On a Mission to SAVE the Microbiome from Extinction | TOP LinkedIn Voice In Research² l Inventor | Keynote | Author | Entrepreneur
Non-Sugar Sweetener Consumption Alters Duodenal Microbial Diversity and Metabolic Pathways: REIMAGINE Study #Mysummary In this study conducted at Cedars-Sinai, researchers analyzed duodenal and stool samples from individuals consuming non-aspartame non-sugar sweeteners (NANS, n= 35), aspartame (ASP, n=9), and controls (n= 55). The findings reveal that NANS consumption is associated with decreased microbial diversity in the duodenum, where nutrient absorption happens. Interestingly, the relative abundance of potentially harmful bacteria like E. coli, Klebsiella, and Salmonella was lower in the duodenum of both NANS and ASP consumers compared to controls, suggesting a potential beneficial effect. Is this an artifact?! The circulating levels of the pro-inflammatory cytokine IL-1β were decreased in NANS consumers compared to controls, suggesting alterations in immune responses. The cylindrospermopsin biosynthesis pathway, which is linked to potential liver toxicity, was enriched in ASP consumers, raising concerns given the recent classification of aspartame as a possible carcinogen. #Mythoughts I wish the authors had used metagenomics instead of 16S sequencing - we could have had a better view of the changes in the gut microbiota composition. More studies with a larger number of volunteers are needed but it should not prevent us from taking action and already reducing the consumption of any type of sweeteners. HAPPY to hear your THOUGHTS and stay POSITIVE! #Myinspiration "We did not come to fear the future. We came here to shape it." Barack Obama Link to the paper here: https://lnkd.in/ecUkBCwH #microbiome #microbiology #science #biology #nature #health #pharma #probiotics #nutrition #diet #nature
Dr. Amine ZORGANI thanks for sharing this insightful article. Coincidentally, my upcoming post will address the topic of #sweeteners, a subject I recently discussed and explored in an interesting review. As you aptly noted, the challenge in this area stems from the scarcity of comprehensive and comparable studies. This problem is typical of the complexity of #nutritional #science, where biases—ranging from participant demographics and pre-existing conditions to sampling methods and measurement techniques—can significantly alter study interpretations. However, it's encouraging to note that there are robust in-vitro and animal studies that provide valuable mechanistic insights. These studies, while not directly translatable to human models, contribute to our understanding by highlighting potential pathways and effects.
Agree to your thoughts 👌🏻
Hanen Jnen
8mo
👏🏻👏🏻
Nduta Karanja E
8mo
Very very fascinating
Co-Founder & CEO at NIUM
8moI am not so sure about the advice on reducing non-sugar sweeteners. Plenty of good evidence that they are beneficial compared to sugar, and if it helps people adhere to a healthier diet, then why not? When asked about "Is X good?" in dietary interventions, often we should add the caveat "...instead of what?". As for the microbiome impact, most of the studies I am aware, of showing an impact on diversity are not in humans and/or using incredibly high dosages. I would not raise too many concerns before having more conclusive evidence.