Biomedicines MDPI’s Post

#HighlyCitedPapers   📝 Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art — Luzzi, et al.   In this paper, the authors aimed at exploring the actual role of homocysteine in the pathogenesis of cognitive decline and to improve the diagnostic accuracy, differential diagnosis and the prognostic implications.   Full text is available 👇 https://lnkd.in/d84Ju5wX   #medicine #health #research #science

#EditorsChoice 📝 Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease — Leung, Foo and VanDongen. In this paper, the authors investigated how Arc regulates the transcription of #genes involved in #neuronal plasticity, excitability, and Alzheimer’s Disease. Full text is available 👇 https://lnkd.in/dzmJH4Vp #medicine #health #research #science

🔬 A recent pre-print has been published on the long-term effects of rapamycin. This study is the first of its kind, where participants received weekly doses of 5 or 10 mg over 48 weeks and placebo groups for comparison. 💊 The results indicate that rapamycin holds promise in counteracting various aspects of age-related decline and enhancing overall health. Notably, the effects were found to be sex-dependent, showing the most benefit in women. 🙋♀️ The authors highlight that this is one of the first studies to present evidence that rapamycin can positively influence human longevity markers. They also stress the importance of individualized dosing to optimize outcomes. 💡 This research positions rapamycin as a potentially pivotal player in the future of longevity medicine—offering not just extended lifespan but improved quality of life. 💪 It is important to note that all these results come from a pre-print, so they might contain errors. It has yet to be evaluated by the medical community. Read the full article.👇 https://lnkd.in/d4VHPhGK #Longevity #Science #Health #Rapamycin

#HighlyCitedPapers 📝 Human Trabecular Meshwork (HTM) Cells Treated with TGF-β2 or Dexamethasone Respond to Compression Stress in Different Manners — Watanabe et al. In this paper, the authors aimed to investigate the different effects of TGF-β2 and dexamethasone on two-dimensional and three-dimensional models of human trabecular meshwork cells upon mechanical compression stresses. Full text is available 👇 https://lnkd.in/esCuP3SU #medicine #health #research #science

#HighlyCitedPapers   📝 Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients — Bai, et al.   In this paper, the authors characterized the upper respiratory tract bacterial #microbiome at species level and their encoded pathways in patients with COVID-19 and correlated these to clinical outcomes.   Full text is available 👇 https://lnkd.in/ekzUzEP2   #medicine #health #research #science

#HighlyCitedPapers   📝 Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects — Bruno, et al.   In this paper, the authors aimed to review the clinical and molecular characteristics, current therapeutic options, and prognostic factors of elderly patients with #glioblastoma . Full text is available 👇 https://lnkd.in/dcjX6si5   #medicine #health #research #science

#HighlyCitedPapers   📝 Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders — Hofmann, et al.   In this paper, the authors aimed to summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.   Full text is available 👇 https://lnkd.in/dWekgDUr   #medicine #health #research #science

#HighlyCitedPapers   📝 Mechanisms of Synaptic Vesicle Exo- and Endocytosis — Sumiko Mochida.   In this paper, the authors aimed to provide a summary on the existing knowledge in synaptic vesicle #exocytosis and vesicle recovery by #endocytosis.   Full text is available 👇 https://lnkd.in/d6swiahy   #medicine #health #research #science

#HighlyCitedPapers   📝 Neuroimaging of Mouse Models of Alzheimer’s Disease — Amandine Jullienne, Michelle V. Trinh, and Andre Obenaus.   The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of Alzheimer’s Disease.   Full text is available 👇 https://lnkd.in/dv8Z_4yE   #medicine #health #research #science

Researchers at UCL recently invented carbon beads to reduce gut inflammation, but the results proved to be far more promising. The study found that the carbon beads could restore gut health and improve the function of the liver, kidney and brain too! Could this be an innovation in gut health? Learn more here: https://bit.ly/3w0FiJi #GutHealth #Science #UCL #GutHealthMatters