Association for Single Cell Analysis (ASCA)’s Post

Synthesis, Spectral Characterization and Bioactivity of Co(II), Mn(II), Fe(II) and Fe(III) Complexes of Bidentate N,S Schiff Base of S-Benzyl Dithiocarbazate with p-(Dimethylamino)benzaldehyde

#OpenAccess #Article 🔎Title: A Tridentate Cu(II) Complex with a 2-(4′-Aminophenyl)Benzothiazole Derivative: Crystal Structure and Biological Evaluation for Anticancer Activity 🖋 Authors: Barbara Mavroidi et al. 📌 https://lnkd.in/dEfswYmN

✍ In this Synpacts article, Bidisha Paroi and Nitin T. Patil report the utilization of unconventional 1,6-heptadienes to develop the arylative Cope rearrangement by harnessing the interplay between the π-activation and cross-coupling reactivity mode of gold complexes. 🧪 Several mechanistic investigations such as 31P NMR study, HRMS analysis, cross-over experiment, control experiments were performed to support the proposed cyclization-induced [3,3]-rearrangement mechanism in arylative Cope reaction. 👀 Read it here: https://lnkd.in/eDAMa5uM

For the experts out there: how would you define “autophagy”? 1. Autophagy is the lysosomal/vacuolar degradation of cells-own material (De Duve, 1963) or 2. Autophagy is a lysosomal degradation pathway in which cytoplasmic material is sequestered within double membrane autophagosomes (recent literature)? No doubt for me: I stay with De Duve. Macro-autophagy is not a synonym of autophagy, is one of the possible pathways that ensures autophagy.

Question: Which among the following is an example of a nucleophilic substitution reaction? a) CH3CH2OH → CH2=CH2 + H2O b) CH3CH2Br + OH⁻ → CH3CH2OH + Br⁻ c) CH3COOH + CH3OH → CH3COOCH3 + H2O d) CH3CH2Cl → CH3CH2OH Answer: b) CH3CH2Br + OH⁻ → CH3CH2OH + Br⁻ Explanation: This is a SN^2 Bi molecular nucleophilic substitution reaction, where OH⁻ replaces Br⁻.

https://lnkd.in/dxnGBuZc Özten, Ö., Kuznetsov, A. E., Gokce, M., Erkan, S., Bulut, E., Taskin, O. S., … Güzel, E. (2023). Assessing cytotoxic activities, theoretical and in silico molecular docking calculations of phthalocyanines bearing cinnamyloxy-groups. Journal of Biomolecular Structure and Dynamics, 42(21), 11931–11941. https://lnkd.in/dXj8uktt

Fascinating and useful: "macrocyclization substantially improves kinetic solubility while not impairing the other measured parameters. We hypothesize that this could arise from “chameleonicity,” which was previously reported for large, natural-product-derived macrocycles." ("chameleonicity refers to a compound's capacity to adopt open and polar conformations in aqueous environments while assuming folded and less polar conformations in nonpolar environments such as cellular membranes. In practice, chameleonicity arises from conformational changes that modify the molecular properties of a compound in an environment-dependent manner." https://lnkd.in/gyQ6iyWn) #medicinalchemistry #drugdevelopment

#AnalyticaMDPI Check the #Communication 🔍 General Applicability of High-Resolution Continuum-Source Graphite Furnace Molecular Absorption #Spectrometry to the Quantification of #Oligopeptides Using the Example of Glutathione ✍️by Daniel Baecker et al. 🔗https://lnkd.in/g-n8HbnM

Metallothioneins are small Cys-rich proteins, that bind metal in defined clusters to obtain very stable structures. Many of them served as model proteins to establish NMR methodology. A lot of the structures at that time were determined in the lab of Kurt Wüthrich in Zurich. We have now used differential isotope labeling and heteronuclear NMR to investigate how metal ions are actually incorporated into these proteins, both into the apo protein but also into the metalated species. If you are interested please check out our paper: DOI:10.1002/pro.5186 One small remark: This study would not have been possible by cryo-EM (yeah...) and also not by crystallography (sorry, guys 😉 )

New Article: Expression optimization and characterization of a novel amylopullulanase from the thermophilic Cohnella sp. A01