Avicenna™’s Post

That is meeting the WHO recommendations. as a novel approach for the rapid detection of drug resistance to new anti-TB drugs.

📣 The World Health Organization (WHO) has just released new guidelines on the use of targeted next-generation sequencing (NGS) tests for the diagnosis of drug-resistant tuberculosis (TB) in their latest Consolidated guidelines on tuberculosis. 🧬 The recommendations provide a novel approach for the rapid detection of drug resistance to new anti-TB drugs using the latest technologies. This breakthrough can help to significantly improve the diagnosis of TB and the identification of drug-resistant strains. 🌍 With TB remaining a major public health threat globally, this new development is a step forward in the fight against the disease. The use of targeted NGS tests can help healthcare providers to quickly and accurately diagnose TB and provide patients with the appropriate treatment.

Aggressive TB screening and advanced molecular technology for early detection are crucial in combating tuberculosis effectively. Early identification through rigorous screening can prevent the spread of TB, particularly in high-risk communities. Advanced molecular techniques enhance the accuracy and speed of diagnosis, allowing for timely treatment initiation. This proactive approach not only reduces the transmission rates but also improves patient outcomes, ultimately contributing to better public health and a significant decrease in TB-related mortality and morbidity globally https://lnkd.in/gQX3ZQFy

Point of Care tests for TB can be transformative. It could be significantly lower cost per test (meaning health systems can rapidly scale testing volumes at same cost); and could reduce the diagnosis to treatment initiation gap (about 1 in 5 diagnose for TB but don’t link because it takes up to 2 days for results to return, and needs a second visit). Well done to all involved!

Let's save lives ! Fighting Tuberculosis has been a long running struggle for our and many other countries. I would say let's not measure it as a burden to the country but measure the challenge this disease brings to the patient and its family. I urge the scientific, clinical communities to use newer and better technologies to diagnose the infectious bacteria and its responsiveness to various available antibiotics. Patients not responding to anti-TB antibiotics are a special concern. Let's focus on solution/s that can give clear picture of the residing bacteria in the patient, treatment would eventually become effective. #savelivesfromTB

#ICYMI Bruker's webinar on reimaging the status quo for TB diagnostics Most people with drug-resistant tuberculosis (DR-TB) are never appropriately treated. This is primarily due to gaps in the diagnostic care cascade. This talk will summarise the landscape of drug-resistant tuberculosis in Africa and key challenges and opportunities for the molecular diagnosis of resistance to innovative new regimens. It will focus on the drug-resistant tuberculosis test pipeline and especially the promising LiquidArray® technology, including its application for XDR-TB detection and the underlying technology and implementation considerations required to maximize impact. Future research questions and lessons to be learnt from prior drug-resistant tuberculosis diagnostic technologies will be highlighted. 🧠 Understand the landscape of DR-TB and diagnostic gaps. 🏥 Understand the upcoming DR-TB pipeline and their strengths and limitations in the light of World Health Organization guidance. 💦 Understand the multiplexing LiquidArray® technology and its applications for XDR-TB detection. ⤴ Future research directions. You can view on demand here: https://lnkd.in/epSkpgcQ 📰 Follow Medical Device Developments to receive the latest medical device news daily and to subscribe to our weekly newsletter #MedicalDeviceDevelopments #bruker #tb #webinar

🔍 Exciting new insights into fungal infections! A recent case report highlights a tomographic presentation with a rare miliary pattern in a patient with pulmonary candidiasis. This publication emphasizes the importance of broadening diagnostic approaches beyond tuberculosis when encountering miliary patterns. Detecting Candida albicans in patients with compromised immunity is crucial for timely antifungal therapy, enhancing survival chances. Tragically, despite thorough investigation, a misdiagnosis led to poor outcomes for the patient featured in this study. For more, read the full article here: [PMID:39642286](https://lnkd.in/eS-QZfs6). Published on: 2024-12-06. 🚀 Contribute to groundbreaking research & treatments by supporting rare AI segments: [Donate to RareAI.org](https://lnkd.in/eJDi8V-M).

NGS for TB diagnosis will be a game changer in paucibacillary EPTB cases with an additional advantage for simultaneous detection of resistance to multiple drugs. TB sequencing portal will help in generating a database to identify emerging resistance and novel drug targets

ELISpot in tuberculosis diagnosis. Early and accurate diagnosis is critical in TB management. ELISpot is a popular method for TB diagnosis, with its high sensitivity and specificity. In our white paper, we examine the advantages of ELISpot and propose new antigens and biomarkers to enhance diagnostic accuracy. Get your white paper here: https://hubs.li/Q02qTdV20 #ELISpot #TBDiagnostic #TB

Welcome to read the new #issuecover from Interplays between host pattern-recognition receptors and pathogen ligands in immunogenic cell death by Xiaolong Shao et al. Nanjing Agricultural University Read all the papers in this Issue: https://lnkd.in/gU2GKfEJ #Coverstory:The strategic induction of cell death serves as a crucial #immune defense mechanism for the eradication of pathogen infections within #host #cells. Investigating the molecular mechanisms underlying immunogenic #cell #pathways has significantly enhanced our understanding of the host’s #immunity. This review provides a comprehensive overview of the immunogenic #cell death mechanisms triggered by pathogen infections, focusing on the critical role of pattern recognition receptors. In response to infections, #host #cells dictate a variety of #cell death pathways, including apoptosis, pyroptosis, necrosis, and lysosomal cell death, which are essential for amplifying #immune responses and controlling pathogen dissemination. Key components of these mechanisms are #host cellular receptors that recognize pathogen-associated ligands. These receptors activate downstream signaling cascades, leading to the expression of immunoregulatory genes and the production of antimicrobial cytokines and chemokines. Particularly, the inflammasome, a multi-protein complex, plays a pivotal role in these responses by processing pro-inflammatory cytokines and inducing pyroptotic #cell death. Pathogens, in turn, have evolved strategies to manipulate these cell death pathways, either by inhibiting them to facilitate their replication or by triggering them to evade host defenses. A deeper understanding of immunogenic cell death is crucial for developing novel immunotherapies, advancing infectious disease and cancer treatment, and revealing the complex interactions between dying cells and the #immunesystem. This review aims to provide systematic summarization as well as recent proceedings regarding the dynamic interplay between host immune mechanisms and pathogen strategies, highlighting the intricate co-evolution of microbial virulence and #host #immunity.