[Life Sciences] Discover our new LEAP-2 Elisa kit! 👨🔬 As a member of the antimicrobial peptide family, LEAP-2, or Liver-Expressed Antimicrobial Peptide 2, plays a crucial role in the body's innate immune system, serving as a natural defense mechanism against a variety of microbial threats. Besides that, it is also involved in metabolic mechanisms as it is an antagonist of Ghreline. Understanding the function and regulation of LEAP-2 has implications for the development of new therapeutic strategies for infectious diseases, inflammatory conditions, and gastrointestinal disorders. In this new Application Note, discover the good performance of the new LEAP2 ELISA kit developed by Bertin Technologies. https://lnkd.in/d2cHn7HD Nabil Zerrari
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Pleased to share our paper investigating the role of synovial tissue (ST) myeloid dendritic cells (DCs) in health, active, and remission stages of rheumatoid arthritis (RA). This work is published on the cover of this months issue of Immunity! With single cell, spatial transcriptomics and DC-T cell cocultures, we identify functional features of distinct ST-DCs that provide insight into the roles of these cells in immune tolerance and disease.
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Check out our protocol for lipid mediator profiling of human macrophages during host-pathogen interaction, which we just published in STAR protocols. Here, we show several pathogen incubation techniques, such as Staphylococcus aureus but also Influenza A virus, which we established in the last years. @ Kerstin Günther well done! #lipidmediators #pathogens
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To Detect or To Prevent? If we detect a disease then we have to introduce preventive measures - as MRC Epidemiology Unit Nick Wareham states common Diabesity is VERY preventable - so why not simply prevent Diabesity from the start and save us all the bother of having to monitor? Take the path to diabetes/obesity/premature ageing through pursuing a lifestyle of wild blood glucose fluctuation and we'll have to do something about it at some point or other - so why not correct from the start?
Professor, Faculty of Medicine Director, UQ Centre for Extracellular Vesicle Nanomedicine Head, Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group NHMRC Investigator Fellow
Thanks to the Novo Nordisk Foundation for the invaluable opportunity to present our research on “Extracellular Vesicles Biomarkers in Ectopic Fat Accumulation – Liquid Biopsies for Early Detection and Real-Time Monitoring of Metabolic Disorders” at the prestigious 2025 Challenge Programme Symposium on Ectopic Fat & Cardiometabolic Diseases (CMD). Congratulations to all the speakers for their insightful presentations. The symposium fostered an incredible collaborative environment, sparking innovative discussions and potential partnerships that will undoubtedly advance our understanding and treatment of cardiometabolic diseases. Thank you for an inspiring and enriching experience! Aase Handberg Louise Dalgaard Danish Diabetes and Endocrine Academy
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🔬 Important Research Highlight 🔬 Discover pivotal insights into Staphylococcus aureus and its role in chronic airway infections. This study reveals that Staphylococcus aureus initiates a distinct immunometabolic response in the airway, driven by the metabolite itaconate. Key Findings: S. aureus triggers itaconate production through host mitochondrial stress. Itaconate disrupts S. aureus glycolysis, redirecting metabolism towards extracellular polysaccharide (EPS) synthesis and biofilm formation. Enhanced biofilm formation supports chronic infections by shielding bacteria from the immune system and antibiotics. These findings offer valuable perspectives for developing targeted treatments against chronic airway infections. 🖋️ Authors: Kira Tomlinson, Tania Wong Fok Lung, Felix Dach, Medini K. Annavajhala, PhD, Stanislaw Gabryszewski, MD, PhD, Ryan A Groves, Marija Drikic, Nancy J Francoeur, Shwetha Sridhar, Melissa L Smith, Sara Khanal, Clemente Britto, Robert Sebra, Ian Lewis, Anne-Catrin Uhlemann, Barbara C Kahl, Alice S Prince, Sebastián Riquelme 🔗 https://lnkd.in/dgGcjhWv #MedicalResearch #Immunometabolism #StaphylococcusAureus #BiofilmFormation #ChronicInfections #PhysicianInsights #MedicalPractice #DoctorsUpdate #CME
Acapedia CME | S. Aureus, Itaconate & Biofilm Formation
acapedia.com
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Gastrointestinal (GI) tract infections are among the main causes of gastroenteritis. Molecular diagnostics, such as real-time PCR, have shown higher sensitivity, specificity, and positive predictive value than culture, allowing more accurate detection of enteropathogenic bacteria to support effective patient outcomes. Get the facts with this educational infographic on GI infections. https://lnkd.in/g9SzEE5q
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Today on #NationalCOVID19Day, we’d like to highlight Nucleic Acid Amplification Tests (NAATs)—a vital tool in COVID-19 diagnostics. NAATs play a crucial role in detecting the genetic material of the virus, offering highly accurate results crucial for effective disease management and containment. 🦠 At iFyber, our team of dedicated scientists is committed to crafting innovative solutions to address the evolving challenges of infectious diseases like COVID-19. 😷 Explore iFyber's comprehensive assay development services, including Nucleic Acid-Based Molecular Assay Development, to see how we're innovating for a safer tomorrow: https://lnkd.in/g9dyibhB
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#Gelatin #StorageViruses #Virology #GelatinBasedFormulation Last week at The 71st Annual Meeting of the Japanese Society for Virology, our researcher Dr. Kadji gave an oral presentation titled “Storage of Enveloped and Nonenveloped Viruses in Gelatin-Based Formulation.” During the session, we received questions regarding the differences in effectiveness based on molecular weight, the varying effects between enveloped and nonenveloped viruses, as well as inquiries about recombinant gelatin. The discussions provided us with valuable insights, making it a truly fruitful experience for everyone involved. If you wish to continue the discussion, please feel free to reach out with your questions using the link below! https://lnkd.in/diUmQc4a
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Research Articles -Lymphoid System Development and Early Window of Immunological Susceptibility in Spotted Rose Snapper Lutjanus Guttatus. Available at SSRN: https://lnkd.in/eKk2DBtq or https://lnkd.in/eZZbKm2U -New-Onset Diabetes Mellitus after COVID-19: Combined Effects of SARS-CoV-2 Variants, Molecular Mimicry, and m6A RNA Methylation. COVID 2024, 4(4), 481-494; https://lnkd.in/eA6cc-wv -SARS-CoV-2 variants and associated cases during four epidemic waves in Sinaloa, Mexico. TIP 2023, 25:e474; https://lnkd.in/eM-Vryua -Predicted Secretome of the Monogenean Parasite Rhabdosynochus viridisi: Hypothetical Molecular Mechanisms for Host-Parasite Interactions. Parasitologia 2023, 3(1), 33-45; https://lnkd.in/eaC-6_7P
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🔬 New Findings on Lipoprotein(a) and Kidney Disease Risk 🔬 Recent research in the Journal of the American College of Cardiology highlights an important connection between high lipoprotein(a) levels and chronic kidney disease (CKD). This study involving over 108,000 participants shows that elevated lipoprotein(a) might play a direct role in kidney disease, in addition to its known cardiovascular risks. These insights could lead to new ways to assess and reduce CKD risk in the future. #HealthResearch #LipoproteinA #KidneyHealth #CardiovascularHealth #Genetics #MedicalResearch Check it out here: https://lnkd.in/eedRB2FT
High Lipoprotein(a) as a Cause of Kidney Disease: A Population-Based Mendelian Randomization Study
sciencedirect.com
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In need of products to study inflammatory diseases? Take a look at NLRP3, which is a pattern recognition receptor involved in detection of infectious organisms and stress signals, currently a promising therapeutic target to treat inflammatory diseases. Our catalog provides recombinant proteins, assay kits, and NLRP3 knockdown tools to assist your research! #NLRP3 #assay #cellline https://hubs.ly/Q02Cxb8r0
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