ATCC’s Post

Global Experts Sound Alarm: Immediate Action Is Needed in Order To Prevent an H5N1 Pandemic. Amidst widespread H5N1 outbreaks, experts call for an immediate and structured response to influenza threats, highlighting the need for voluntary vaccination, improved vaccine stockpiles, and global cooperation to enhance pandemic preparedness and response - https://lnkd.in/gaWs5QeY

Excited to share our latest REAL-WORLD study on influenza vaccine effectiveness (IVE) during the 2023-24 flu season in China. Our study, conducted through the CHERRY study in Yinzhou, revealed that the flu vaccine offered substantial protection across all age groups, with an overall IVE of 49.4%. Notably, individuals with chronic comorbidities experienced a 44.4% reduction in infection risk. This season's early onset and high flu activity underscore the importance of timely vaccination in protecting public health. For more insights, check out the full article here: https://lnkd.in/gERPsF8e #Influenza #VaccineEffectiveness #PublicHealth #Research #Vaccination #Healthcare

Scientists used insights from prior studies on SARS-CoV-1 and MERS-CoV to quickly design the SARS-CoV-2 (COVID-19) vaccine. This “prototype pathogen” approach worked so efficiently that The National Institute of Allergy and Infectious Diseases (NIAID)) has called for a similar proactive effort to develop vaccines against viruses that are not currently—but very likely could become—of global concern. Albert Einstein College of Medicine’s Jon Lai, PhD, a 2021 Cure. XSeed Award Winner and his team are working to facilitate next generation #vaccine design to protect against Chikungunya, a mosquito-spread #virus that can cause a persistent form of #arthritis that currently has no treatment. Read more about Lai’s crucial #research. https://lnkd.in/emvFjPEc #wewillcure #innovation

Vivaldi is developing this game-changer universal flu vaccine: The current vaccines that we have for both influenza and coronavirus are good vaccines—but they're not great. They can reduce serious illness, hospitalizations, and deaths. But protection has a decidedly limited duration, and even if someone gets vaccinated, they could still get infected and transmit the virus. The best of all scenarios would be what we call a game-changer universal vaccine that creates a broad immune response that covers a wide range of flus or coronaviruses.” - Michael Osterholm, PhD, MPH https://lnkd.in/eB-YnWFe

The global vaccine landscape is evolving rapidly, with increasing demand for seasonal influenza vaccines and preparedness for pandemic outbreaks. Organisations like the World Health Organization, CEPI (Coalition for Epidemic Preparedness Innovations), and Gavi, the Vaccine Alliance, are working with governments to establish vaccine stockpiles for diseases with pandemic potential, such as influenza, COVID-19 variants, and other zoonotic threats. These stockpiles allow rapid deployment when outbreaks occur, minimising delays in vaccination campaigns. Will your supply chain deliver critical ingredients when under huge global demand? Send me a message to discuss how we can support future proofing your vaccine development. #Partnerships #Sustainability

The global vaccine landscape is evolving rapidly, with increasing demand for seasonal influenza vaccines and preparedness for pandemic outbreaks. Organisations like the World Health Organization, CEPI (Coalition for Epidemic Preparedness Innovations), and Gavi, the Vaccine Alliance, are working with governments to establish vaccine stockpiles for diseases with pandemic potential, such as influenza, COVID-19 variants, and other zoonotic threats. These stockpiles allow rapid deployment when outbreaks occur, minimising delays in vaccination campaigns. Will your supply chain deliver critical ingredients when under huge global demand? Send me a message to discuss how we can support future proofing your vaccine development. #Partnerships #Sustainability

Promising Development in Universal Influenza Vaccine Research A new study in Nature Communications brings hope for a universal influenza vaccine, potentially providing lifetime immunity with a single dose. Researchers from the University of Pittsburgh and Oregon Health and Science University tested a cytomegalovirus (CMV)-vectored vaccine on nonhuman primates. This innovative approach targets conserved internal influenza antigens, inducing a robust T cell immune response. In the study, vaccinated primates showed a 54.5% survival rate against a lethal H5N1 influenza challenge, unlike the unvaccinated group that did not survive. The key to this success was the presence of influenza-specific CD4+ T cells, offering broad and lasting protection. Dr. Jonah Sacha noted that this breakthrough could lead to a universal flu vaccine within 5 to 10 years, revolutionizing pandemic preparedness and infectious disease prevention. #UniversalVaccine #InfluenzaResearch #PandemicPreparedness Link to article-https://lnkd.in/ekgtWmZ3

📃Scientific paper: Indirect Protection from Vaccinating Children against Influenza A Virus Infection in Households Abstract: International audience; Influenza vaccination is an important intervention to prevent influenza virus infection. Our previous analysis suggested that indirect protection is limited in an influenza B epidemic in Hong Kong. We further analyzed six influenza A epidemics to determine such potential. We applied a statistical model to estimate household transmission dynamics in the 3 influenza A(H3N2) and 3 pandemic influenza A(H1N1) epidemics. Then, we estimated the reduction in infection risk among unvaccinated household members when all children in households are vaccinated, with different assumptions on vaccine efficacy (VE). In the optimal scenario that VE was 70%, the reduction to the total probability of infection was only marginal, with relative probabilities ranged from 0.91–0.94 when all children in households were vaccinated because community was by far the main source of infection during the six epidemics in our study. The proportion of cases attributed to household transmission was 10% (95% CrI: 7%, 13%). Individual influenza vaccination is important even when other household members are vaccinated, given the degree of indirect protection is small. Continued on ES/IODE ➡️ https://etcse.fr/wO2b ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Vaccines and the Diseases They Prevent Vaccines have been one of the most significant advancements in public health, providing a crucial lifeline against numerous infectious diseases. By stimulating the immune system to recognize and combat pathogens,… #Diseases #Vaccines >>> Read more

📃Scientific paper: Indirect Protection from Vaccinating Children against Influenza A Virus Infection in Households Abstract: International audience; Influenza vaccination is an important intervention to prevent influenza virus infection. Our previous analysis suggested that indirect protection is limited in an influenza B epidemic in Hong Kong. We further analyzed six influenza A epidemics to determine such potential. We applied a statistical model to estimate household transmission dynamics in the 3 influenza A(H3N2) and 3 pandemic influenza A(H1N1) epidemics. Then, we estimated the reduction in infection risk among unvaccinated household members when all children in households are vaccinated, with different assumptions on vaccine efficacy (VE). In the optimal scenario that VE was 70%, the reduction to the total probability of infection was only marginal, with relative probabilities ranged from 0.91–0.94 when all children in households were vaccinated because community was by far the main source of infection during the six epidemics in our study. The proportion of cases attributed to household transmission was 10% (95% CrI: 7%, 13%). Individual influenza vaccination is important even when other household members are vaccinated, given the degree of indirect protection is small. Continued on ES/IODE ➡️ https://etcse.fr/wO2b ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.