Great short video from Understanding Animal Research.
So far, for ethical, economical, and practical reasons, rodents (mice and rats) 🐭🐀 are currently the most used animals in preclinical studies. However, it's essential to acknowledge the significant role that experiments involving larger animals, like sheep and swine 🐑🐷, play in advancing our understanding of neurological disorders.
Unlike rodents with their lissencephalic brains, larger species possess gyrencephalic brains, akin to humans 🧠, and exhibit a higher white-to-gray matter ratio closer to our own. These factors are pivotal in comprehending the development of neurodegenerative diseases and underscore the importance of exploring diverse animal models.
By leveraging insights from both rodent and larger animal models, we can bridge the gap between preclinical studies and clinical applications more effectively, ultimately driving advancements in Neuroscience. #AnimalResearch #Neuroscience #BrainHealth
Did you know sheep are used to study neurodegenerative diseases such as Parkinson’s Disease?
Only 2% of total procedures in Great Britain are carried out on sheep, but they play an important role in studying neurodegenerative diseases. This is because they have similar neuroanatomical structures as humans.
Learn more on our website!
Credits - The University of Manchester case study: A day in the life of an animal technologist
#AnimalResearch #Research
Michael Fiore