Atlas of Variant Effects Alliance’s Post

How have rapid advances in DNA synthesis techniques made it possible to engineer diverse genomic elements, pathways, and whole genomes, providing new insights into design and analysis of systems? Join our upcoming seminar with Dr. Jef Boeke, who will provide insight into this development of genomic engineering. During this seminar Dr. Boeke will discuss the synthetic yeast genome project, Sc2.0, which is well on its way with the 16 synthetic Saccharomyces cerevisiae chromosomes, and which has now been completed by a global team. Learn more: https://lnkd.in/esA8HVC2 #biomedicalengineering #genomicengineering #chromosomes #seminar 

🔬 At STEMCELL, we often highlight the significance of cell quality. A recent publication from the Barbaric lab at the University of Sheffield sheds light on the mechanism of how a common 1q duplication in hPSCs affects cell differentiation. 🧬 The study reveals that these abnormal hPSCs become hypersensitive to WNT signaling, thereby altering differentiation and maturation phenotypes. This is a great example of how genomic aberrations can affect downstream cell types, potentially biasing experimental interpretations. 📚 To read the full publication, click on the link: https://lnkd.in/g-bwkptZ #STEMCELL #CellQuality #GenomicAberrations #CellDifferentiation #Research #BarbaricLab #UniversityofSheffield

This Ganesh Chaturthi, we at Elango Genetics celebrate the remover of obstacles and the harbinger of wisdom. May Lord Ganesha inspire innovation, clarity, and success across all our endeavors in genomics research, molecular testing, and molecular diagnostics. Wishing our valued partners and clients a blessed and prosperous Ganesh Chaturthi! #GaneshChaturthi #ElangoGenetics #ElangoDiagnostics #ElangoVet #ElangoCrop #ElangoAquatix #GenomicsResearch #MolecularTesting #MolecularDiagnostics #DecodingTheDNA

Researchers identify therapies to limit COVID-19 risk in people with Down syndrome. Australian Institute for Bioengineering and Nanotechnology AIBN Senior Research Fellow Dr Mohammed Shaker and Phenomics Australia Scientific Director Professor Ernst Wolvetang, head of the In vitro Genome Engineering and Disease Modelling Service and organoid expert, worked with a team to develop a synthetic organoid that mirrors the brain of a person with Down syndrome, to explore why people born with the genetic condition are more vulnerable to the coronavirus. Read more here: https://lnkd.in/db2Pc3gY #NCRISImpact

#BGI-Research co-led the unveiling of a synthetic yeast model that decodes longevity secrets. Using engineered chromosome XIII, the scientists extended yeast lifespan and identified key aging-related genes through high-throughput screening. https://bit.ly/4fDIsVb

Researchers from UC San Diego have created an array of #nanopillars that can breach the #CellNucleus – the compartment that houses our #DNA – without damaging the #cell's outer membrane. This new “gateway into the nucleus” could open new possibilities in #GeneTherapy, where genetic material needs to be delivered directly into the nucleus, as well as drug delivery and other forms of #PrecisionMedicine. The nucleus is impenetrable by design. Its membrane is a highly fortified barrier that shields our genetic code, letting in only specific molecules through tightly controlled channels. https://lnkd.in/gYRmREBZ (Work funded by the United States Department of Defense, the National Science Foundation (NSF), and The National Institutes of Health) Zeinab Jahed Ali Sarikhani

🔬 𝗗𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝗶𝗻𝗴 𝘁𝗵𝗲 𝗜𝗻𝘀𝗶𝗱𝗲 𝗖𝗲𝗹𝗹’𝘀 𝗦𝘁𝗼𝗿𝘆 𝘄𝗶𝘁𝗵 𝗖𝗬𝗧𝗢𝗖𝗛𝗘𝗖𝗞 𝗦𝗣𝗔𝗰𝗵𝗶𝗽®! 🌟 Exciting insights from 𝗔𝟰𝗹𝗶𝘃𝗲𝗖𝗲𝗹𝗹 𝗕𝗹𝗼𝗴 #𝟲! Discover how #SPAchip technology is revolutionizing genetic screening by mapping genotypes to phenotypes with image-based profiling. This advanced method captures intricate spatial and morphological changes in cells, offering a comprehensive view of genetic modifications’ effects. #SPAchip provides real-time readouts of metabolic activity, measuring key elements like pH, ROS, and Ca2+, enhancing research efficiency and accuracy.⁣ ⁣ Learn more about how #SPAchip® is advancing cellular biology and therapeutic research! 🚀🔍⁣ ⁣ ▶ Read the full blog here: https://lnkd.in/dgdX48Xd #SPAchip #GeneticScreening #LiveCellImaging #MetabolicActivity

Aligning new innovation puts solutions for science in motion.

🚀 Empowering Cellular Research with SPAchip Technology! 🚀 At the cutting edge of cellular biology, SPAchip technology is revolutionizing how we understand cellular metabolism. Through the innovative CytoCHECK assay, SPAchip provides real-time, non-invasive insights into the dynamic processes within living cells. A4CELL leads the charge with SPAchip, empowering scientists worldwide to unlock cellular secrets and drive forward research and therapeutic advancements. 👉 Dive deeper into the power of SPAchip and CytoCHECK on our latest blog post: Deciphering the Inside Cell’s Story by CytoCHECK SPAchip #CellularBiology #SPAchip #CytoCHECK #A4CELL #Biotech #Innovation #Research #CellMetabolism #RealTimeData