Can we exploit this behavior to inform diagnostics and purification, or to develop novel formulations? ➡ What process factors can affect the uneven distribution of impurity (composition anisotropy) throughout the crystal, when mixing and higher supersaturations are involved? ➡ Could we have ignored the link between composition anisotropy and anisotropic growth/dissolution behavior in prior crystallization studies, leading to erroneous assumptions or incomplete conclusions? Check out the first paper of our "visualized" series, where we combine the fields of dyed crystals (yes, many are solid solutions) and impurity rejection, to show visual evidence of the differences in behavior between pure crystals and solid solutions. We're reporting new systems as dyed pharmaceuticals, and cross-validating those behaviors with well-known dyed crystals (including Kahr's famous Potassium Sulfate - Acid Fuchsin system). This work was spearheaded by three undergraduate students pursuing their Bachelor's degree, as part of Rowan University's research opportunities (Engineering Clinics) program: Anne Nong, Claire Schleper, Abigail Martin You can hear more about this research in the upcoming Pharma Crystallization Summit (Thursday afternoon talk, and student posters on Friday), as well as at the ACT (Association for Crystallization Technology) meeting in Boston next week. The paper is available #OpenAccess at CrystEngComm: https://lnkd.in/eQXaFiEs #CSPELab #Crystallization #Impurities #PharmaceuticalManufacturing #SolidSolutions #ImpurityRejection #DyedCrystals #Formulation #Purification

👋 Come say hi at the 5th edition of Pharma Crystallization Summit on 26 and 27 September. Bring along all your questions about #solid-state research, #process #development and #formulation to discuss with our team of experts Fernando Ferreira, MBA and Carmen Guguta. Will we see you there? #Technobis #PharmaCrystallizationSummit #Crystallization #DrugDevelopment #Pharma