Bellen Chemistry Co., Ltd.’s Post

Do you need some R&D for a small molecule? We are proud of our leading custom complex chemical synthesis services from experts in our labs in the UK and Europe. From complex intermediates, novel NCEs and improved processes for your existing molecules, including identifying biocatalytic routes for all or part of the process. Then if you need it, we can take your project onwards for large-scale or GMP production at one of our high quality manufacturing sites. Oligosaccharide synthesis - Nucleosides, dinucleotides and analogues Heterocyclic chemistry - Fluorination, phosphorylation and sulphation chemistry - Novel enzyme substrates - Natural product synthesis - Impurities and metabolites - Protein conjugation, biotin and click linkers - Biocatalysis - Bioconjugation See more at https://lnkd.in/epdWSjtz #chemicalindustry #complexchemicals #biosynth

Samples #incubation 🧫🧫 Our commitment to excellence is reflected in the use of state-of-the-art #incubators and calibrated, validated temperature recording systems. At MCI, we implement precise protocols to verify the #sterility of #biological indicators, assessing dry heat, steam, and #Ethylene Oxide (#ETO) processes, in compliance with #ISO11138 and USP [1229.5] regulations. 👉 https://lnkd.in/enu9WXis Additionally, we offer #incubation services for #enviromental monitoring #plates, allowing the tracking of #microorganism presence in specific environments. We control and maintain precise process temperatures in our incubators, ensuring an environment conducive to the observation and #analysis of results. Our highly trained team and state-of-the-art facilities enable us to provide incubation services that meet the highest quality standards 👨🔬 🔬 #microbiological #microbiology #biologicalindicators #EthyleneOxide #USP1229 #medicaldevices #pharmaceuticalindustry #testing #samples #samplesincubation #laboratories Mauren Monge Mora Roberto Avila LuisMiguel Solano Luis Diego Gutiérrez Herrera Andres Villalobos Hector Coward Ugalde David Solórzano Arias José Carlos Barragán Fernández

Hey, DSP professionals! Still on a never-ending quest for the Holy Grail of chromatography resins? Well, the search might just be over. Meet WorkBeads™ 40 Butyl SH – your new best tool in the DSP toolbox. 🧪✨ With 𝗼𝘃𝗲𝗿 𝟯𝟬% 𝗵𝗶𝗴𝗵𝗲𝗿 𝗯𝗶𝗻𝗱𝗶𝗻𝗴 𝗰𝗮𝗽𝗮𝗰𝗶𝘁𝘆 than our closest competitor (looking at you, Capto Butyl ImpRes), this resin isn’t just playing in the big leagues; it’s changing the game. And if you thought it couldn’t get better, think again. WorkBeads™ 40 Butyl SH boasts the highest hydrophobicity in its class, making it a purification powerhouse for plasmids, proteins, peptides and oligonucleotides. 💧💪 Why settle for less when you can have the best? Our resin is designed for those who won’t compromise on resolution or purity. Whether you’re tackling recombinant proteins or diving deep into the world of plasmids and oligonucleotides, WorkBeads™ 40 Butyl SH is here to elevate your research and industrial scale purification processes. 🌟 🔬 𝗞𝗲𝘆 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀:: • 𝗨𝗻𝗺𝗮𝘁𝗰𝗵𝗲𝗱 𝗕𝗶𝗻𝗱𝗶𝗻𝗴 𝗖𝗮𝗽𝗮𝗰𝗶𝘁𝘆: Over 30% higher than the competition. Because more is more. • 𝗦𝘂𝗽𝗿𝗲𝗺𝗲 𝗛𝘆𝗱𝗿𝗼𝗽𝗵𝗼𝗯𝗶𝗰𝗶𝘁𝘆: Leading the pack with the ability to handle even the most challenging biomolecules. • 𝗩𝗲𝗿𝘀𝗮𝘁𝗶𝗹𝗶𝘁𝘆: Ideal for a wide range of applications, from academic research to biopharmaceutical production. • 𝗘𝗮𝘀𝗲 𝗼𝗳 𝗨𝘀𝗲: Comes in prepacked GoBio columns for convenience and reproducibility. Because who said cutting-edge science can’t be user-friendly? Ready to revolutionize your purification process and make your lab the envy of scientists everywhere? Let WorkBeads™ 40 Butyl SH take your research to the next level. 🚀🔬 https://lnkd.in/d9K-AKCn #Biotechnology #ProteinPurification #Chromatography #Innovation

https://lnkd.in/gyTvq3r8 The dearomatization of pyridines represents a well-established synthetic strategy for accessing piperidines, a valuable class of compounds in organic chemistry. Traditionally, dearomatization processes have involved hydrogenation or the addition of carbon-based nucleophiles to activated pyridiniums. However, a breakthrough has been achieved with the introduction of arenophile-mediated dearomatizations, which allow for the direct incorporation of heteroatom functionalities into pyridines without the need for prior substrate activation. This innovative approach leverages the arenophile platform in conjunction with olefin oxidation chemistry to facilitate the transformation. Through this method, dihydropyridine cis-diols and epoxides, previously challenging to access, can now be readily synthesized. These compounds represent important intermediates that can be further functionalized for the preparation of diverse piperidine derivatives. Overall, this advancement in dearomatization chemistry expands the toolbox of synthetic methods available to chemists, offering a straightforward route to heteroatom-functionalized piperidines and paving the way for the development of novel pharmaceuticals and functional materials.

Recently, Oleksandr Kozlov, Eliška Hančová, Eva Cífková, and Miroslav Lísa demonstrated the application of a commercial SFC instrument with electrospray ionization–mass spectrometry (MS) detection as a platform for the comprehensive analysis of metabolites with the full range of polarities. The SFC–MS analysis of polar metabolites were compared with widely established liquid chromatography MS analysis in metabolomics. Results showed different separation selectivity of metabolites using both methods. Explore more below. https://lnkd.in/g8rEFAGC ACS Publications, American Chemical Society, Eliška Hančová, Miroslav Lísa #lifesciences #naturalproducts #extraction #chromatography #sustainability #greenchemistry #smallmolecules #lipids #peptides #cannabinoids #technology #productionprocess #activepharmaceuticalingredients #pharma #agrochemical #food #perfume #terpenes #medicines #ecofriendly

#Nucleation_Lyo 🌎 In lyophilization (freeze-drying), the nucleation process can significantly impact the quality and consistency of the final product. Here’s a comparison between uncontrolled and controlled nucleation: Uncontrolled Nucleation 🔷 🔷 Temperature Range: Nucleation occurs over a wide range of temperatures, typically between -5°C and -15°C. Variability: This method results in a broad distribution of ice nucleation temperatures, leading to variability in ice crystal size and distribution2. Process Consistency: The lack of control can lead to inconsistencies in the drying process, affecting the final product’s quality and stability. Drying Time: Uncontrolled nucleation can result in longer primary drying times due to the irregular ice crystal formation. Controlled Nucleation 🔷 🔷 Temperature Control: Nucleation is induced at a specific temperature and time, leading to a more uniform ice crystal formation. Consistency: This method ensures a tighter distribution of nucleation temperatures, resulting in greater process consistency and repeatability. Product Quality: Controlled nucleation improves the homogeneity of the product properties across a batch, enhancing the overall quality and stability. Drying Efficiency: It can shorten the primary drying time by creating more uniform ice crystals, which facilitate better sublimation. Controlled nucleation is generally preferred in pharmaceutical and biotechnological applications due to its ability to produce more consistent and high-quality products. 🔴 🔵

In 2012, bicyclo[1.1.1]pentane (BCP) was demonstrated to mimic the para-substituted benzene ring in a biologically active compound. Since then, BCPs have been playing an important role in chemistry. This paper reports a general scalable reaction between alkyl iodides and propellane that provides bicyclo[1.1.1]pentane iodides in milligram, gram and even kilogram quantities.

Rational Design of Key #Enzymes to Efficiently Synthesize #Phycocyanobilin in #Escherichia coli:- •Phycocyanobilin (#PCB) is a natural #blue #tetrapyrrole #chromophore that is found in #phycocyanin and plays an essential role in #photosynthesis. •Due to PCB’s #antioxidation, #anti-inflammatory and #anti-cancer properties, it has been utilized in the food, pharmaceutical and cosmetic industries. •Currently, the extraction of #PCB from #Spirulina involves complex processes, which has led to increasing interest in the #biosynthesis of #PCB in #Escherichia coli. •However, the #PCB titer remains low because of the poor activity of key enzymes and the insufficient precursor supply. •Here, the synthesis of PCB was firstly improved by screening the optimal heme #oxygenase (HO) from #Thermosynechococcus elongatus #BP-1(HOT) and PCB: #ferredoxin oxidoreductase from #Synechocystis sp. #PCC6803 (#PcyAS). •In addition, based on a rational design and the #infrared fluorescence method for high-throughput screening, the mutants of #HOT (F29W/K166D) and #PcyAS (D220G/H74M) with significantly higher activities were obtained. •Furthermore, a DNA scaffold was applied in the assembly of #HOT and #PcyAS mutants to reduce the spatial barriers, and the #heme supply was enhanced via the moderate overexpression of #hemB and #hemH, resulting in the highest #PCB titer (184.20 mg/L) obtained in a 5 L fermenter. •The strategies applied in this study lay the foundation for the industrial production of #PCB and its #heme derivatives. #photosynthesis #phycocyanin #phycocyanobilin #enzymes

🚀𝐂𝐚𝐬𝐞 𝐒𝐭𝐮𝐝𝐲: 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐭𝐡𝐞 𝐈𝐦𝐩𝐚𝐜𝐭 𝐨𝐟 𝐅𝐥𝐨𝐰 𝐚𝐧𝐝 𝐌𝐢𝐱𝐢𝐧𝐠 𝐨𝐧 𝐬𝐜𝐚𝐥𝐞-𝐮𝐩  Request a FREE MixIT demo here: https://lnkd.in/fpBKdbq 𝐏𝐫𝐨𝐛𝐥𝐞𝐦 𝐒𝐭𝐚𝐭𝐞𝐦𝐞𝐧𝐭:  Particle Size Distribution (PSD) is often a critical quality attribute of the products. Replicating the lab scale PSD at production scale can be quite a daunting task. Quantifying the impact of flow and mixing is often the key to successful scale-up    PSD in suspension polymerization process is influenced by mixing behavior and the shear rate distribution in the vessel  Objective: Identify the ideal plant reactor to scale-up the suspension polymerization process 𝐇𝐨𝐰 𝐌𝐢𝐱𝐈𝐓 𝐡𝐞𝐥𝐩𝐞𝐝? The shear rate distribution of the lab scale and the available plant scale vessels was studied using MixIT  The comparison of the shear rate profiles showed that the hydrodynamic behavior of RX3013 vessel was similar to the lab scale reactor and hence it was more suitable for large scale production than RA1012  The test batch performed on RX3013 confirmed the MixIT results thereby saving $ 100,000 #mixit #mixingtechnology #chemical #chemicalindustry #pharmaindustry #pharmaceuticalmanufacturing #cfd #scaleup #processintelligence #processdevelopment #processindustry #productquality #computationalchemistry #mixingsimulation #simulationsoftware #fluiddynamics #rheology #foodandbeverage #foodandbeveragemanufacturing #foodandbeverageindustry #cosmeticsindustry #drugdevelopment #drugdesign #api #biopharmaceuticals

What's driving Medicinal Chemists to go with the goldilocks is the ability of Macrocyclics to provide functional diversity and stereochemical complexity within partially rigid structures, while offering new chemical spaces and novel intellectual property to play with. A growing numerous applications of macrocyclizations in lead optimization, to demonstrate that despite their large size, they tends to possess adequate cell permeability and bioavailability, which enables them to reach their intracellular targets after oral administration. An excellent review providing a detailed case study of the application of macrocyclization over the past 5 years, starting from the initial analysis of acyclic active compounds to optimization of the resulting macrocycles for improved efficacy and drug-like properties. https://lnkd.in/gPj55D23